Notes

Posttreatment after Lenvatinib in Individuals using Sophisticated Hepatocellular Carcinoma.
Findings can inform future interventions during SCI rehabilitation to ease transitions and decrease anxiety following SCI.
Increasing evidence views hypertension as a stress-induced disorder. Stressors must be "gated" by the brain before any inflammatory or immune processes that contribute to hypertension are initiated. No studies were found that examined sensory gating in relation to hypertension.

The aim of the study was to determine if disturbances in self-reported sensory gating could differentiate normotensive from hypertensive young adults.

A nonmatched, case-control design was used. We administered an online survey to 163 young adult participants. Participants were predominantly female, in their mid-20s, well educated, and approximately evenly distributed by race and hypertension status. The Sensory Gating Inventory (SGI) measured gating disturbances.

The mean SGI scores were significantly higher among persons diagnosed with hypertension, reflecting a moderate effect size of sensory gating. After adjusting for confounders, however, the normotensive and hypertensive groups were not significantly different on their SGI scores.

With an observed moderate effect size of 0.35, but low power, more research is warranted regarding the role of gating disturbances in the development of stress-induced hypertension. Clinically, the SGI may be important for screening patients who would benefit from ambulatory blood pressure monitoring to identify persons with masked hypertension.
With an observed moderate effect size of 0.35, but low power, more research is warranted regarding the role of gating disturbances in the development of stress-induced hypertension. Clinically, the SGI may be important for screening patients who would benefit from ambulatory blood pressure monitoring to identify persons with masked hypertension.Whinton, AK, Donahoe, K, Gao, R, Thompson, KMA, Aubry, R, Saunders, TJ, Johnston, A, Chilibeck, PD, and Burr, JF. Repeated application of a novel creatine cream improves muscular peak and average power in male subjects. J Strength Cond Res 34(9) 2482-2491, 2020-Using a multicenter, randomized controlled trial, (N = 123, age 23 ± 4 years) we sought to determine whether administration of a novel, topical creatine supplement could improve muscular performance after acute and repeated (7-day) exposure. To study the acute performance enhancing effects of the supplement, subjects completed 5 sets of 15 maximal concentric single-leg knee extensions with and without the application of a low- (low dose [LD]-3.5 ml) or high-dose (high dose [HD]-7 ml) topical creatine cream. After a wash-out period, subjects had one leg randomized to receive either the creatine or placebo cream, with further randomization into an oral creatine or placebo supplement group. Subjects completed 5 sets of 15 maximal concentric single leg knef application.Bohannon, NA, Gillen, ZM, Shoemaker, ME, McKay, BD, Gibson, SM, Cramer, JT. Test-Retest Reliability of Static and Counter-Movement Power Push-Up Tests in Young Male Athletes. J Strength Cond Res 34(9) 2456-2464, 2020-The primary purpose of this study was to evaluate test-retest reliability of the static (SP) and countermovement (CMP) power push-up test in young male athletes. The secondary purpose was to compare the reliability of vertical ground reaction forces versus torque measurements during the power push-up tests. Twenty boys (age = 11.60 ± 1.15 years) performed SPs and CMPs on force plates with the knees as the fulcrum on 2 laboratory visits separated by 2-7 days. Performance measurements included peak force (PF), peak rate of force development (pRFD), peak torque (PT), peak rate of torque development (pRTD), peak power (PP), average power (AP), eccentric impulse (ECC), and concentric impulse (CON) for both power push-up techniques. Age, maturity offset, height, body mass, fat-free mass, and estimated arm cross sectional area were obtained as measurements of growth. Intraclass correlation coefficients (ICC), SEM, coefficients of variation, and minimum detectable changes (MDC) were reported. Only PF (ICC = 0.87-0.88, SEM = 59-84 N) and PT (ICC = 0.89-0.90, SEM = 60-88 N·m) showed acceptable reliability. Neither pRFD, pRTD, PP, AP, ECC, or CON were reliable outcomes. There were no meaningful differences between force-time and torque-time curve measurements. INCB024360 ic50 The SP showed slightly lower CVs (33-34%) than the CMP (CVs = 39-40%). Coaches and practitioners would need to see 58-71% increases in upper-body strength measurements evaluated via power push-up on force plates to be 95% confident that the improvements exceeded the measurement variability.Latella, C, Teo, W-P, Spathis, J, and van den Hoek, D. Long-term strength adaptation A 15-year analysis of powerlifting athletes. J Strength Cond Res 34(9) 2412-2418, 2020-Strength is a fundamental component of athletic performance and development. This investigation examined the long-term strength development of powerlifting (PL) athletes. The rate of strength gain/day was assessed in 1897 PL athletes (F = 626, M = 1,271) over a 15-year period (2003-2018). Independent T-tests explored sex differences in baseline absolute (kg) and relative strength (kg·body mass [bm]) recorded from the first competition, and strength gain/day (kg·d). Analyses based on initial strength quartiles were conducted using one-way analysis of variances with significance set at p less then 0.05. Bivariate correlational analysis tested for relationships between strength gain/day and baseline strength, the number of competitions, and mean days between competitions. Males had greater absolute (M 513.3 ± 99.8 kg, F 289.4 ± 55.7 kg, p lh adaptations that may be particularly useful to understand athlete development, to aid periodized programming, and to benchmark strength over time.Merrigan, JJ, Dabbs, NC, and Jones, MT. Isometric mid-thigh pull kinetics Sex differences and response to whole-body vibration. J Strength Cond Res 34(9) 2407-2411, 2020-The purpose was to investigate whether whole-body vibration's (WBV's) effect on force-time characteristics is dependent on time and sex. Subjects (men, n = 18; women, n = 18) performed a static quarter squat with WBV (frequency 30 Hz; amplitude 2-4 mm) and without for 5 × 30 seconds repetitions (11, WBVrest). Next, they performed 2 sets of 3 repetitions of the isometric mid-thigh pull (IMTP) with 3 minutes of intraset rest and 5 minutes of interset rest. Peak force (PF) and rate of force development (RFD) from 0 to 50, 0 to 150, and 0 to 250 milliseconds (RFD50, RFD150, and RFD250) were analyzed (p less then 0.05). A significant effect of condition existed for PF (p = 0.019) and RFD from 0 to 250 seconds (p = 0.031). In women, RFD was moderately affected immediately post-WBV (p = 0.070; d = 0.49). Yet in men, the effect of WBV on RFD existed 15 minutes after exposure (p = 0.
Homepage: https://www.selleckchem.com/products/epacadostat-incb024360.html