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Clozapine is an atypical antipsychotic which is generally used as a second line antipsychotic drug in clinical practice due to its side effects. It is known that Clozapine may induce hypersensitivity reaction, angioedema at the beginning of the treatment, late onset angioedema related to clozapine treatment is very rare in the literature. In this case report, we present a 19 years old man who was admitted to psychiatry with clozapine induced periorbital edema. He was receiving clozapine 200 mg per day for last two years when he applied to psychiatry. After reducing daily dose of clozapine to 150 mg, his periorbital edema regressed. It should be known that clozapine induced angioedema may develop not only at the beginning of the treatment but also during the treatment and may regress with dose reduction. Copyright © 2020 Indian Journal of Psychiatry.Background Depersonalization and derealization (DPDR) syndrome results from complex interwoven sensory motor experiences seen across psychiatric disorders. There is sparse literature from India on DPDR symptoms, their clinical and research utility. This study focuses frequency of coding the diagnosis of DPDR (ICD-10) and critical discussion about its clinical and research utility. UAMC-3203 nmr Methods A retrospective review of case files coded under ICD code F48.1 was carried out for 10 years and details were systematically analyzed for age, gender, duration, phenomenology, comorbid diagnosis, and pharmacological treatment. Results Fourteen patients received the diagnosis of DPDR. Mean duration of DPDR syndrome was 6 years (standard deviation [SD] = 2.2) while mean age of presentation to hospital was 24 years (SD = 2.5). Tactile imagery (50%), self-environmental integration (42%), and dream-reality integration (28%) were the major themes. Selective serotonin reuptake inhibitors were used as primary medication for 65% of patients. Conclusion Isolated DPDR syndrome has been diagnosed very rarely in recent past. Reasons may include ignoring the comorbid DPDR coding, inability to articulate DPDR symptoms, inadequate documentation and misinterpretation of symptoms or actually less prevalence of DPDR syndrome in India. Considering scanty literature on DPDR as a primary diagnosis, more studies are required to identify the actual prevalence and coding of DPDR in future. Copyright © 2020 Indian Journal of Psychiatry.Studies investigating the psychological aspects of cancer have gained importance in recent years. In these studies, the rates of depression and anxiety in cancer patients were examined, but the risk of suicide had not been examined. This study investigated the psychiatric diagnoses of depression, anxiety, and suicide risk in cancer patients. Eighty patients who met the inclusion criteria were administered the Beck Depression Inventory, State-Trait Anxiety Inventory, Structured Clinical Interview for DSM (SCID), and Suicide Probability Scale. The examination of the relationships across variables was assessed with Pearson's correlation analysis and stepwise multiple regression analysis. Due to SCID assessment, 45% of patients were found to have depression diagnosis, and 11.25% were found to have anxiety diagnosis. In the patients who had previous psychiatric diagnosis and treatment, total suicide probability scores demonstrated statistically significant differences. The frequency of depressive disorders and anxiety disorders in cancer patients is high. The studies investigating that suicide are rare, and in our findings, previous psychiatric diagnosis and treatment were risk factors. In the past studies, depression has been reported to be the most important factor in increasing the risk of suicide in cancer. Contrary to previous findings, according to the data obtained from this study, anxiety is the most important predictor of suicidal risk among all the determinants. Copyright © 2020 Indian Journal of Psychiatry.Context Schizophrenia has been associated with disorder of the dopamine system, which is downregulated by projections of the serotonin pathway. Dopamine and serotonin levels are regulated by a system of transporters and enzymes. In this research, dopamine transporter polymorphism (DAT-VNTR), serotonin transporter polymorphism (5-HTTLPR), monoamine oxidase A (MAOA-uVNTR), and catechol-o-methyl transferase (COMT Val158Met) polymorphisms have been investigated. Aims The aim of this study was to asses frequencies of these polymorphisms in the healthy control group and patients and to asses association with schizophrenia. Settings and Design Three hundred and fourteen healthy volunteers and 306 schizophrenia patients were included. Schizophrenia was diagnosed by Diagnostic and Statistical Manual-IV of the American Psychiatric Association, and mini international neuropsychiatric interview questionnaire was used for screening of healthy population. Materials and Methods Genotyping was performed using polymerase chaienia. Copyright © 2020 Indian Journal of Psychiatry.Background Every year the scientific sessions of Annual National Conference of Indian Psychiatric Society (ANCIPS) are marked by presentation of free papers, posters, and award paper sessions, which are usually meant for presentation of new research which is not yet published. Hence, it is expected that these papers will be published in near future so that the scientific literature is distributed and shared with wider audience. Aim This paper aims to evaluate the abstract to publication rate of papers presented during ANCIPS in the years 2012-2014. Materials and Methods For this study, all the free papers, posters, and award papers presented during the ANCIPS of 2012-2014 were listed, and electronic searches were carried out to search for published articles. In addition, one of the authors of papers not found in the electronic searches were contacted through E-mail. Results A total of 1081 papers were presented during the ANCIPS in the 3 year period under study. Of these, 64 were award papers, 622 were free papers, and 395 were posters. Majority (n = 807; 74.6%) of these could be categorized as research data-based presentations; this was followed by case reports/series (203; 18.8%), review of literature (n = 35; 3.3%), and others (n = 36; 3.3%). Overall, only 27% of the papers were published after at least 5 years of the presentation. Of all the award papers, 69.6% of papers were published, whereas only 26.8% of free oral papers and 22.5% of free posters were published. About half (45.6%) of the papers were published in national journals. In terms of indexing, among those which were published, 62.8% were published in Medline-indexed (PubMed-listed) Journals with a mean impact factor of 1. Conclusion The present study shows that only 27% of the abstracts presented during the ANCIPS are ultimately published as full text articles in the next 5 years. Copyright © 2020 Indian Journal of Psychiatry.
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