Notes

Medicinal characterisation with the CB1 receptor antagonist task involving cannabidiol from the rat vas deferens bioassay.
AIMS The present study aimed to reveal microbial relationship between shrimp intestine and ambient in higher place shrimp ponds from the aspects of composition and function. METHODS AND RESULTS Metagenome and 16S rRNA gene sequencing were used to compare microbial compositions and functions of water, effluent and shrimp intestine in higher place Litopenaeus vannamei ponds. SGI-1776 order Although the three groups had similar dominant phyla, such as Proteobacteria, Bacteroidetes and Tenericutes, their bacterial compositions at the genus level were obviously different. Compared to effluent and intestine, the relative abundance of Vibrio as common opportunistic pathogen for shrimp was significantly higher in water. However, cluster analysis showed that intestinal microbial composition was more similar to that of effluent than water. Metagenomic data showed that the predominant microbial functions in the three groups were mostly related to energy production and biosynthesis, while carbohydrate metabolism was relatively enriched in intestinal microbiota. More importantly, Proteobacteria played a critical role in carbon metabolism and biosynthesis of amino acids in the three habitats, and Vibrio had the most functions related to bacterial virulence and infection. CONCLUSIONS Shrimp intestinal microbiota had a close correlation with the ambient microbiota in both structure and function. As the most dominant phylum, Proteobacteria was very important for microbiota communication and nutrient cycling in higher place shrimp ponds. Moreover, due to the pathogenicity, it was necessary to monitor the abundant changes of Vibrio in water to decrease the risk of shrimp disease outbreaks. SIGNIFICANCE AND IMPACT OF THE STUDY These above results may be helpful to comprehensively understand the characteristics and functions of microbiota in higher place shrimp ponds, thereby providing basic information for developing the management strategies of entire microbiota to sustain shrimp health. © 2020 The Society for Applied Microbiology.BACKGROUND We identified variation in delivery of guideline recommended care at our institution, and undertook a project to design a HF model of care. AIM To maximize time patients with HF spend well in the community by delivering best practice guidelines to reduce variation in care improving overall outcomes. METHOD This quality improvement project focused on reducing variation in process measures of care. The HF model of care included electronic HF care bundles, a patient education pack with staff training on delivering HF patient education, referral of all HF patients to the Hospital Admissions Risk Program for phone call within 72 h, and a nurse-pharmacist early follow-up clinic. Outcomes were assessed using interrupted time series analyses. RESULTS The pre-intervention group comprised 1585 patients, and post-intervention 1720 patients with a primary diagnosis of HF admitted under general cardiology and general medicine. Interrupted Time Series analysis indicated 30-day readmissions did not change in overall trend (-0.2% per month, p = 0.479) but with significant step-down of 7.8% (p = 0.018). For 90-day readmissions, a significant trend reduction over the time period was seen (-0.6% per month, p = 0.017) with a significant immediate step-down (-9.4%, p = 0.001). Emergency department re-presentations, in-patient mortality and length of stay did not change significantly. Improvements in process measures were seen at audit. CONCLUSION This model of care resulted in overall trends of reductions in 30 and 90 day readmissions, without increasing ED representations, mortality and length of stay. This model will be adapted to the electronic medical record at our institution. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Owing to the remarkable physicochemical properties such as hydrophobicity, conductivity, elasticity, and light weight, graphene-based materials have emerged as one of the most appealing carbon allotropes in materials science and chemical engineering. Unfortunately, pristine graphene materials lack functional groups for further modification, severely hindering their practical applications. To render graphene materials with special characters for different applications, graphene oxide or reduced graphene oxide has been functionalized with different organic agents and assembled together, via covalent binding and various noncovalent forces such as π-π interaction, electrostatic interaction, and hydrogen bonding. In this review, we briefly discuss the state-of-the-art synthetic strategies and properties of organic-functionalized graphene-based materials, and then, present the prospective applications of organic-functionalized graphene-based materials in sample preparation. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND Residual kidney function (RKF) has been associated with improved solute clearance and survival in hemodialysis (HD) patients. However, whether RKF impacts symptom burden in HD patients is unknown. AIMS To determine the prevalence of RKF in HD patients and to explore associations between higher levels of RKF with symptom burden, as well as clinical and biochemical parameters. METHODS This is a single centre, retrospective, observational study. RKF was assessed as urea clearance (KRU) by interdialytic urine collection. Symptom burden was measured using the palliative care outcome scale renal questionnaire. RESULTS 90 maintenance HD patients were recruited. 31.9% had KRU ≥1ml/min/1.73m2. Patients with KRU ≥1ml/min/1.73m2 reported fewer symptoms (5.3 ± 3.5 vs 7.7 ± 3.8) (p=0.011), including less shortness of breath (15% vs 55%) (p=0.0013) and vomiting (0% vs 30%) (p=0.0016). Higher RKF was associated with lower β2-microglobilin (p less then 0.0001), and lower serum potassium (p=0.02), but no difference in phosphate, hemoglobin, C-reactive protein or serum albumin. CONCLUSION Higher RKF was significantly associated with fewer symptoms, and lower serum β2-microglobilin and potassium, suggesting that strategies to preserve RKF may be beneficial. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
My Website: https://www.selleckchem.com/products/SGI-1776.html