Notes

Modified VMAT Programs pertaining to In the area Innovative Situated Non-Small Cell Lung Cancer (NSCLC).
no association between IFIS and preoperative PD.
To compare the differences and consistency of IOL-Master 700 biometers applying swept optical coherence tomography with the conventional IOL-Master 500 applying partial coherence interference in terms of the ocular biological parameters in adolescents with ametropia.

A total of 110 adolescents (110 eyes) with ametropia were collected, including 55 males and 55 females; age 10.69±2.81y. VBIT-12 mw Ocular biological measurements were taken by IOL-Master 700 and IOL-Master 500 respectively to obtain biological parameters including axial length (AL), mean corneal anterior surface keratometry (K
), anterior chamber depth (ACD), and horizontal corneal diameter (WTW). Paired
-test was used to compare the differences between the two instruments. The intra-group correlation coefficient (ICC) and the Bland-Altman analysis were used to evaluate the consistency of parameter measurements between the two instruments for the four biological parameters.

Statistical analysis showed that there was no significant difference in thnstrument IOL-Master 700 makes no difference with IOL-Master 500 in the measurement of Km. There are some differences in the values of AL, ACD, and WTW. However, the two instruments show good consistency in these four biological measurements. The measured values of Km are interchangeable between the instruments. These two types of biometrics can be used as mutual reference in consideration of that the differences in AL, ACD, and WTW measurements are not sufficient to produce clinically meaningful differences.
To predict postoperative intraocular lens (IOL) position using the Sirius anterior segment analysis system and investigate the effect of lens position and IOL type on postoperative refraction.

A total of 97 patients (102 eyes) were enrolled in the final analysis. An anterior segment biometry measurement was performed preoperatively with Sirius and Lenstar. The results of predicted lens position (PLP) and IOL power were automatically calculated by the software used by the instruments. Effective lens position (ELP) was measured manually using Sirius 3mo postoperatively. Pearson's correlation analysis and linear regression analysis were used to determine the correlation of lens position to other parameters.

PLP and ELP were positively correlated to axial length (AL;
=0.42,
<0.0001 and
=0.49,
<0.0001, respectively). There was a weak correlation between the peLP (ELP-PLP) and the prediction error of spherical refraction (peSR;
=0.34,
<0.0001). The peLP of Softec HD IOL differed statistically from those of both the TECNIS ZCB00 and Sensor AR40E IOLs. Multiple linear regression was used to obtain the prediction formula ELP=0.66+0.63×[aqueous depth (AQD)+0.6LT] (
=0.61,
<0.0001), and a new variable (AQD+0.6 LT) was found to have the strongest correlation with ELP.

The Sirius anterior segment analysis system is helpful to predict ELP, which reduces postoperative refraction error.
The Sirius anterior segment analysis system is helpful to predict ELP, which reduces postoperative refraction error.
To evaluate the differences in corneal biological parameters between transepithelial and epithelium-off corneal cross-linking in keratoconus.

In our prospective clinical trial, 40 patients (60 eyes) with progressive keratoconus were randomized to undergo corneal cross-linking with transepithelial (TE group,
=30) or epithelium-off (EO group,
=30) keratoconus. Examinations comprised topography, corneal biomechanical analysis and specular microscopy at 6mo postoperatively.

The keratometer values were not significantly different between the TE and EO corneal cross-linked groups in different periods (each
>0.05). The corneal thickness of the EO group was greater than that of the TE group at 1wk after the operation (each
<0.05). Regarding corneal biomechanical responses, the EO group showed a longer second applanation length than TE group (
=0.003). Regarding the corneal endothelial function, standard deviation of the endothelial cell size, and coefficient of variation in the cell area, the values of EO group were larger than those of TE group at 1wk (
=0.011, 0.026), and the percentage of hexagonal cells in EO group was lower than that in TE group at 1 and 6mo (
=0.018, 0.019).

Epithelium-off corneal cross-linking may strengthen corneal biomechanics better than TE procedure can. However, the TE procedure with a lower ultraviolet-A irradiation intensity would be safer for corneal endothelial function.
Epithelium-off corneal cross-linking may strengthen corneal biomechanics better than TE procedure can. However, the TE procedure with a lower ultraviolet-A irradiation intensity would be safer for corneal endothelial function.
To explore whether the retinal neovascularization (NV) in a genetic mutant mice model could be ameliorated in an inherited retinitis pigmentosa (RP) mouse, which would help to elucidate the possible mechanism and prevention of retinal NV diseases in clinic.

The

mice, the genetic mutant mouse model of retinal NV caused by the homozygous mutation of
gene, with the
mice, the inherited RP mouse caused by homozygous mutation of
gene were bred. Intercrossing of the above two mice led to the birth of the F1 hybrids, further inbreeding of which gave birth to the F2 offspring. The ocular genotypes and phenotypes of the mice from all generations were examined, with the F2 offspring grouped according to the genotypes.

The
mice exhibited the RP phenotype of outer retinal degeneration and loss of retinal function. The

mice exhibited the phenotype of retinal NV obviously shown by the fundus fluorescein angiography. The F1 hydrides, with the heterozygote genotype, exhibited no phenotypes of RP or retinal NV. The F2 offspring with homozygous genotypes were grouped into four subgroups. They were the F2-I mice with the wild-type
and
genes (
-
), which had normal ocular phenotypes; the F2-II mice with homozygous mutant
gene (
-
), which exhibited the retinal NV phenotype; the F2-III mice with homozygous mutant
gene (
-
), which exhibited the RP phenotype. Specifically, the F2-IV mice with homozygous mutant
and
gene (
-
) showed only the RP phenotype, without the signs of retinal NV.

The retinal NV can be inhibited by the RP phenotype, which implies the role of a hyperoxic state in treating retinal NV diseases.
The retinal NV can be inhibited by the RP phenotype, which implies the role of a hyperoxic state in treating retinal NV diseases.
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