Notes

Dispositional desire as being a probable outcome parameter between people together with superior metastasizing cancer: A good investigation ENABLE repository.
Sequential thickness plots from four parafoveal cases showed dramatic retinal thinning across the posterior pole beginning 4 years to 5 years before clinical diagnosis, with parafoveal regions thinning even faster. The pericentral case showed thinning only outside the central macula. Peripheral EZ loss was more dramatic with EZ topography than sdOCT cross-sections.

Sequential retinal thickness plots reveal definitive thinning years before current diagnostic procedures. We hope that OCT manufacturers will develop software to display such measurements. Ellipsoid zone topography was not more sensitive than sdOCT cross-sections, but important for recognizing pericentral disease.
Sequential retinal thickness plots reveal definitive thinning years before current diagnostic procedures. We hope that OCT manufacturers will develop software to display such measurements. Ellipsoid zone topography was not more sensitive than sdOCT cross-sections, but important for recognizing pericentral disease.
To describe the peripheral optical coherence tomography (OCT) findings in a female choroideremia carrier.

Case report.

A 56 year-old woman was referred for visual disturbance complaining of some occasional photopsias and increasing difficulty with her vision at night in both eyes. Best-corrected visual acuity was 20/20 in the right eye and 20/150 in the left eye. Fundus examination revealed mildly tilted disks and peripapillary atrophy with subtle retinal pigment epithelial changes in the periphery.

Macular OCT in the right eye appeared unremarkable but the in the left eye there was diffuse ellipsoid zone (EZ) band disruption. Green-light fundus autofluorescence (FAF) revealed mottled areas of decreased AF in the mid and far periphery creating an irregular mosaic pattern. selleckchem Peripheral OCT scans revealed more diffuse EZ alterations than were apparent on the FAF imaging. Genetic testing revealed a heterozygous pathogenic variant in the CHM gene (c.715C>T, p.Arg239). An additional heterozygous mutation was noted in the CNGB1 gene (c.290+2T>C, splice donor).

Choroideremia carriers may manifest widespread photoreceptor alterations which may be more extensive than apparent on FAF imaging.
Choroideremia carriers may manifest widespread photoreceptor alterations which may be more extensive than apparent on FAF imaging.
To report a case of a pituitary macroadenoma that presented with bilateral intraretinal hyporeflective spaces located primarily in the inner nuclear layer in the macular SD-OCT.

Case report.

Based on the findings of a macular SD-OCT, a 53-year-old man was considered as having cystoid macular edema secondary to a retinovascular condition. He was treated with intravitreal VEGF inhibitors and corticosteroids with no improvement. Confrontation visual fields suggested a bitemporal defect. MRI confirmed the presence of a non-secreting pituitary macroadenoma compressing the optic chiasm.

Not all intraretinal hyporeflective spaces in the OCT are secondary to a retinal vascular condition. Hyporeflective spaces in the INL on OCT imaging that do not leak on fluorescein angiography may be secondary to optic atrophy from chiasmal compression.
Not all intraretinal hyporeflective spaces in the OCT are secondary to a retinal vascular condition. Hyporeflective spaces in the INL on OCT imaging that do not leak on fluorescein angiography may be secondary to optic atrophy from chiasmal compression.
Traumatic optic neuropathy can have varying presentations. Blunt focal trauma can lead to optic nerve avulsion with underlying retinal findings. We report a case of partial optic nerve avulsion after finger poke injury leading to focal retinal ischemia.

Visual acuity, fundus photography with fluorescein angiography (FA), and spectral domain optical coherence tomography (SD-OCT) were performed to document the findings in a 16-year-old male who presented after a finger poke injury to the left orbit during a water polo match.

On initial presentation, exam revealed decreased visual acuity with a fixed left pupil and afferent pupillary defect by reverse. On slit lamp exam of the left eye a hyphema was present. Dilated fundus exam revealed layering vitreous hemorrhage over the posterior pole and an avulsed vitreous base. On follow-up, a gap temporal to the optic nerve head consistent with a partial optic nerve avulsion was noted once the vitreous hemorrhage cleared. Multimodal imaging revealed retinal ischemia temporal to the disc on FA with corresponding changes in the inner retinal layers and retinal nerve fiber layer using SD-OCT.

Clinicians should have a high suspicion for optic nerve avulsion if a patient presents with new vitreous hemorrhage and APD after a finger-poke injury. Optic nerve avulsion injury can cause retinal ischemia, likely due to interruption of retinal blood flow as a result of nerve shearing injury. Multi-modal imaging can reveal focal retinal injury and aid in proper diagnosis and follow-up.
Clinicians should have a high suspicion for optic nerve avulsion if a patient presents with new vitreous hemorrhage and APD after a finger-poke injury. Optic nerve avulsion injury can cause retinal ischemia, likely due to interruption of retinal blood flow as a result of nerve shearing injury. Multi-modal imaging can reveal focal retinal injury and aid in proper diagnosis and follow-up.
To report a case of Vogt-Koyanagi-Harada (VKH)-like uveitis followed by melanoma-associated retinopathy (MAR) with focal chorioretinal atrophy and subsequent choroidal neovascularization (CNV) in a patient with metastatic cutaneous melanoma.

A 68-year-old man with a history cutaneous melanoma presented with VKH-like uveitis. Work up revealed a pelvic mass, which was excised and found to be metastatic melanoma. Two years later, the patient developed MAR with focal chorioretinal atrophy and adjacent CNV.

and Importance Patients with metastatic cutaneous melanoma can develop distinct and sequential paraneoplastic ocular complications. Onset of a VKH-like uveitis may be a good prognostic factor for survival in patients with metastatic cutaneous melanoma.
and Importance Patients with metastatic cutaneous melanoma can develop distinct and sequential paraneoplastic ocular complications. Onset of a VKH-like uveitis may be a good prognostic factor for survival in patients with metastatic cutaneous melanoma.
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