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1.) Faktor Genetika
Faktor genetika akan mempengaruhi kecepatan pertumbuhan dan kematangan tulang, alat seksual, serta syaraf, sehingga merupakan modal dasar dalam mencapai hasil akhir proses tumbuh kembang, yaitu : perbedaan ras, etnis, atau bangasa, keluarga, umur, jenis kelamin, kelainan kromosom, pengaruh hormone.
2.) Faktor Lingkungan
Faktor lingkungan merupakan faktor yang memegang peranan penting dalam menentukan tercapai dan tidaknya potensi yang sudah dimiliki. Yang termasuk faktor lingkungan yaitu lingkungan prenatal lingkungan kandungan), dan lingkungan postnatal (lingkungan setelah lahir).
3.) Lingkungan Prenatal (selama kehamilan) :
(1) Gizi, nutrisi ibu hamil akan mempengaruhi pertumbuhan janin, terutama selama trimester akan persalinan.
(2) Mekanisme, posisi janin yang abnormal dalam kandungan dapat menyebabkan kelainan kongenital.
(3) Toksin, zat kimia, radiasi.
(4) Kelainan endokrin.
(5) Infeksi TORCH atau penyakit menular seksual
(6) Kelainan imunologi
(7) Psikologi ibu
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