Notes

Sulfated poly-amido-saccharides (sulPASs) are generally anticoagulants within vitro and in vivo.
The same brain networks related to WM were compromised in schizophrenia, major depressive disorder and bipolar disorder.

Our findings support the suggestion of commonal functional abnormalities across schizophrenia and mood disorders related to WM.
Our findings support the suggestion of commonal functional abnormalities across schizophrenia and mood disorders related to WM.Overuse of antibiotics is accelerating the spread of resistance risk in the environment. In drinking water supply systems, the effect of antibiotics on the resistance of biofilm is unclear, and there have been few studies in disinfectant-containing systems. Here, we designed a series of drinking water supply reactors to investigate the effects of antibiotics on biofilm and bacteria in the water. At low concentrations, antibiotics could promote the growth of bacteria in biofilm; among the tested antibiotics (tetracycline, sulfadiazine and chloramphenicol), tetracycline had the strongest ability to promote this. And the antibiotic resistant bacteria (ARB) could inhibit the growth of bacteria in drinking water. Results have shown that antibiotics enhanced the bacterial chlorine resistance in the effluent, but reduced that in the biofilm. Furthermore, metagenomic analysis showed that antibiotics reduced the richness of biofilm communities. The dominant phyla in the biofilm were Proteobacteria, Planctomycetes, and Firmicutes. In tetracycline-treated biofilm, the dominant phylum was Planctomycetes. In sulfadiazine- and chloramphenicol-treated groups, bacteria with complex cell structures preferentially accumulated. The dominant class in biofilm in the ARB-added group was Gammaproteobacteria. The abundance of antibiotic resistant genes (ARGs) was correlated with biofilm community structure. This study shows that antibiotics make the biofilm community structure of drinking water more resistant to chlorine. ARGs may be selective for certain bacteria in the process, and there may ultimately be enhanced chlorine and antibiotic resistance of effluent bacteria in drinking water.Soil and groundwater contamination with potentially toxic elements (PTEs) including cadmium (Cd) and copper (Cu) has become a serious problem for ecosystem functioning. Silicon (Si) may precipitate these metals as silicates, and may also form, at undersaturation of silicates, 'Si-contaminant compounds', i.e. particles of polymerized silica with PTEs incorporated or adsorbed by inner-sphere complexes. While the formation of these compounds in aqueous solution has been proven, their formation in soil remains unclear yet. Therefore, we conducted column experiments with a topsoil horizon artificially contaminated with Cd or Cu solutions (10 mM) in the presence (10 mM) and absence of monomeric Si, and monitored the elemental composition of the eluates during 12 irrigation steps with artificial rainwater by microwave-plasma atomic emission spectrometry, the size and charge of the particles eluted by dynamic light scattering and phase analysis light scattering, and determined the spatial distribution of total and exchangeable Cd and Cu in soil after the experiments. When Si was previously applied to soil, significantly larger particles (up to > 200 nm) in the eluates indicated Si polymerization and formation of Si-contaminant compounds. However, Cd and Cu concentrations were very low ( less then 0.4 μM), pointing to efficient retardation in soil. In any variant, the particles formed were slightly negatively charged (-11 mV). The molar metalSi ratios in the eluates and significant correlations between the amounts of Si and metals in soil extracted by NH4NO3 pointed to the formation of Si-contaminant compounds, too. More Cu than Cd was retained in soil, and significantly more in the presence of Si, but less Cu than Cd was in exchangeable form. While particularly Cu formed Si-contaminant compounds, which reduced the concentration of Cu ions, the Si-contaminant-compound particles in the eluates remained very small, thus potentially susceptible to particulate export from soil into the groundwater.Plastic mulching and straw incorporation are common agricultural practices in China. Plastic mulching is suspected to be a significant source of microplastics in terrestrial environments. Straw incorporation has many effects on the storage of soil organic carbon (SOC) and greenhouse gas emissions, but these effects have not been studied in the presence of microplastic pollution. In this study, 365-day soil incubation experiments were conducted to assess the effects of maize straw and polyethylene microplastics on SOC fractions and carbon dioxide (CO2) and nitrous oxide (N2O) emissions in two different soils (fluvo-aquic and latosol). Against the background of straw incorporation, microplastics reduced the mineralization and decomposition of SOC, resulting in a microbially available SOC content decrease by 18.9%. In addition, microplastics were carbon-rich, but relatively stable and difficult to be used by microorganisms, thus increasing the mineral-associated SOC content by 52.5%. This indicated that microplastics had adverse effects on microbially available SOC and positive effects on mineral-associated SOC. Microplastics also decreased coarse particulate SOC (>250 μm), and increased non-aggregated silt and clay aggregated SOC ( less then 53 μm). Furthermore, microplastics changed microbial community compositions, thereby reducing the CO2 and N2O emissions of straw incorporation by 26.5%-33.9% and 35.4%-39.7%, respectively. These results showed that microplastics partially offset the increase of CO2 and N2O emissions induced by straw incorporation. Additionally, the inhibitory effect of microplastics on CO2 emissions in fluvo-aquic soil was lower than that in latosol soil, whereas the inhibitory effect on N2O emissions had the opposite trend.Maricultured organisms are chronically exposed to water containing antibiotics but the bioaccumulative behavior of antibiotics in exposed organisms at different growth stages has received little attention. Here, we investigated the concentrations and tissue-specific bioaccumulation characteristics of 19 antibiotics during three growth stages (youth stage, growth stage, and adult stage) of various organisms (Scophthalmus maximus, Penaeus vannamei, Penaeus japonicus, and Apostichopus japonicus) cultivated in typical marine aquaculture regions, and explored the factors that could affect the bioaccumulation of antibiotics. Tetracyclines (TCs) and fluoroquinolones (FQs) were the dominant antibiotics in all organisms, and the total concentrations of the target antibiotics in fish (S. ML162 order maximus) were significantly higher than those in shrimp (P. vannamei and P. japonicus) and sea cucumber (A. japonicus) (p less then 0.01). The bioaccumulation capacity of a class of statistically significant antibiotics in most samples was strongest during the youth stage and weakest during the adult stage.
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