Notes

Oligomerization of p62 permits collection of ubiquitinated freight and also solitude membrane layer throughout selective autophagy.
All three MoCA versions are largely equivalent based on MoCA-TS and the test-retest reliabilities show that this score is suitable to monitor cognitive change over time. Comparisons of the domain-specific scores should be interpreted with caution.Key pointsThe MoCA total score is a reliable cognitive measure.All three MoCA versions are largely equivalent.Age, education and intelligence are predictors of MoCA performance in healthy participants.Future studies should focus on collecting normative data for age, education and intelligence for use in clinical practice.INTRODUCTION The inability to extinguish a conditioned fear is thought to be at the core of post-traumatic stress disorder. Eye movement desensitization and reprocessing therapy has been efficacious for post-traumatic stress disorder, but the brain mechanisms underlying the effect are still unknown. The core effect of eye movement desensitization and reprocessing therapy seems to rely on the simultaneous association of bilateral alternating stimulation and the recall of the traumatic memory. To shed light on how eye movement desensitization and reprocessing therapy functions, we aimed to highlight the structures activated by bilateral alternating stimulation during fear extinction and its recall. METHODS We included 38 healthy participants in this study. Participants were examined twice in functional magnetic resonance imaging, over 2 consecutive days. On the first day, they performed two fear conditioning and extinction procedures, one with and one without the bilateral alternating stimulation during the feashow for the first time that in the eye movement desensitization and reprocessing therapy the bilateral alternating stimulation is not a simple sensory signal and can activate large emotional neural networks.Objective Recent literature has shown a growing interest in the relationship between presbycusis and cognitive decline, but significant evidence about the long-term benefit of rehabilitation on cognitive functions has not been reported yet. The aim of the study was to analyze audiological and neuropsychological performances in patients with cochlear implant (CI) or hearing aids (HAs) over time. Selleck G6PDi-1 Materials and Method Forty-four bilaterally deaf patients aged more than 60 years (25 with CI candidacy and 19 with HA candidacy) were enrolled. Patients were subjected to audiological evaluation, to a battery of neuropsychological tests (Mini-Mental State Examination [MMSE], Rey Auditory Verbal Learning Task [RAVLT], Rey-Osterreith Complex Figure Test, Digit/Corsi Span Forward and Backward, Multiple Features Target Cancellation, Trail-Making Test, Stroop Test, and Phonological and Semantic Word Fluency), and to a quality of life assessment (Short Form 36, Glasgow Benefit Inventory, Glasgow Health Status Inventory) at ry data confirm that hearing deprivation in aged patients represents a truly modifiable risk factor for cognitive decline, which can be positively faced by acoustic rehabilitation. The improvement of short- and long-term memory performances and the amelioration of executive and attentive functions suggest that hearing restoration with both HAs and CI may provide a recovery of superior cognitive domains probably through a reallocation of cortical resources altered by hearing deprivation.Purpose The current study aimed to identify factors that distinguish between older (50+ years) hearing aid (HA) candidates who do and do not purchase HAs after having gone through an HA evaluation period (HAEP). Method Secondary data analysis of the SUpport PRogram trial was performed (n = 267 older, 1st-time HA candidates). All SUpport PRogram participants started an HAEP shortly after study enrollment. Decision to purchase an HA by the end of the HAEP was the outcome of interest of the current study. Participants' baseline covariates (22 in total) were included as candidate predictors. Multivariable logistic regression modeling (backward selection and reclassification tables) was used. Results Of all candidate predictors, only pure-tone average (average of 1, 2, and 4 kHz) hearing loss emerged as a significant predictor (odds ratio = 1.03, 95% confidence interval [1.03, 1.17]). Model performance was weak (Nagelkerke R 2 = .04, area under the curve = 0.61). Conclusions These data suggest that, once HA candidates have decided to enter an HAEP, factors measured early in the help-seeking journey do not predict well who will and will not purchase an HA. Instead, factors that act during the HAEP may hold this predictive value. This should be examined.Speech processing is more effortful under difficult listening conditions. Using a dual-task paradigm, it has been shown that older adults deploy more listening effort than younger adults when performing a speech recognition task in noise. Purpose The primary purpose of this study was to investigate whether a dual-task paradigm could be used to investigate differences in listening effort for an audiovisual speech comprehension task. If so, it was predicted that older adults would expend more listening effort than younger adults. Method Three groups of participants took part in the investigation (a) young normal-hearing adults, (b) young normal-hearing adults listening to the speech material low-pass filtered above 3 kHz, and (c) older adults with age-related normal hearing sensitivity or better. A dual-task paradigm was used to measure listening effort. The primary task consisted of comprehending a short documentary presented at 63 dBA in a background noise that consisted of a 4-talker speech babble presented at 69 dBA. The participants had to answer a set of 15 questions related to the content of the documentary. The secondary task was a tactile detection task presented at a random time interval, over a 12-min period (approximately 8 stimuli/min). Each task was performed separately and concurrently. Results The younger participants who performed the listening task under the low-pass filtered condition displayed significantly more listening effort than the 2 other groups of participants. Conclusion First, the study confirmed that the dual-task paradigm used in this study was sufficiently sensitive to reveal significant differences in listening effort for a speech comprehension task across 3 groups of participants. Contrary to our prediction, it was the group of young normal-hearing participants who listened to the documentaries under the low-pass filtered condition that displayed significantly more listening effort than the other 2 groups of listeners.
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