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[A case of oculocutaneous albinism along with cataract].
The application of Raman spectroscopy confirmed the involvement of the C=O group in the formation of hydrogen bonds between the (-)-epicatechin and barbituric acid molecules. Additionally, the solubility studies of pure EC and the EC-BTA cocrystal exhibited minor enhancement of EC solubility in the buffer solution, and pH measurements confirmed a stable level of solubility for EC and its cocrystal.Injecting nitrogen into goaf has been widely adopted for preventing fire hazards in coal mines. In this paper, the coupling relation between different locations of negative pressure of cross-cut drainage and nitrogen injection was investigated. The minefield data collection was carried out by an in situ beam tube system on the intake airway and return airway of the mine goaf. The validated Computational Fluid Dynamics (CFD) model that was secondarily modified by on-site collected data was applied for further research. It is demonstrated that the area of the spontaneous combustion zone generally shows a sharp decline first, then tends to stabilize, and finally has a slight drop and rise with the increasing nitrogen injection time. It is obvious that the location of the negative pressure of cross-cut exerts a significant influence on the optimal nitrogen injection location and time. When the cross-cut is located in the center of the air leakage zone, spontaneous combustion zone, and asphyxiation zone of goaf, the optimal nitrogen injection location and time correspond to the P2 (25 m, 1200 min), P3 (30 m, 120 min), and P4 (35m, 1800 min), respectively. According to the simulation result, the specific relation between the optimal nitrogen injection point N(x) and the distance from the working distance of the cross-cut (x) by Newton interpolation polynomial analysis was figured out and verified that N(x) = 24.70808 + 0.293356x - 0.001436x 2. It is hoped that the result can provide scientific guidance for coal mine fire prevention and control with nitrogen injection.Fluid homogeneity and stability are of high importance as they greatly affect the fluid performance in drilling operations. Solid settlement or solid sag is a severe issue that occurs in weighted drilling muds, especially at elevated temperatures, where the weight material tends to settle down causing well control problems. This study evaluates the effectiveness of a synthetic clay (laponite) to prevent the static and dynamic sag tendency of barite-weighted drilling fluid for elevated-temperature drilling applications. Several high-density mud samples were prepared by varying the concentration of the synthetic clay. The sag tendency of the fluid samples was evaluated in the lab using dynamic and static sag tests, and the optimal concentration was determined. The impact of synthetic clay on the density, pH, and rheological properties was also studied. Moreover, the filtration properties of the developed formulation were measured using high-pressure high-temperature filtration experiments. The synthetic clay was found to be effective in reducing the static and dynamic sag tendency of barite-weighted water-based drilling fluids. 0.75 lb/bbl of laponite was adequate to eliminate solid sag at a temperature up to 250 F. This amount of laponite slightly increased the plastic viscosity by 8%, while an increase of 42% and 43-115% in the yield point and gel strength, respectively, was observed. A significant enhancement in the filtration performance was observed; the filter cake thickness and the filtrate volume were decreased by 15-20%. Additionally, the synthetic clay had an insignificant effect on the fluid density and pH.Bacterial exopolysaccharides (EPSs) are important alternatives to plant polysaccharides in fermented products and exhibit antioxidant activity, which is particularly desirable for functional foods. This study evaluated the use of spent media wastewater (SMW) derived from kimchi fermentation for the production of an EPS and analyzed the characterization and antioxidant activity of the resulting EPS. The EPS concentration and conversion yields of sequential purification were 7.7-9.0 g/L and 38.6-45.1%, respectively. Fourier transform infrared spectra and NMR spectra indicated that the EPS was a linear glucan with α-(1 → 6) linkages. The EPS also exhibited thermal tolerance to high temperatures. In vitro antioxidant activity analyses indicated the scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, thiobarbituric acid reactance (TBAR), and ferric ion reducing antioxidant power (FRAP) values of 71.6-79.1, 28.2-33.0%, and 0.04-0.05 mM FeCl3, respectively. These results reveal that the EPS extracted from SMW has potential as a thermally tolerant, nontoxic, and natural antioxidant for industrial applications.Arylsulfatase and β-glucuronidase are two important enzymes in humans, which play an important role in the dynamic equilibrium of steroidal estrogens. This work probably for the first time reported that hydrogen peroxide (H2O2), hypochlorite, and peracetic acid (PAA) could effectively inhibit the activities of arylsulfatase and/or β-glucuronidase. The 50% of inhibitions (IC50) of H2O2, hypochlorite, and PAA on arylsulfatase were found to be 142.90 ± 9.00, 91.83 ± 10.01, and 43.46 ± 2.92 μM, respectively. The corresponding IC50 values of hypochlorite and PAA on β-glucuronidase were 704.90 ± 41.40 and 23.26 ± 0.82 μM, whereas H2O2 showed no inhibition on β-glucuronidase. The inhibitions of arylsulfatase and/or β-glucuronidase by these three chemicals were pH-dependent. It was further revealed that the inhibitions of hypochlorite on both arylsulfatase and β-glucuronidase were irreversible. Bafilomycin A1 nmr On the contrary, the inhibitions by H2O2 and PAA were reversible. In addition, the inhibition by H2O2 was competitive and that by PAA was noncompetitive. In general, H2O2 and hypochlorite can be endogenously produced in humans, which suggested that the two compounds are potential endocrine disruption compounds (EDCs) as they can cause endocrine disruption via the inhibition of arylsulfatase and β-glucuronidase. This work further indicated that any agent that can induce the production of H2O2 or hypochlorite in humans is a potential EDC, which explains why some EDCs with very weak or no estrogenic potency can cause endocrine disruption, which is confirmed in epidemiological studies.
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