Notes

Unsupervised Learning for Circular Floor Enrollment.
05). RR, MAP, SpO2 and Ramsay sedation score had no significant difference (P>0.05) in DEX group at T1 time point. Compared with MF group, HR significantly decreased and Ramsay sedation score significantly increased(P<0.05); RR, MAP and SpO2 had no significant difference (P>0.05) in DEX group at T2 time point. Compared with T0 time, HR significantly decreased and swallowing time significantly prolonged (P<0.05); RR, MAP and SpO2 had no significant difference(P>0.05) in DEX group at T1 time point. Compared with T1 time, Ramsay sedation score decreased with significant difference(P<0.05) at T2 time point.

Dexmedetomidine can provide good sedative effect for patients with awaking intubation without obvious inhibitory effect on swallowing reflex of patients, improving the safety of intubation.
Dexmedetomidine can provide good sedative effect for patients with awaking intubation without obvious inhibitory effect on swallowing reflex of patients, improving the safety of intubation.
The objective of this study was to detect and analyze the existence of differential metabolites from saliva of patients with oral squamous cell carcinoma(OSCC) by metabonomics method, and to evaluate its application value on clinical diagnosis or screening of OSCC.

The collected saliva samples for OSCC patients, oral leukoplakiac(OLK) patients who were pathologically diagnosed and met the inclusion criteria were analyzed using metabonomics methods (GC-TOF-MS). The results were analyzed by principal component analysis and orthogonal partial least squares discriminant analysis using SIMCA software.

The metabolic profiles of OSCC, OLK and healthy control group showed significant differences (P<0.05). In total, 15 typical differential metabolites among the three groups were detected. Further study focusing on metabolic pathway revealed imbalance of protein, energy and lipid metabolism between OSCC and OLK patients. Abnormal tricarboxylic acid cycle was detected as well.

Metabonomics methods is feasible for differential metabolites analysis,15 differential metabolites were detected in OSCC,OLK patients and healthy people. These findings will contribute to the early screening of oral squamous cell carcinoma.
Metabonomics methods is feasible for differential metabolites analysis,15 differential metabolites were detected in OSCC,OLK patients and healthy people. These findings will contribute to the early screening of oral squamous cell carcinoma.
The aim of this study was to analyze the feasibility of zygomatic implant quad approach in patients with tooth agenesis.

Based on the data from cone-beam CT (CBCT), twenty one patients with tooth agenesis who were planned to receive zygomatic implant quad approach were enrolled. The radiographic bone-to-implant contact (rBIC) of each zygomatic implant placed virtually in patients' zygomatic segment was measured. 17a-Hydroxypregnenolone purchase SPSS 25.0 software package was used for statistical analysis.

Twenty patients' plans of zygomatic implant quad approach were completed (12 men and 8 women). A total of 80 zygomatic implants were placed virtually and the average rBIC of zygomatic segment was (13.85±3.29) mm. The rBIC values of 40 mesial zygomatic implants and 40 distal zygomatic implants were (13.80±3.74) mm and (13.90±2.81) mm, respectively(P>0.05). The average rBIC in male of 24 mesial zygomatic implants and 24 distal zygomatic implants were(14.21±4.08) mm and(14.31±3.18) mm, respectively, slightly higher than those in female of 16 mesial zygomatic implants and 16 distal zygomatic implants, which were (13.18±3.18) mm and (13.29±2.10) mm, respectively. There was no significant difference between the two groups (P>0.05). The average rBIC of 15 extra sinus zygomatic implants, 46 against sinus lateral wall zygomatic implants and 19 intra-sinus zygomatic implants were (16.27±2.95), (13.87±3.10) and (11.88±2.78) mm, respectively. There was significant difference between the extra sinus zygomatic implants and the other two(P<0.05).

It is feasible to plan zygomatic implant quad approach for patients with tooth agenesis. Zygomatic implants can get adequate rBIC in zygomatic segment and to provide sufficient support and retention of the superstructure.
It is feasible to plan zygomatic implant quad approach for patients with tooth agenesis. Zygomatic implants can get adequate rBIC in zygomatic segment and to provide sufficient support and retention of the superstructure.
To investigate the clinical performance of chairside monolithic lithium disilicate glass-ceramics computer-aided design(CAD)-computer aided manufacturing(CAM) crowns, and to analyze the influencing factors of cumulative survival rate.

Two hundred and fourteen patients who had chairside posterior lithium disilicate glass-ceramic CAD-CAM crowns in Peking University Shenzhen Hospital from March 2015 to March 2017 were enrolled. The crown preparations were milled using Cerec Omnicam system. The clinical and esthetic effects of the crowns were analyzed at 3, 6, 12, 24, and 36 months. The cumulative survival rate of crowns was calculated, and the effects of gender, age, pulp condition, tooth position and adhesive type on the cumulative survival rate were analyzed. SPSS 20.0 software package was used for statistical analysis.

After a 36-month follow-up, the failed crowns were mainly caused by marginal integrity, crown fracture and loss of retention. During the observation period of 3, 6, 12, 24 and 36 months, the scores of color, shape, quality of proximal contact, and chewing ability were greater than 9. The cumulative survival rates were 100.00%, 96.17%, 94.89%, 92.77% and 91.06% at 3, 6, 12, 24 and 36 months, respectively. The cumulative survival rate had no significant difference among different gender, age, and dental pulp status(P>0.05).

Chairside monolithic lithium disilicate glass-ceramic CAD-CAM crowns have a high 3-year cumulative survival rate and good esthetic outcome, which is not affected by gender, age, and pulp status with high clinical value.
Chairside monolithic lithium disilicate glass-ceramic CAD-CAM crowns have a high 3-year cumulative survival rate and good esthetic outcome, which is not affected by gender, age, and pulp status with high clinical value.
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