Notes

Probing the actual neurological poisoning regarding pyrene to the earthworm Eisenia fetida as well as the toxicity walkways of oxidative destruction: A systematic study at the pet along with molecular ranges.
We show that deep learning attains super-resolution with challenging contrast-agent densities, both in-silico as well as in-vivo. Deep-ULM is suitable for real-time applications, resolving about 70 high-resolution patches ( 128×128 pixels) per second on a standard PC. Exploiting GPU computation, this number increases to 1250 patches per second.People with diabetes are at risk of developing an eye disease called diabetic retinopathy (DR). This disease occurs when high blood glucose levels cause damage to blood vessels in the retina. Computer-aided DR diagnosis has become a promising tool for the early detection and severity grading of DR, due to the great success of deep learning. However, most current DR diagnosis systems do not achieve satisfactory performance or interpretability for ophthalmologists, due to the lack of training data with consistent and fine-grained annotations. To address this problem, we construct a large fine-grained annotated DR dataset containing 2,842 images (FGADR). Specifically, this dataset has 1,842 images with pixel-level DR-related lesion annotations, and 1,000 images with image-level labels graded by six board-certified ophthalmologists with intra-rater consistency. The proposed dataset will enable extensive studies on DR diagnosis. Further, we establish three benchmark tasks for evaluation 1. DR lesion segmentation; 2. DR grading by joint classification and segmentation; 3. Transfer learning for ocular multi-disease identification. Moreover, a novel inductive transfer learning method is introduced for the third task. Extensive experiments using different state-of-the-art methods are conducted on our FGADR dataset, which can serve as baselines for future research. Our dataset will be released in https//csyizhou.github.io/FGADR/.Short-term monitoring of lesion changes has been a widely accepted clinical guideline for melanoma screening. When there is a significant change of a melanocytic lesion at three months, the lesion will be excised to exclude melanoma. However, the decision on change or no-change heavily depends on the experience and bias of individual clinicians, which is subjective. For the first time, a novel deep learning based method is developed in this paper for automatically detecting short-term lesion changes in melanoma screening. The lesion change detection is formulated as a task measuring the similarity between two dermoscopy images taken for a lesion in a short time-frame, and a novel Siamese structure based deep network is proposed to produce the decision changed (i.e. not similar) or unchanged (i.e. similar enough). Under the Siamese framework, a novel structure, namely Tensorial Regression Process, is proposed to extract the global features of lesion images, in addition to deep convolutional features. In order to mimic the decision-making process of clinicians who often focus more on regions with specific patterns when comparing a pair of lesion images, a segmentation loss (SegLoss) is further devised and incorporated into the proposed network as a regularization term. To evaluate the proposed method, an in-house dataset with 1,000 pairs of lesion images taken in a short time-frame at a clinical melanoma centre was established. Experimental results on this first-of-a-kind large dataset indicate that the proposed model is promising in detecting the short-term lesion change for objective melanoma screening.Although multi-view learning has made significant progress over the past few decades, it is still challenging due to the difficulty in modeling complex correlations among different views, especially under the context of view missing. To address the challenge, we propose a novel framework termed Cross Partial Multi-View Networks (CPM-Nets), which aims to fully and flexibly take advantage of multiple partial views. We first provide a formal definition of completeness and versatility for multi-view representation and then theoretically prove the versatility of the learned latent representations. For completeness, the task of learning latent multi-view representation is specifically translated to a degradation process by mimicking data transmission, such that the optimal tradeoff between consistency and complementarity across different views can be achieved. Equipped with adversarial strategy, our model stably imputes missing views, encoding information from all views for each sample to be encoded into latent representation to further enhance the completeness. Furthermore, a nonparametric classification loss is introduced to produce structured representations and prevent overfitting, which endows the algorithm with promising generalization under view-missing cases. Extensive experimental results validate the effectiveness of our algorithm over existing state of the arts for classification, representation learning and data imputation.
One difficulty in turning algorithm design for inertial sensors is detecting two discrete turns in the same direction, close in time. A second difficulty is under-estimation of turn angle due to short-duration hesitations by people with neurological disorders. We aim to validate and determine the generalizability of a I. Caspofungin Fungal inhibitor Discrete Turn Algorithm for variable and sequential turns close in time and II Merged Turn Algorithm for a single turn angle in the presence of hesitations.

We validated the Discrete Turn Algorithm with motion capture in healthy controls (HC, n=10) performing a spectrum of turn angles. Subsequently, the generalizability of the Discrete Turn Algorithm and associated, Merged Turn Algorithm were tested in people with Parkinsons disease (PD, n =124), spinocerebellar ataxia (SCA, n=51), and HC (n=125).

The Discrete Turn Algorithm shows improved agreement with optical motion capture and with known turn angles, compared to our previous algorithm by El-Gohary et al. The Merged Turn algorithm that merges consecutive turns in the same direction with short hesitations resulted in turn angle estimates closer to a fixed 180-degree turn angle in the PD, SCA, and HC subjects compared to our previous turn algorithm. Additional metrics were proposed to capture turn hesitations in PD and SCA.

The Discrete Turn Algorithm may be particularly useful to characterize turns when the turn angle is unknown, i.e. during free-living conditions. The Merged Turn algorithm is recommended for clinical tasks in which the single-turn angle is known, especially for patients who hesitate while turning.
The Discrete Turn Algorithm may be particularly useful to characterize turns when the turn angle is unknown, i.e. during free-living conditions. The Merged Turn algorithm is recommended for clinical tasks in which the single-turn angle is known, especially for patients who hesitate while turning.
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