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Infants between ages 6 and 11 months and children younger than 2 years had the lowest seropositivity rates being the age groups with the highest attack rates of measles during the epidemic of 2018. Efforts should be aimed at avoiding any delay in vaccination once a child reaches the age of 1 year and improving immunity levels in children aged 1-4 years.Objective To develop and validate a prediction model for identifying pregnant women at risk of developing pregnancy-induced hypertension (PIH) to guide treatment decision and classification of management. Methods This study retrospectively enrolled 907 consecutive pregnant women with de novo hypertension from the Antenatal Care Center of Henan Provincial People's Hospital between June 1, 2018 and May 31, 2019. The cohort was randomly divided into two subgroups the development cohort (n = 635) and validation cohort (n = 272). Univariate analysis and backward elimination of multivariate logistic regression analyses were utilized to identify predictive factors, and a nomogram was established. The performance was assessed using the area under the curve (AUC), the mean AUC of k-fold cross-validation, and calibration plots. Based on the classification and regression tree model, risk classification was performed. Results The score included five commonly available predictors body mass index, proteinuria, age, uric acid, and mean arterial pressure (BPAUM score). When applied to internal validation, the score revealed good discrimination with stratified fivefold cross-validation in the development cohort (AUC = 0.91) and validation cohort (AUC 0.89) at fixed 10% false-positive rates, and the calibration plots showed good calibration. The total score point was divided into three risk classifications low risk (0 - 179 points), medium risk (179 - 204 points), and high risk (>204 points). Conclusions This study established a prediction model for predicting PIH, which could be used in clinical decision-making to improve maternal health and birth outcomes.
Though human papillomavirus (HPV) vaccination is a safe and effective method of protecting against associated cancers, uptake rates remain low among adolescents. Few studies have examined how social media use contributes to HPV-related knowledge gaps among parents and caregivers.
To investigate the association between social media use and HPV-related awareness and knowledge with a focus on differences by gender and race/ethnicity among a nationally representative sample of adults with children in the household.
We used data from the Health Information National Trends (HINTS) Survey (2017-2019) (N=2,720). Multivariate logistic regressions were used to examine the association of social media use on HPV awareness and knowledge outcomes.
Compared to non-users, engaging in one, two, three, or four social media behaviors were associated with greater HPV awareness (aOR 2.09; 95%CI 1.18-3.70, aOR 2.49; 95%CI 1.40-4.42, aOR 2.64; 95%CI 1.15-6.05, and aOR 2.44; 95%CI 1.11-5.36, respectively). Increased social mulnerable populations.
Adolescents are the primary target population for human papillomavirus (HPV) vaccination. The objective of this study is to explore the acceptability of HPV vaccines and evaluate factors related to willingness to be vaccinated among Chinese adolescents.
A nation-wide survey was conducted across 14 schools in mainland China. The questionnaire consisted of questions relating to socio-demographic characteristics, knowledge of adolescent sexual health, cervical cancer, HPV and HPV-related disease, and students' willingness to be vaccinated.
-square tests and multivariable logistic regression were conducted in the data analysis.
A total of 4,062 students participated in this study. Among them, only 17.1% of students reported having heard of HPV vaccines; however, 67.3% were willing to receive the HPV vaccine. Multivariable regression analysis showed that students who were from rural areas, have received sexual health education, have heard of cervical cancer or HPV vaccine, have a positive attitude toward vaccination, reported they were at the risk of developing cervical cancer, and those who value their parents' and teachers' opinions were more willing to receive HPV vaccination.
Awareness about the HPV vaccine is low among Chinese adolescents. The factors that most related to willingness to vaccinate among Chinese adolescents were school location, education about vaccination, HPV, and HPV vaccines. Integrating health education on HPV vaccination into existing school-based sexual health curricula may be an effective way to increase HPV vaccination coverage in mainland China.
Awareness about the HPV vaccine is low among Chinese adolescents. The factors that most related to willingness to vaccinate among Chinese adolescents were school location, education about vaccination, HPV, and HPV vaccines. Integrating health education on HPV vaccination into existing school-based sexual health curricula may be an effective way to increase HPV vaccination coverage in mainland China.Rotavirus is the leading cause of severe dehydrating gastroenteritis and death due to diarrhea among children under 5, causing over 180,000 under-5 deaths annually. EN450 supplier Safe, effective rotavirus vaccines have been available for over a decade and are used in over 98 countries. In addition to the globally available, WHO-prequalified ROTARIX (GSK) and RotaTeq (Merck), several new rotavirus vaccines have attained national licensure - ROTAVAC (Bharat Biotech) and ROTASIIL (Serum Institute of India), licensed and manufactured in India and now WHO-prequalified, and Rotavin-M1 (PolyVac), licensed and manufactured in Vietnam. In this review, we summarize the available clinical trial and post-introduction evidence for these three new orally administered rotavirus vaccines. All three vaccines have demonstrated safety and efficacy against rotavirus diarrhea, although publicly available preclinical data are limited in some cases. This expanding product landscape presents a range of options to optimize immunization programs, and new presentations of each vaccine are currently under development.
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