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The protecting role of curcumin against harmful aftereffect of nonylphenol upon bone growth.
Statistical analyses were carried out by means of linear mixed-effect models. The results show that while both groups produce /ʃ/ with similar acoustic characteristics, between-group differences are found for /f/ and /s/. Furthermore, effects of consonant-vowel coarticulation are found for children with NH, and are absent for children with CIs. Effects of chronological age are only found for children with CIs (production in older children with CIs nearing that of children with NH). Our study shows that the development of fricative production of five- to 11-year-old children with CIs is affected by the children's hearing abilities and late access to auditory information. These limitations however do not prevent the children from eventually reaching a consistency similar to that of children with NH, as suggested by the fact that their production is still evolving during that age span. The results also show that the acquisition of coarticulation strategies can be impeded by degraded or delayed access to audio.We report on familial 5 epilepsy patients with autosomal dominant inheritance of a novel heterozygous NUS1 frameshift mutation. All patients had cerebellar ataxia and tremor. Three patients were diagnosed with childhood absence epilepsy, 1 patient with generalized epilepsy, and 1 patient with parkinsonism without epilepsy. Our cases and previously reported cases with deletions of chromosome 6q22 that include NUS1 share these common symptoms. In a cellular experiment, NUS1 mutation led to a substantial reduction of the protein level of NUS1. NUS1 mutation could contribute to epilepsy pathogenesis and also constitute a distinct syndromic entity with cerebellar ataxia and tremor.Objective Contrasting results are reported on the clinical course of acute diverticulitis (AD) in the geriatric population. The aim of this study is to compare the AD clinical outcomes between patients aged up to 80 years and those ≥80 years. Methods A total of 1139 patients were enrolled 276 patients aged ≥80 years were compared to a group of 863 patients aged less then 80 years. The primary outcome was to compare the overall mortality. Secondary outcomes included major complications, in-hospital length of stay (LOS), and need for surgical procedures. Results Patients ≥80 years with AD had different clinical presentation compared to younger patients they had less fever (21.4% vs. 35.2%; P less then 0.001) and abdominal pain (47.8% vs. 65.6%; P less then 0.001) rates, but a higher digestive tract bleeding (31.5% vs. 12.3%; p less then 0.001), and fatigue (12.7% vs. 7.1%; p = 0.004) rates. Median LOS, cumulative major complications and mortality rates were higher for patients ≥80 years. Multivariate analysis identified age, absence of abdominal pain, and dyspnea at presentation as independent predictors of intra hospital death or major complications. Conclusions Patients with AD and age ≥80 years have a higher mortality rate and cumulative major complications as compared younger patients. Invasive treatments were associated to a poor prognosis in this group.Objective This article introduces SCALPEL3 (Scalable Pipeline for Health Data), a scalable open-source framework for studies involving Large Observational Databases (LODs). It focuses on scalable medical concept extraction, easy interactive analysis, and helpers for data flow analysis to accelerate studies performed on LODs. Materials and methods Inspired from web analytics, SCALPEL3 relies on distributed computing, data denormalization and columnar storage. It was compared to the existing SAS-Oracle SNDS infrastructure by performing several queries on a dataset containing a three years-long history of healthcare claims of 13.7 million patients. Results and discussion SCALPEL3 horizontal scalability allows handling large tasks quicker than the existing infrastructure while it has comparable performance when using only a few executors. SCALPEL3 provides a sharp interactive control of data processing through legible code, which helps to build studies with full reproducibility, leading to improved maintainability and audit of studies performed on LODs. Conclusion SCALPEL3 makes studies based on SNDS much easier and more scalable than the existing framework [1]. It is now used at the agency collecting SNDS data, at the French Ministry of Health and soon at the National Health Data Hub in France [2].Background Guanxin V (GXV), a traditional herbal mixture, has been widely used in clinical practice for the treatment of coronary artery disease (CAD). This retrospective study was designed to assess the safety and effectiveness of GXV for CAD. Methods In our study, December 2006 to January 2009, 101 patients with CAD from Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine were enrolled, of whom 52 patients received GXV plus guideline-recommended medical therapy (GMT) (GXV group), 49 patients received GMT alone (GMT group). The general clinical information, traditional Chinese medicine syndrome score (TSS), the therapeutic effects, 6-minute walk test (6MWT), adverse events, echocardiography, and laboratory information were collected and analyzed pre-and post-treatment. Results We did not find differences in the information between the two groups before treatment. Patients in the GXV group had decreased TSS (P less then 0.0001) and increased therapeutic effects (P = 0.763) and 6MWT (P less then 0.0001) than those in the GMT group and there were no significant differences in safety between the two groups. Moreover, patients in the GXV group improved ejection fraction, cardiac output, and stroke volume (P = 0.2113, 0.0001, 0.0002, respectively), and dropped BNP (P = 0.3856) compared with those in the GMT group. Conclusions Superiority in the GXV group for patients with CAD was demonstrated over the GMT group for both the safety and effectiveness endpoints. This suggests that GXV is a potentially safe and effective treatment for CAD patients.Being a critical neurodevelopmental stage that is affected by social conditions, the period of adolescence was chosen as the age of examining possible modification of alcohol neurobehavioral effects by overcrowding. Adolescent male rats (postnatal day 35±1) were subjected to overcrowding and/or injected with ethanol, 2 g/kg, 20% w/v, (i.p.) for one week. 24 h after the last dose, motor, exploratory behavior, sociability and fear responses were assessed using open field, social interaction and defensive probe burying tests, respectively. Wet brain tissue nitric oxide and reduced glutathione contents as well as monoamine levels, namely dopamine, norepinephrine and serotonin, in addition to 5-HIAA were estimated. Overcrowding increased social play and freezing time. Alcohol administration under overcrowding condition impaired sociability and interfered with active fear response. Alcohol in normal or in under overcrowding condition, impaired motor and exploratory behavior and increased anxiety. AGI-24512 These results indicate that concomitant exposure of male adolescent rats to overcrowding and alcohol induced adverse behavioral changes.
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