Notes

Anti-enterococcal and anti-oxidative prospective of a thermophilic cyanobacterium, Leptolyngbya sp. HNBGU 003.
tibialis anterior zu M. gastrocnemius medialis und lateralis (T/G-ratio) und des M. vastus medialis und lateralis zum M. bizeps femoris und M. semitendinosus (V/I-ratio) zum Zeitpunkt vor (–150 bis 0 ms pre), während (0–30 ms post) und von 30 ms bis 150 ms post der ersten Bodenkontaktaufnahme mit Hilfe elektromyografischer Messungen darzustellen. Die statistische Prüfung erfolgte mittels des nonparametrischen L-Puri-Sen-Verfahrens. Das Signifikanzniveau wurde auf p  0,05). SCHLUSSFOLGERUNG  Es kann davon ausgegangen werden, dass Kinesiotape – KT und IQ-Tape – IQ keine relevanten detektierbaren Änderungen der Muskelaktivierung bei gesunden Personen hervorrufen. TJ-M2010-5 cost Zukünftige Studien sollten Patienten einschließen, die eine pathologisch veränderte neuromuskuläre Kontrolle aufweisen.in English, German HINTERGRUND  Die Wettkampfleistung während Berg-Ultramarathons mit kurzen Wettkampflängen bis zu 75 km steht in Zusammenhang mit den im Labor bestimmten Leistungsparametern (z. B. mit der maximalen Sauerstoffaufnahme). Es ist nicht bekannt, ob längere Wettkämpfe eine ähnliche Beziehung aufweisen. FRAGESTELLUNG  Die Studie zielte darauf ab, den Zusammenhang zwischen laborbasierten Leistungsparametern und den Laufzeiten eines kurzen (68 km) und eines langen (121 km) Berg-Ultramarathons zu untersuchen. MATERIAL UND METHODEN  11 männliche Teilnehmer der kurzen und 7 männliche Teilnehmer der langen Laufstrecke wurden untersucht. Alle Teilnehmer absolvierten in den 2 Wochen vor dem Wettkampf einen Ausbelastungstest am Laufband. Während des Marathons wurden die Herzfrequenz aufgezeichnet und die Endzeiten registriert. ERGEBNISSE  Die maximale Sauerstoffaufnahme und die Sauerstoffaufnahme an den Belastungsschwellen 1 und 2 korrelierten mit der Laufzeit während des kurzen Wettkampfs (~12h; r = –0,764 bis r = –0,782; p  0,05). SCHLUSSFOLGERUNG  Diese Studie zeigt, dass die im Labor bestimmten Leistungsparameter mit der Wettkampfzeit bei Berg-Ultramarathon-Events mit einer Dauer von ~12 h in Zusammenhang stehen. Bei längeren Laufzeiten, d. h. ~28 h, scheinen andere Faktoren, die in der vorliegenden Untersuchung nicht bestimmt wurden, wie zum Beispiel Erfahrung, Rennstrategie, Umgang mit Schmerzen und Ermüdungsresistenz, für die Leistung ausschlaggebend zu sein.BACKGROUND  High morbidity and mortality are frequently reported in intensive care patients suffering from severe sepsis with systemic inflammation. With the development of severe respiratory failure, extracorporeal membrane oxygenation (ECMO) is often required. In this study, cytokine adsorption therapy in combination with ECMO is applied in patients with acute respiratory distress syndrome (ARDS) due to severe pneumogenic sepsis. The efficacy of this therapy is evaluated compared with a historical cohort without hemoadsorption therapy. METHODS  Between January and May 2018, combined high-flow venovenous ECMO and CytoSorb therapy (CytoSorb filter connected to ECMO circuit) was applied in patients (n = 13) with pneumogenic sepsis and ARDS. These patients were prospectively included (CytoSorb group). Data from patients (n = 7) with pneumogenic sepsis and ECMO therapy were retrospectively analyzed (control group). RESULTS  All patients survived in the CytoSorb group, where the 30-day mortality rate reached 57% in the control group. After CytoSorb therapy, we instantly observed a significant reduction in procalcitonin (PCT) and C-reactive protein (CRP) levels compared with the control group. Within 48 hours, the initial high doses of catecholamine could be weaned off only in the CytoSorb group. CONCLUSIONS  Our results indicate that CytoSorb in combination with ECMO is an effective therapy to prevent escalation of sepsis with rapid weaning off high-dose catecholamine infusions and quick reduction in PCT and CRP levels. Optimal timing of immunomodulatory therapy and impact on ECMO-related inflammation still need to be furtherly investigated. Georg Thieme Verlag KG Stuttgart · New York.BACKGROUND  Numerous studies have documented the safety of alternatives access (AA) transcatheter aortic valve replacement (TAVR) for patients who are not candidates for transfemoral or surgical approach. There is a scarcity of studies relating use of AA TAVR in nonagenarian patients, a high-risk, frail group. Our study sought to investigate the clinical outcomes of nonagenarians who underwent AA TAVR for aortic stenosis, with comparison of nonagenarians age ≥90 years with patients age less then 90 years. METHODS  A cohort study of 171 consecutive patients undergoing AA TAVR (transapical [TA, n = 101, 59%], transaxillary [TAX, n = 56, 33%], transaortic [TAO, n = 11, 6%], and transcarotid [TC, n = 3, 2%]) from 2012 to 2019 was analyzed. Baseline, operative, and postoperative characteristics, as well as actuarial survival outcomes, were compared. RESULTS  AA TAVR patients had decreased aortic valve gradients with no difference detected in nonagenarians and younger patients. Operative mortality was 8% (n = 14; nine TA, three TAO, and two TAX). Compared to younger patients, significantly more nonagenarians were recorded to have new onset atrial fibrillation (7 vs. 5%, p  less then  0.01*). No significant difference in mortality or postoperative complications, such as stroke, pacemaker requirements, was detected. Actuarial survival at 1 and 5 years was 86 versus 87% (nonagenarians vs younger patients) and 36 versus 22%, respectively, with log-rank = 0.97. CONCLUSION  AA TAVR in nonagenarian patients who are not candidates for transfemoral approach can be efficaciously performed with comparable clinical outcomes to younger patients, age less then 90 years. Furthermore, some access sites should be avoided when possible; notably TA was associated with increased mortality, stroke, and new onset atrial fibrillation. Georg Thieme Verlag KG Stuttgart · New York.BACKGROUND  This meta-analysis was conducted to evaluate the impact of perioperative use of beta-blocker (BB) on postoperative atrial fibrillation (POAF) after cardiac surgery other than isolated coronary artery bypass grafting (CABG). METHODS  Five online databases were searched. Studies were included if they (1) enrolled patients who underwent cardiac surgery other than isolated CABG and (2) demonstrated the impact of perioperative use of BB on POAF based on the randomized controlled trial or adjusted analysis. The primary outcome was the occurrence rates of POAF after cardiac surgery. A meta-regression and subgroup analysis were performed according to the proportion of patients with cardiac surgery other than isolated CABG and the timing of BB use, respectively. RESULTS  Thirteen articles (5 randomized and 8 nonrandomized studies n = 25,496) were selected. Proportion of enrolled patients undergoing cardiac surgery other than isolated CABG ranged from 7 to 100%. The BBs were used in preoperative, postoperative, and both periods in 5, 5, and 3 studies, respectively.
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