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Joint preservation strategies in young, active patients are a challenge, particularly in those with combined cartilage and meniscal deficiency. Concomitant malalignment and/or ligamentous insufficiency are not uncommon and further add to the complex nature of these patients. Saracatinib concentration In patients who require surgery, a complete treatment strategy must be developed and implemented because unaddressed pathology typically leads to poor outcomes over time. In addition to reconstructive procedures, biologic therapies both as nonsurgical treatments and surgical augments offer promise, but their indications and place in orthopaedics continue to evolve. A comprehensive approach to this difficult patient population, including understanding all underlying pathologies, the natural history of each condition, and the appropriate treatment for each pathology, is necessary for successful joint preservation treatment in the young and active population.Meniscal pathology is one of the most common structural knee issues seen and managed by the orthopaedic surgeon. An ever-evolving armamentarium of management options exists that are geared toward the elimination of symptoms and restoration of normal knee function. A common theme among these management options is to preserve meniscal tissue whenever possible through repair or minimization of meniscal excision, as the literature has shown that the loss of meniscal tissue can significantly alter the distribution of forces and contact stresses on knee articular cartilage, thus predisposing the joint to degenerative osteoarthritis. In the setting of meniscal injuries or insufficiency, various advances in repair techniques, use of meniscal allografts, and use of biologic adjuvants have been reported to help preserve and/or attempt to restore the native kinematic properties of the knee. It is important to explore meniscal function, its associated pathologies, and currently available treatment options that are supported by short-term and long-term clinical data.Chondral lesions of the patellofemoral joint are common, and when symptomatic they can be difficult to manage. Not only are there various degrees of injury with multiple etiologies, but patellofemoral anatomy is complex and the patient's lower extremity alignment may contribute to the pathology. Treatment depends on the location, size, and depth of the lesion and may require realignment or concomitant stabilizing procedures. Tibial tubercle osteotomy can be performed in isolation or combined with various cartilage-based treatments, including marrow stimulation techniques, autologous chondrocyte implantation, osteochondral autograft, and osteochondral allograft. End-stage lesions, failed primary patellofemoral cartilage restoration with diffuse involvement, or isolated primary patellofemoral arthritis may be amenable to treatment with patellofemoral arthroplasty. Recent investigations in properly indicated patients using advanced techniques have shown that management of patellofemoral cartilage disease is now more effective and predictable than in the past.Patellofemoral instability is a common pathology especially in the adolescent female population.1,2 Prompt diagnosis and management is critical to prevent future episodes of instability as well as to reduce the risk of cartilaginous injury to the patellofemoral articular surface. Initial management of a first-time patellar dislocation has historically been nonsurgical; however, the presence of intra-articular loose bodies or osseocartilaginous injury may require surgical intervention.3,4 More recent evidence has shown patients with specific risk factors such as skeletal immaturity, an incompetent medial soft-tissue sleeve, family history of patellar dislocation, elevated tibial tubercle to trochlear groove distance, patella alta, and high-grade trochlear dysplasia experience high rates of re-dislocation after initial nonsurgical management.4-9 Based on this, the provider needs to consider these risk factors and the possibility of initial surgical management in these patient populations following a first-time patellar dislocation. Surgical options for management of patellar instability and cartilaginous injury include medial patellofemoral ligament repair, medial patellofemoral ligament reconstruction, tibial tubercle osteotomy, and various cartilaginous repair/restoration procedures. It is important to be knowledgeable about the clinical and anatomic/radiographic risk factors associated with patients presenting with patellar instability, the algorithm for treatment, the indications and surgical technique for medial patellofemoral ligament reconstruction and tibial tubercle osteotomy, and management of cartilaginous injury to the patellofemoral joint.Given that sports medicine covers a broad spectrum of orthopaedic injuries, the team physician is often required to face challenging decisions when treating injured athletes. Injuries of the upper and lower extremities can lead to clinical dilemmas for the team physician, who needs to ensure appropriate treatment and interventions to prevent subsequent injuries. The athlete's personal goals and athletic career must also be respected throughout this process. It is important to discuss the most common athletic injuries that pose clinical dilemmas for the sports physician and useful tips to address them based on the existing evidence.The number of revision total knee arthroplasties (TKAs) is greatly increasing. It is important to know how to approach the painful and malfunctioning TKA to determine the etiology and establish surgical plan, and also how to perform a basic revision TKA. Following the conclusion of this chapter, the reader should feel familiar with the full spectrum of treatment for patients who may be indicated for revision TKA.Unicompartmental knee arthroplasty and patellofemoral arthroplasty were pioneered in the 1970s but abandoned by most in favor of total knee arthroplasty because of inconsistent early outcomes. Advancements in implant design, instrumentation, indications, and surgical techniques have enhanced results and led to a resurgence in both unicompartmental knee arthroplasty and patellofemoral arthroplasty for appropriate candidates. In appropriately selected patients, current implants and techniques provide surgeons the resources to carry out a surgical procedure that is simpler to perform and easier to recover from. Furthermore, unicompartmental knee arthroplasty is associated with fewer postoperative complications and lower mortality and is equal to or better than total knee arthroplasty.
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