Notes

Group Variants Specialized medical Display of Pediatric Paradoxical Singing Retract Motion (PVFM).
The TS and DTP groups showed less and shorter SWDs in later life in comparison to maternally separated and control rats. SWDs' number and total duration were significantly reduced in TS and DTP groups whereas mean duration of SWDs was reduced only in DTP group (p less then 0.05). TS and DTP also decreased depression-like behaviors measured by SCT and FST in adult animals. In the SCT, number of approaches was significantly higher in TS and DTP groups than the maternally separated and control rats. In the FST, while the immobility latency of TS and DTP groups was significantly higher, only TS group showed significantly decreased immobility and increased swimming time. The results showed that NTS decreases both the number and length of SWDs and the depression-like behaviors in WAG/Rij rats probably by increasing arousal level and causing alterations in the level of some neurotrophic factors as well as in functions of the neural plasticity in the developing rat's brain.Chronic stress during the developmental period of adolescence increases susceptibility to many neuropsychiatric diseases in adulthood, including anxiety, affective, and alcohol/substance use disorders. Preclinical rodent models of adolescent stress have produced varying results that are species, strain, sex, and laboratory-dependent. However, adolescent social isolation is a potent stressor in humans that has been reliably modeled in male rats, increasing adult anxiety-like and alcohol drinking behaviors, among others. In this study, we examined the generalizability and sex-dependence of this model in C57BL/6J mice, the most commonly used rodent strain in neuroscience research. We also performed a parallel study using social isolation in adulthood to understand the impact of adult social isolation on basal behavioral phenotypes. We found that 6 weeks of social isolation with minimal handling in adolescence through early adulthood [postnatal day (PD) 28-70] produced a hypersocial phenotype in both male and female mice and an anxiolytic phenotype in the elevated plus-maze in female mice. However, it had no effects in other assays for avoidance behavior or on fear conditioning, alcohol drinking, reward or aversion sensitivity, or novel object exploration in either sex. In contrast, 6 weeks of social isolation in adulthood beginning at PD77 produced an anxiogenic phenotype in the light/dark box but had no effects on any other assays. Altogether, our results suggest that (1) adolescence is a critical period for social stress in C57BL/6J mice, producing aberrant social behavior in a sex-independent manner; and (2) chronic individual housing in adulthood does not alter basal behavioral phenotypes that may confound interpretation of behavior following other laboratory manipulations.According to the triangular theory of love, passion is an indispensable component of romantic love. Some brain imaging studies have shown that passionate arousal in intimate relationships is associated with the reward circuits in the brain. We hypothesized that the individual reward sensitivity trait is also related to passion in intimate relationships, and two separate studies were conducted in the present research. In the first study, 558 college students who were currently in love were selected as participants. The correlation between intimacy and reinforcement sensitivity in individuals identifying as heterosexual was explored using the Sensitivity to Punishment and Sensitivity to Reward Questionnaire, the Passionate Love Scale, and the Triangular Love Scale. In the second study, participants were 42 college students who were also currently in love. Functional near-infrared spectroscopy (fNIRS) was adopted to explore the neurophysiological interaction between reward sensitivity and emotional arousal induced in participants when presented a photograph of their partner, a friend, or a stranger. The results showed that reward sensitivity was positively correlated with passion, and punishment sensitivity was negatively correlated with intimacy and commitment. Significant interactions between reward sensitivity and photograph type were found, and the triangular part of the inferior frontal gyrus showed a particular relevance to the reward-sensitive personality trait toward partners. Overall, the findings support reinforcement sensitivity theory and suggest that reinforcement-sensitive personality traits (personality traits of reward and punishment sensitivity) are associated with all three components of love, with only reward sensitivity being related to passion.The behavior of an animal has substantial effects on its metabolism. Such effects, including changes in the lipid composition of different organs, or changes in the turnover of the proteins, have typically been observed using liquid mass spectrometry methods, averaging the effect of animal behavior across tissue samples containing multiple cells. These methods have provided the scientific community with valuable information, but have limited resolution, making it difficult if not impossible to examine metabolic effects at the cellular and subcellular levels. Recent advances in the field of secondary ion mass spectrometry (SIMS) have made it possible to examine the metabolic effects of animal behavior with high resolution at the nanoscale, enabling the analysis of the metabolic effects of behavior on individual cells. In this review we summarize and present these emerging methods, beginning with an overview of the SIMS technique. We then discuss the specific application of nanoscale SIMS (NanoSIMS) to examine cell behavior. This often requires the use of isotope labeling to highlight specific sections of the cell for analysis, an approach that is presented at length in this review article. We also present SIMS applications concerning animal and cell behavior, from development and aging to changes in the cellular activity programs. We conclude that the emerging group of SIMS technologies represents an exciting set of tools for the study of animal behavior and of its effects on internal metabolism at the smallest possible scales.Non-motor symptoms of Parkinson's disease (PD) are of increasing interest in clinical and psychological research. Disinhibition-the inability to inhibit inappropriate behavior-leads to social and emotional impairments, including impulsive behavior and disregard for social conventions and decision-making behavior. In recent years, the latter has been investigated using economic exchanges during social interactions. Altruistic punishment-to punish someone who violates group norms even if it foresees a personal cost-is one of the most useful and fruitful paradigms; it allows to maintain a cooperation system within social groups. Alterations of this cognitive ability negatively impact the quality of life of the individual and social stability. Social neuroscience has suggested association between impulsive behaviors and altruistic punishment. CERC 006 Neuroimaging research aimed at exploring functional networks and intrinsic functional connectivity went in this direction. To date, little is known about these issues in neurodegenerative diseases such as PD.
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