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We found age-related changes in monocyte metabolic fitness, including reduced mitochondrial function and increased glycose consumption without the capacity to upregulate it during increased metabolic needs, and signs of increased oxidative stress and DNA damage. In conclusion, our results complement existing findings and elucidate the metabolic alterations that occur in monocytes during aging. © 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.This work reports development of yttrium doped copper oxide (Y-CuO) as a new hole transport material with supplemented optoelectronic character. The pure and Y-CuO thin films are developed through solid state method at 200oC and recognized as high performance p-channel inorganic thin-film transistors (TFTs). In sharp contrast, CuO is formed by oxidative decomposition of copper acetylacetonate yielding 100nm thick and 40.9 Scm-1 conductive compact layer of 2.47 eV band gap and ~1.44 × 1019 cm-3carrier density. Yttrium doping generates denser layer, Cu2Y2O5 phase in the lattice, of wide band gap, 2.63 eV. The electrical conductivity increases nine fold on 2% Y addition to CuO and carrier density becomes 2.97 × 1021 cm-3, the highest reported so far. The TFT devices perform remarkably with high field-effect mobility (µsat) of 3.45 cm2V-1s-1 and 5.3 cm2V-1s-1, and considerably high current-on/off ratio 0.11 × 104 and 9.21 × 104, for CuO and Y-CuO films, respectively at -1V operating voltage. A very small width hysteresis, 0.01 (CuO) and 1.92V (1% Y-CuO) depict good bias stability. Both the devices work in enhancement mode with stable output characteristics for multiple forward sweeps (5 to -60V) at -1Vg. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.OBJECTIVE In patients with asthma and chronic obstructive pulmonary disease (COPD), disease control is still suboptimal-incorrect inhalation technique and medication non-adherence are two important reasons for this outcome. Pharmacists' interventions have been shown to have a positive effect on the clinical outcomes of asthma and COPD. Quantitative assessment of the efficacy of pharmacist-led interventions, mainly on inhalation techniques and medication adherence, is needed. Evidence for different interventions is not totally conclusive, and no results of theory-based adherence promotion interventions for asthma and COPD have been published. Selleck AZD0095 The objective of our study is to evaluate the effect of pharmacist-led interventions on asthma and COPD management, focusing mainly on inhalation technique and medication adherence, and whether the content of interventions (categorized based on Information-Motivation-Behavioural skills (IMB) model) affects the effectiveness and whether the IMB model is worthy of clinical nd uniform measurement of medication adherence. © 2020 John Wiley & Sons Ltd.AIM Few studies have comprehensively evaluated the factors associated with health-related quality of life (HRQOL) in the elderly. The purpose of the study is to identify the factors associated with HRQOL using a comprehensive geriatric assessment of community-dwelling elderly people in Beijing, China. METHODS A cross-sectional survey of 896 community-dwelling elderly people in Beijing was conducted through face-to-face interviews. Data regarding sociodemographic factors, chronic disease (assessed by the Cumulative Illness Rating Scale for Geriatrics, CIRS-G), common geriatric syndromes and HRQOL (assessed by the EuroQol 5-Dimension questionnaire, EQ-5D) were collected using a structured questionnaire. Binary logistic regression analysis was used to identify the factors related to HRQOL. RESULTS The CIRS-G comorbidity index was negatively related to the EQ-5D index and EQ-Visual Analog Scale (VAS) (P less then 0.05). Geriatric syndromes such as chronic pain and non-optimal nutrition were negatively related to HRQOL (P less then 0.05), and the negative influence of geriatric syndromes on the EQ-5D index was stronger than that of the cumulative comorbidities. Functional status in daily living activities was positively related to HRQOL (P less then 0.05). Receiving care from children was positively related to EQ-VAS (P less then 0.05). CONCLUSIONS Besides cumulative comorbidities and geriatric syndromes, in particular nutritional problems and chronic pain exert a substantial negative impact on the HRQOL of elderly people in China, whereas family support is an important protective factor. Geriatr Gerontol Int 2020; •• ••-••. © 2020 Japan Geriatrics Society.The ongoing interest in colloidal nanocrystal solids for electronic and photonic devices necessitates that their thermal transport properties be well understood because heat dissipation frequently limits performance in these devices. Unfortunately, colloidal nanocrystal solids generally possess very low thermal conductivities. This very low thermal conductivity primarily results from the weak van der Waals interaction between the ligands of adjacent nanocrystals. We overcome this thermal transport bottleneck by crosslinking the ligands, which exchanges a weak van der Waals interaction with a strong covalent bond. We obtain thermal conductivities of up to 1.7 Wm -1 K -1 that exceed prior reported values by a factor of 4. This improvement is significant because the entire range of prior reported values themselves only span a factor of 4 (i.e., 0.1 - 0.4 Wm -1 K -1 ). We complement our thermal conductivity measurements with mechanical nanoindentation measurements that demonstrate ligand crosslinking increases Young's modulus and sound velocity. This increase in sound velocity is a key bridge between mechanical and thermal properties because sound velocity and thermal conductivity are linearly proportional according to kinetic theory. Control experiments with non-crosslinkable ligands as well as transport modeling further confirm ligand crosslinking boosts thermal transport. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.This study aimed to explore the outcomes of active participation in an action research project on building the research capacity of clinical nurses. In this qualitative research study, six registered nurses volunteered to participate in the action research team. None of the nurses reported having any prior research experience. This study was part of a larger three-phase project. The nurses were required to reflect on the data about their medication practice of phase 1, develop and implement a bundle of interventions in phase 2 to improve medication safety, and evaluate the effectiveness of these interventions in phase 3. We report the nurses' participation in Action Research during phase 2. Meeting minutes and six semistructured interviews were thematically analyzed. The results showed that after receiving support to enhance their research skills from the research team, the nurses were empowered to perform and lead clinical nursing research project. Nurses were able to take ownership of the research process and outcomes and were then able to translate their new research knowledge and skills into their clinical practice by building their own research capacity.
Website: https://www.selleckchem.com/products/azd0095.html
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