Notes

Pulse-gated noncontrast thoracic permanent magnet resonance angiography for severe aortic dissection together with temporary ischemic invasion: In a situation statement.
Diagnosing cutaneous cytomegalovirus (CMV) is difficult due to its rarity and diverse manifestations, and early recognition is crucial as it may indicate disseminated disease and a poor prognosis. We examined a 71-year-old Taiwanese male presenting with a 1-week history of progressive, painful papulopustules associated with superficial ulcers and thick yellowish crusts on the scalp. He had been diagnosed with stage IVb lung adenocarcinoma 6 weeks earlier, and the epidermal growth factor receptor inhibitor (EGFRI) erlotinib and radiotherapy had been started to treat brain metastases 1 month before he came to our clinic. Histopathological examination of a scalp lesion and ELISA and PCR testing of blood samples were indicative of disseminated CMV infection. Unfortunately, the patient passed away the day after his scalp biopsy, before the investigations confirmed the infection. We would like to highlight the importance of remaining vigilant for cutaneous CMV in end-stage cancer patients receiving tyrosine kinase inhibitors (TKIs) and recognizing how this potentially life-threatening viral infection can masquerade as a possible side effect of erlotinib.The use of retaining glycoside hydrolases as synthetic tools for glycochemistry is highly topical and the focus of considerable research. However, due to the incomplete identification of the molecular determinants of the transglycosylation/hydrolysis partition (t/h), rational engineering of retaining glycoside hydrolases to create transglycosylases remains challenging. Therefore, to understand better the factors that underpin transglycosylation in a GH51 retaining α-l-arabinofuranosidase from Thermobacillus xylanilyticus, the investigation of this enzyme's active site was pursued. Specifically, the properties of two mutants, F26L and L352M, located in the vicinity of the active site are described, using kinetic and 3D structural analyses and molecular dynamics simulations. The results reveal that the presence of L352M in the context of a triple mutant (also containing R69H and N216W) generates changes both in the donor and acceptor subsites, the latter being the result of a domino-like effect. Overall, the mutant R69H-N216W-L352M displays excellent transglycosylation activity (70 % yield, 78 % transfer rate and reduced secondary hydrolysis of the product). In the course of this study, the central role played by the conserved R69 residue was also reaffirmed. The mutation R69H affects both the catalytic nucleophile and the acid/base, including their flexibility, and has a determinant effect on the t/h partition. Finally, the results reveal that increased loop flexibility in the acceptor subsites creates new interactions with the acceptor, in particular with a hydrophobic binding platform composed of N216W, W248 and W302.Optically-pumped magnetometers (OPMs) offer the potential for a step change in magnetoencephalography (MEG) enabling wearable systems that provide improved data quality, accommodate any subject group, allow data capture during movement and potentially reduce cost. However, OPM-MEG is a nascent technology and, to realise its potential, it must be shown to facilitate key neuroscientific measurements, such as the characterisation of brain networks. Networks, and the connectivities that underlie them, have become a core area of neuroscientific investigation, and their importance is underscored by many demonstrations of their disruption in brain disorders. Consequently, a demonstration of network measurements using OPM-MEG would be a significant step forward. Here, we aimed to show that a wearable 50-channel OPM-MEG system enables characterisation of the electrophysiological connectome. To this end, we measured connectivity in the resting state and during a visuo-motor task, using both OPM-MEG and a state-of-the-art 275-channel cryogenic MEG device. Our results show that resting-state connectome matrices from OPM and cryogenic systems exhibit a high degree of similarity, with correlation values >70%. In addition, in task data, similar differences in connectivity between individuals (scanned multiple times) were observed in cryogenic and OPM-MEG data, again demonstrating the fidelity of the OPM-MEG device. This is the first demonstration of network connectivity measured using OPM-MEG, and results add weight to the argument that OPMs will ultimately supersede cryogenic sensors for MEG measurement.The ability to adopt the perspectives of others is fundamental to effective communication in social interactions. However, the neural correlates of allocentric thinking in communicative signaling remain unclear. We adapted a novel signaling task in which the signaler was given the target word and must choose a one-word signal to help the receiver guess the target. Behavioral results suggest that speakers can use allocentric thinking to choose signals that are salient from the perspective of the receiver rather than their own point of view. At the neural level, functional magnetic resonance imaging (fMRI) data reveal that the medial prefrontal cortex (mPFC), ventral striatum, and temporal-parietal junction are more activated when signalers engage in allocentric than egocentric thinking. Moreover, functional connectivity between the mPFC and ventral striatum predicted individuals' perspective-taking ability during successful communication. These findings reveal that neural representations in the mPFC-striatum network support perspective-taking in complex social decision making, providing a new perspective on how the brain arbitrates between allocentric thinking and egocentric thinking in communication and social coordination.In arterial spin labeling (ASL) a magnetic label is applied to the flowing blood in feeding arteries allowing depiction of cerebral perfusion maps. The labeling efficiency depends, however, on blood velocity and local field inhomogeneities and is, therefore, not constant over time. In this work, we investigate the ability of statistical methods used in functional connectivity research to infer flow territory information from traditional pseudo-continuous ASL (pCASL) scans by exploiting artery-specific signal fluctuations. U0126 inhibitor By applying an additional gradient during labeling the minimum amount of signal fluctuation that allows discrimination of the main flow territories is determined. The following three approaches were tested for their performance on inferring the large vessel flow territories of the brain a general linear model (GLM), an independent component analysis (ICA) and t-stochastic neighbor embedding. Furthermore, to investigate the effect of large vessel pathology, standard ASL scans of three patients with a unilateral stenosis (>70%) of one of the internal carotid arteries were retrospectively analyzed using ICA and t-SNE.
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