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Physical Circumventricular Organs, Neuroendocrine Control, and also Metabolism Legislation.
The obtained and thoroughly characterized branched matrices were then used to generate the first β-cyclodextrin/biodegradable polymer/β-blocker conjugate through the successful conjugation of pindolol. The conjugates were fabricated by carbodiimide-mediated coupling reaction. The branched biodegradable materials released the drug in vitro in a sustained manner and without "burst release" and thus have the ability to treat different heart diseases.The purpose of this study was to evaluate changes in the estimated body composition of elite female and male Polish handball players during a five-week preseason training camp. Height and weight were measured, while body composition was estimated with bioelectrical impedance in 18 male and 17 female handball players before and after the five-week training protocol. Components of body composition included total body water (TBW), fat-free mass (FFM), muscle mass (MM), and absolute and relative fat mass (FM). Weight and body mass index (BMI) did not change in males, but declined in females after five weeks of training. FM and %FM declined, while estimated TBW, FFM, and MM increased significantly after training in both males and females. In contrast, comparisons of log transformed ratios for changes in weight, the BMI and body composition in males and females, respectively, suggested that estimated TBW, FFM, and MM increased relatively more in females than in males, while FM and %FM decline relatively more in males than females. Overall, the five-week preseason training program modified the body composition of male and female handball players. FM and %FM decreased, while estimated TBW, FFM, and MM increased, in both males and females after the preseason training program. Comparisons of log transformed ratios for changes in body composition in males and females suggested sexual dimorphism in response to intensive preseason training.Acetone is a well-known volatile organic compound that is widely used in different industrial and domestic areas. However, it can have dangerous effects on human life and health. Thus, the realization of sensitive and selective sensors for recognition of acetone is highly important. Among different gas sensors, resistive gas sensors based on nanostructured metal oxide with high surface area, have been widely reported for successful detection of acetone gas, owing to their high sensitivity, fast dynamics, high stability, and low price. Herein, we discuss different aspects of metal oxide-based acetone gas sensors in pristine, composite, doped, and noble metal functionalized forms. Gas sensing mechanisms are also discussed. This review is an informative document for those who are working in the field of gas sensors. Pyrrolomycins (PMs) are polyhalogenated antibiotics known as powerful biologically active compounds, yet featuring high cytotoxicity. The present study reports the antibacterial and antitumoral properties of new chemically synthesized PMs, where the three positions of the pyrrolic nucleus were replaced by nitro groups, aiming to reduce their cytotoxicity while maintaining or even enhancing the biological activity. Indeed, the presence of the nitro substituent in diverse positions of the pyrrole determined an improvement of the minimal bactericidal concentration (MBC) against Gram-positive (i.e., Staphylococcus aureus) or -negative (i.e., Pseudomonas aeruginosa) pathogen strains as compared to the natural PM-C. Moreover, some new nitro-PMs were as active as or more than PM-C in inhibiting the proliferation of colon (HCT116) and breast (MCF 7) cancer cell lines and were less toxic towards normal epithelial (hTERT RPE-1) cells. Altogether, our findings contribute to increase the knowledge of the mode of action of these promising molecules and provide a basis for their rationale chemical or biological manipulation.The principal objective of this study is to improve the diagnostics of power transformers, which are the key element of supplying electricity to consumers. On Load Tap Changer (OLTC), which is the object of research, the results of which are presented in this article, is one of the most important elements of these devices. RRx001 The applied diagnostic method is the acoustic emission (AE) method, which has the main advantage over others, that it is considered as a non-destructive testing method. At present, there are many measuring devices and sensors used in the AE method, there are also some international standards, according to which, measurements should be performed. In the presented work, AE signals were measured in laboratory conditions with various OLTC defects being simulated. Five types of sensors were used for the measurement. The recorded signals were analyzed in the time and frequency domain and using discrete wavelet transformation. Based on the results obtained, sets of indicators were determined, which were used as features for an autonomous classification of the type of defect. Several types of learning algorithms from the group of supervised machine learning were considered in the research. The performance of individual classifiers was determined by several quality evaluation measures. As a result of the analyses, the type and characteristics of the most optimal algorithm to be used in the process of classification of the OLTC fault type were indicated, depending on the type of sensor with which AE signals were recorded.This year marks 30 years of close collaboration between a consortium of institutions, namely, the Northwest Public Health Research Center, Saint-Petersburg (NWPHRC); the Institute of Community Medicine (ICM) of UiT (The Arctic University of Norway, Tromsø); the National Institute of Occupational Health (NIOH), Oslo; the University Hospital of Northern Norway (UNN) at Tromsø; and McMaster University (MU), Hamilton, ON, Canada. During the early years of cooperation, Dr. Chashchin was the Director of the Scientific Laboratory of the North-West Public Health Centre Branch of the NWPHRC located in the town of Kirovks in the Murmansk Region. The primary focus of this long-standing collaboration was to assess and address issues that are important for maintaining the health of the population living in the border areas of Russia and Norway and included the reduction of occupational health risks among workers employed in mining, metallurgical and machine-building enterprises located in the north-western region of Norway and the adjoining Kola Peninsula in Russia.
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