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Nanodiagnostics to Face SARS-CoV-2 and also Long term Epidemics: Via a perception to the Marketplace and Outside of.
Endogenous retroviruses (ERVs) are retrotransposons present in various metazoan genomes and have been implicated in metazoan evolution as well as in nematodes and humans. The long terminal repeat (LTR) retrotransposons contain several regulatory sequences including promoters and enhancers that regulate endogenous gene expression and thereby control organismal development and response to environmental change. ERVs including the LTR retrotransposons constitute 8% of the human genome and less than 0.6% of the Caenorhabditis elegans (C. elegans) genome, a nematode genetic model system. To investigate the evolutionarily conserved mechanism behind the transcriptional activity of retrotransposons, we generated a transgenic worm model driving green fluorescent protein (GFP) expression using Human endogenous retroviruses (HERV)-K LTR as a promoter. The promoter activity of HERV-K LTR was robust and fluorescence was observed in various tissues throughout the developmental process. Interestingly, persistent GFP expression was specifically detected in the adult vulva muscle. Using deletion constructs, we found that the region from positions 675 to 868 containing the TATA box was necessary for promoter activity driving gene expression in the vulva. Interestingly, we found that the promoter activity of the LTR was dependent on che-1 transcription factor, a sensory neuron driver, and lin-15b, a negative regulator of RNAi and germline gene expression. These results suggest evolutionary conservation of the LTR retrotransposon activity in transcriptional regulation as well as the possibility of che-1 function in non-neuronal tissues. [BMB Reports 2020; 53(10) 521-526].The purpose of this study was to determine what differences exist when performing grand plié with and without the barre. Differences in center of pressure (COP) sway, trunk kinematics, and lower extremity kinematics were used in this analysis for both first (P1) and fifth positions (P5). It was hypothesized that use of the barre would result in decreased COP sway, but increased asymmetries in trunk and lower extremity kinematics would be seen compared with the same movements performed without the barre in both positions. M4344 concentration Sixteen collegiate dancers (1 male, 15 female) performed three trials of grand plié in P1 and P5 (right leg crossed in front) with or without the barre, for a total of 12 trials. For the barre condition (BC), participants demonstrated less time to complete grand plié, slightly less depth in grand plié, and decreased anterior-posterior (AP) sway compared to the without barre condition (WBC). The BC condition showed increased peak left trunk rotation, right knee flexion, decreased right and left peak hip flexion, and increased right hip abduction in both P1 and P5. Comparing P1 to P5, there was decreased AP sway, decreased peak left trunk rotation, decreased peak right and left hip flexion, increased left hip abduction, and decreased right knee flexion in both BC and WBC conditions. For the BC, there was increased right hip abduction in P1 compared to P5. Our results indicate that while use of the barre provides proprioceptive information, which helps dancers to control balance and learn a motor control strategy, grand plié should also be taught without the barre to challenge the dancer's balance control with different movement patterns in space.This mixed methods study compared the impact of studio mirrors on body image in beginning level female collegiate modern dance and ballet students utilizing the Cash 69-item Body Self-Relations Questionnaire and semi-structured interviews. For the overall Body-Areas Satisfaction there was a statistically significant mirror condition x time interaction (p = 0.029); regardless of dance genre, students' body satisfaction in mirrored classes decreased. Specifically at the mid torso, a statistically significant class type x time interaction (p = 0.012) occurred; ballet dancers decreased in satisfaction. Interviews reflected that 1. students in the mirrored classes spent more time discussing specific body parts with objectifying language; and 2. students in the non-mirrored classes spent more time describing their participation in dance in terms of kinesthetic sensations. These findings suggest that satisfaction with one's body in beginner ballet and modern classes may be compromised by the use of mirrors.Dancers have unique health issues, including high injury rates and functional, nutritional, and psychological concerns. Thererfore, developing dancers with high health literacy is crucial. This study examines 1. the types of health-related information offered in university dance programs, and 2. the perceptions of dance stakeholders (administrators, faculty, and students) toward health-related education provided to dancers in these programs. Participating stakeholders (N = 104) from 11 countries completed a web-based survey examining health-related offerings for dance students at their instituitions. Eighty-four participants (81%) indicated that health-related information was delivered at their instituition. The most commonly offered topics included functional dance anatomy (N = 82, 98%), recognizing dance injuries and illnesses (N = 66, 79%), and strength and conditioning for dancers (N = 61, 73%). Participants rated recognizing dance injuries and illnesses (N = 72, 69%), basic personal health (N = 70, 67%),status of health-related education provided to dance students and can be used to improve curricula in university dance programs.It is well known that sex differences exist in landing biomechanics in athletes, and these differences are purported to underlie a prevalence of traumatic knee injuries in females compared to males. However, it remains unknown if these differences also apply to artistic athletes such as dancers. The purpose of this study was to investigate sex differences in ground reaction forces (GRFs) between male and female dancers during single- and double-leg dance-specific landing movements. Fourteen pre-professional and professional ballet dancers (seven female and seven male) performed grand jeté (single-leg landing) and sauté (double-leg landing) jumps onto two force platforms. Visual3D was used to calculate the resulting GRF time-series, and MAT-LAB to select discrete variables of interest including peak vertical GRF, loading rate, landing duration, and vertical impulse. Paired t-tests were used to compare mean GRF variables between male and female dancers. During single-leg landing male dancers had smaller peak vertical GRFs (p less then 0.
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