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The effect involving HCV removal upon hyperglycemia, blood insulin resistance, cytokine generation, as well as insulin receptor substrate-1 and a couple of expression inside sufferers together with HCV contamination.
in English, Russian ЦЕЛЬ ИССЛЕДОВАНИЯ Оценить возможности и результаты мини-инвазивной адреналэктомии у детей, а также сравнить полученные данные с общемировой статистикой. МЕТОДЫ С 2003 по 2018 г. нами накоплен 15-летний опыт выполнения лапароскопических адреналэктомий у 65 пациентов в возрасте от 3 месяцев до 17 лет с различными заболеваниями адреналовых желез, направленных на хирургическое лечение врачами-эндокринологами. РЕЗУЛЬТАТЫ Среди всех удаленных образований 33.8% были выявлены случайно (инциденталомы). У 12% пациентов было двустороннее поражение. Максимальные размеры (12 см в диаметре) были у феохромоцитомы у пациента 9 лет. Интраоперационное кровотечение возникло у 2 пациентов. Всем пациентам выполнено эндовидеохирургическое удаление надпочечников с образованиями. ЗАКЛЮЧЕНИЕ Опыт лапароскопического удаления доброкачественных неоплазий надпочечников в рамках одного медицинского подразделения является значительным, а результаты сопоставимы с результатами других исследователей, как отечественных, так и зарубежных. Только тесное сотрудничество детских хирургов и врачей-эндокринологов является гарантом успешного и безопасного излечения таких больных. Пациенты с подозрением на злокачественный процесс должны получать лечение в онкологическом стационаре.Hyperthermia is a rapidly growing field in cancer therapy and many advances have been made in understanding and applying the mechanisms of hyperthermia. Secondary effects of hyperthermia have been increasingly recognized as important in therapeutic effects and multiple studies have started to elucidate their implications for treatment. Immune effects have especially been recognized as important in the efficacy of hyperthermia treatment of cancer. Both thermo-ablative and mild hyperthermia activate the immune system, but mild hyperthermia seems to be more effective at doing so. This may suggest that mild hyperthermia has some advantages over thermo-ablative hyperthermia and research into immune effects of mild hyperthermia should continue. This article is categorized under Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery. © 2020 Wiley Periodicals, Inc.BACKGROUND Local lateral recurrence (LLR) in rectal cancer is increasingly becoming a significant clinical issue. Preoperative neoadjuvant chemoradiotherapy (nCRT) and lateral lymph node dissection (LLND)-when each approach is separately executed-cannot cure lateral lymph node metastasis (LLNM). Here, we performed a meta-analysis to evaluate the efficacy of nCRT plus total mesorectal excision (TME) vs TME plus LLND after nCRT for rectal cancer. METHODS Standard databases (PubMed, Embase, MEDLINE, Cochrane Library, and Web of Science) were searched to identify all relevant studies comparing nCRT+TME and nCRT+TME+LLND. Data in the included studies were extracted, and intraoperative outcomes, postoperative complications, and oncological outcomes were evaluated. RESULTS Eight studies representing 1,896 patients (1,461 nCRT+TME vs 435 nCRT+TME+LLND) were included. We found that for patients with clinically suspected LLNM, the incidence of pathological LLNM was 27.8%, even after nCRT. LLND after nCRT was significantly associated with lower LLR (P = .02). Additional LLND yielded a longer operative time (P less then .01) and increased the risk of urinary dysfunction (P less then .01). Concerning other outcomes, no significant differences were identified between the two groups. CONCLUSION This is the first meta-analysis and systematic review of studies comparing nCRT+TME and nCRT+TME+LLND for rectal cancer patients. Although increasing operative time and the risk of urinary dysfunction (which might be ameliorated by minimally invasive procedures), the pooled results support the use of LLND after nCRT and TME for reducing LLR in patients with clinically suspected LLNM and provide another treatment option for high-risk patients. © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.A spaceflight has enormous influence on the health of space voyagers due to the combined effects of microgravity and cosmic radiation. Known effects of microgravity (μg) on cells are changes in differentiation and growth. Considering the commercialization of spaceflight, future space exploration, and long-term manned flights, research focusing on differentiation and growth of stem cells and cancer cells exposed to real (r-) and simulated (s-) μg is of high interest for regenerative medicine and cancer research. In this review, we focus on platforms to study r- and s-μg as well as the impact of μg on cancer stem cells in the field of gastrointestinal cancer, lung cancer, and osteosarcoma. Dulaglutide Moreover, we review the current knowledge of different types of stem cells exposed to μg conditions with regard to differentiation and engineering of cartilage, bone, vasculature, heart, skin, and liver constructs. © 2020 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.
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