Notes

AOAR: An automated ocular items removal means for multi-channel EEG information depending on NMF and also EMD.
Perinatal exposure to maternal obesity results in predisposition of offspring to develop obesity later in life. Increased weight gain in offspring exposed to maternal obesity is usually associated with hyperphagia, implicating altered central regulation of food intake as a cause. We aimed to define how maternal obesity impacts early development of the hypothalamus to program lasting dysfunction in feeding regulatory pathways.

Mice offspring of diet-induced obese mothers were compared to the offspring of lean control mothers. We analysed gene expression in the fetal hypothalamus, alongside neurosphere assays to investigate the effects of maternal obesity on neural progenitor cell proliferation invitro. Western blotting was used to investigate the insulin signalling pathway in the fetal hypothalamus. Characterisation of cell type and neuropeptide profile in adulthood was linked with analyses of feeding behaviour.

There was a reduction in the expression of proliferative genes in the fetal hypothalamus of oal hypothalamic insulin resistance in an obese pregnancy and suggests a mechanism by which maternal obesity causes permanent changes to hypothalamic structure and function.
These findings show that maternal obesity alters the molecular signature in the developing hypothalamus, which is associated with disrupted growth and development of hypothalamic precursor cells and defective feeding regulation in adulthood. This is the first report of fetal hypothalamic insulin resistance in an obese pregnancy and suggests a mechanism by which maternal obesity causes permanent changes to hypothalamic structure and function.
Canonical Wnt/β-catenin signaling is a well-studied endogenous regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and inhibiting adipogenesis. However, emerging genetic evidence in humans links a number of Wnt pathway members to body fat distribution, obesity, and metabolic dysfunction, suggesting that this pathway also functions in adipocytes. Recent studies in mice have uncovered compelling evidence that the Wnt signaling pathway plays important roles in adipocyte metabolism, particularly under obesogenic conditions. However, complexities in Wnt signaling and differences in experimental models and approaches have thus far limited our understanding of its specific roles in this context.

To investigate roles of the canonical Wnt pathway in the regulation of adipocyte metabolism, we generated adipocyte-specific β-catenin (β-cat) knockout mouse and cultured cell models. We used RNA sequencing, ChIP sequencing, and molecular approaches to assess expression of Wnt targets and lipogaken together, our studies demonstrate that Wnt signaling in adipocytes is required for lipogenic gene expression, de novo lipogenesis, and lipid desaturation. In addition, adipose tissues rigorously defend Wnt signaling homeostasis under standard nutritional conditions, such that stromal-vascular cells sense and compensate for adipocyte-specific loss. These findings underscore the critical importance of this pathway in adipocyte lipid metabolism and adipose tissue function.
Taken together, our studies demonstrate that Wnt signaling in adipocytes is required for lipogenic gene expression, de novo lipogenesis, and lipid desaturation. In addition, adipose tissues rigorously defend Wnt signaling homeostasis under standard nutritional conditions, such that stromal-vascular cells sense and compensate for adipocyte-specific loss. These findings underscore the critical importance of this pathway in adipocyte lipid metabolism and adipose tissue function.Bodily gestures play an important role in the communication of expressive intentions between humans. Music ensemble performance, as an outstanding example of nonverbal human communication, offers an exemplary context to study and understand the gestural control and communication of these expressive intentions. An important mechanism in music ensemble performance is the anticipation and control of interpersonal timing. When performing, musicians are involved in a complex system of mutual adaptation which is not completely understood so far. In this study, we investigated the role of performers' gestures in the mediation process of interpersonal timing in a dyad performance. Therefore, we designed an experiment in which we controlled for the use of hand and arm movements in a musical task, in which dyads were asked to synchronously tap out a melody. Next to their comfortable/natural way of tapping, we instructed participants to either perform pronounced expressive hand and arm gestures in between successive taps, or to restrict from any overt body movement. In addition, we looked at effects of visual contact (yes/no) and tempo (slow 50 beats per minute; fast 100 beats per minute). The results show that performers' gestures improve interpersonal musical timing, in terms of the consistency and accuracy of onset asynchronies, and of the variability of produced inter-onset intervals. Interestingly, we found that the use of expressive gestures, in regard to comfortable/natural movements, add to these positive timing effects, but only when there is visual contact and at the slow tempo. check details In addition, we found that the type of gestures employed by musicians may modulate leader-follower dynamics. Together, these findings are explained by human anticipation mechanisms facilitated by gesturing, shedding new light on the principles underlying human communication of expressive intentions, through music.The goal of new adaptive technologies is to allow humans to interact with technical devices, such as robots, in natural ways akin to human interaction. Essential for achieving this goal, is the understanding of the factors that support natural interaction. Here, we examined whether human motor control is linked to the visual appearance of the interaction partner. Motor control theories consider kinematic-related information but not visual appearance as important for the control of motor movements (Flash & Hogan, 1985; Harris & Wolpert, 1998; Viviani & Terzuolo, 1982). We investigated the sensitivity of motor control to visual appearance during the execution of a social interaction, i.e. a high-five. In a novel mixed reality setup participants executed a high-five with a three-dimensional life-size human- or a robot-looking avatar. Our results demonstrate that movement trajectories and adjustments to perturbations depended on the visual appearance of the avatar despite both avatars carrying out identical movements.
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