Notes

Innate popular features of precursor B-cell phenotype Burkitt the leukemia disease using IGH-MYC rearrangement.
For example, when cognitive and motor functions relied on cerebellar function simultaneously, the ataxia group's motor function was unaffected, in contrast to that of controls whose motor performance declined as a function of cognitive load. These findings indicated that the cerebellum is not critical for all forms of sequencing per se. Instead, it plays a fundamental role for sequencing within the implicit domain, whether functions are motor or cognitive. Moreover, individuals with cerebellar ataxia are generally able to compensate for cognitive sequencing when explicit strategies are available in order to preserve resources for motor function.In this paper, I offer a prolegomenon to the philosophy of harm reduction. I begin with an overview of the philosophical literature on both harm and harm reduction, and a brief summary of harm reduction scholarship outside of philosophy in order to make the case that philosophers have something to contribute to understanding harm reduction, and moreover that engagement with harm reduction would improve philosophical scholarship. I then proceed to survey and assess the nascent and still modest philosophy of harm reduction literature that has begun to emerge. I pay particular attention to two Canadian philosophers who have called for the expansion of harm reduction beyond the realm of so-called "vice" (that is, addiction, intoxicants and sex work). Finally, I sketch some of the most interesting and important philosophical issues that I think the philosophy of harm reduction must grapple with going forward.Small molecules derived from natural sources such as plants, fungi, bacteria, or synthetic materials have served as promising drug candidates for a long time. Unambiguous determination of chemical structures of these natural/synthetic molecules is a prerequisite for their development into new drugs. Despite the significant development of modern analytical tools it is still challenging to accomplish full structural assignment. In the last decades, computational chemistry methods using quantum mechanics and molecular mechanics theories followed by sophisticated statistical approaches have been rapidly developed. Such in silico platforms have widely and successfully been used to characterize and revise the structures of natural/synthetic products. In this review, we summarize contemporary computational approaches coupled with statistical methods for structure elucidation of small organic molecules. Among these approaches available, we opted for several relevant case studies in which the stereochemistry/structures of natural products were elucidated using these combinatorial methods.The C-terminally truncated Y145Stop variant of prion protein (PrP23-144) has been linked to a heritable prionopathy in humans and is also capable of triggering a transmissible prion disease in mice. PrP23-144 can be converted from soluble monomeric form to amyloid under physiological conditions, providing an in vitro model for investigating the molecular basis of amyloid strains and cross-seeding barriers. Here, we use magic-angle spinning solid-state NMR to establish the sequential backbone and sidechain 13C and 15N chemical shift assignments for amyloid fibrils formed by the A117V and M129V mutants of human PrP23-144, which in the context of full length PrP in vivo are among the specific residues associated with development of Gerstmann-Straüssler-Scheinker disease. The chemical shift data are utilized to identify amino acids comprising the rigid amyloid core regions and to predict the protein secondary structures for human PrP23-144 A117V and M129V fibrils.There were problems with the pdf display of this paper.
Primary care provider's (PCP) role in cancer care is expanding and may include supporting patients in their treatment decisions. However, the degree to which PCPs engage in this role for low-risk prostate cancer is unknown.

Characterize PCP perceptions regarding their role in low-risk prostate cancer treatment decision-making.

Cross-sectional, national survey.

For men with low-risk prostate cancer, PCP reports of (1) confidence in treatment decision-making (high vs. low); (2) intended participation in key aspects of active surveillance treatment decision-making (more vs. less).

A total of 347 from 741 eligible PCPs responded (adjusted response rate 56%). Half of respondent PCPs (50.3%) reported high confidence about engaging in low-risk prostate cancer treatment decision-making. The odds of PCPs reporting high confidence were greater among those in solo practice (vs working with > 1 PCP) (OR 2.18; 95% CI 1.14-4.17) and with higher volume of prostate cancer patients (> 15 vs. RO5126766 6-10 in past year)majority of PCPs were confident about engaging with patients in low-risk prostate cancer treatment decision-making, though their intended participation varied widely across four key aspects of active surveillance care. With active surveillance being considered for other low-risk cancers (such as breast and thyroid), understanding factors influencing PCP involvement will be instrumental to supporting team-based cancer care.The paper has a dual focus. One, is to use India as a case study to reflect upon the political, economic and socio-cultural structures of the country and how they shape the particular vulnerabilities in the society which have been aggravated in the COVID19 crisis-scape. Stories about Indian democracy, Casteism and Untouchability, Hindutva and Islamophobia emerging from the pandemic scenario have been extended to show global parallels. Stories of cultural resourcefulness and examples of people's power in the Indian context have also been represented to provide a formative assessment of how India is faring in the pandemic crisis. Two, it gathers emergent questions about human and social life which are being re-emphasized and created by the pandemic for Psychology to focus on. It makes use of Indian psychological concepts to re-envision self-other relationships in Post Coronial world. It makes a plea for strengthening the critical-cultural approach in 'Post-Coronial' Psychology.This article aims to establish, in the light of Semiotic-Cultural Constructivism in Psychology, a contribution to the research of creative processes through a reflection on the emergence of the new in the relationship between self-other-world. It is intended to advance in the classic approaches to creativity, by focusing on the unusual and ambiguous, affective-singularizing and, simultaneously, everyday-cultural face of the perspective of the possible and the new in the course of human action. In this way, the article focuses on fiction as a psychic reality that participates in the intersubjective field inherent to creative dynamics, as well as addresses affectivity in the Boeschian grammar from the place of the ambivalence and the dynamics between myths and fantasms in the forms of meaning construction in the face of disturbing experiences and uncertainty about the future. As an interpretive exercise, this text discusses a comic strip by a pair of elementary school students about a character who studies in a school where nothing was prohibited.
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