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2 g·d of BA or interruption of supplementation. Data were analyzed using generalized estimated equations with a priori 0.05 level of significance. The placebo group and interruption group presented a lower power (7.28 ± 0.66 and 7.71 ± 0.42 W·kg vs. 8.04 ± 0.84 and 9.25 ± 1.18 W·kg, respectively; p 0.05). The placebo group also presented higher percentage of fatigue (44.5% ± 12.3 and 44.8% ± 7.7 vs. 37.6 ± 7.2%; p = 0.021) and higher subjective perception of exertion (8.92 ± 0.90 vs. 8.00 ± 1.60; p = 0.028). Therefore, the maintenance dose of 1.2 g·d BA was effective in maintaining performance, whereas a reduction in performance was observed after supplementation interruption.Chaouachi, A, Ben Othman, A, Chaouachi, M, Hechmi, A, Farthing, JP, Granacher, U, and Behm, DG. Comparison of cross-education and global training effects in adults and youth after unilateral strength training. J Strength Cond Res XX(X) 000-000, 2020-Youth strength training research examining contralateral, homologous (cross-education), and heterologous (global training) effects after unilateral training have provided mixed results and the relationship to adults has not been compared. The objective was to compare adult and youth cross-education and global training effects on dominant and nondominant limb testing. Initially, 15 men and 15 prepubertal boys volunteered for each unilateral chest press (CP), handgrip training, and control groups (n = 89). Individuals trained their dominant limb 3 times per week for 8 weeks and had their dominant and nondominant limbs tested for CP and leg press 1 repetition maximum (1RM), handgrip, knee extension and flexion, and elbow extension and flexion maximum voluntary isometric contractions (MVICs). Adult CP training gains were significantly greater than youth with lower-body testing (p = 0.002-0.06), whereas youth CP training gains exceeded adults with upper-body tests (p = 0.03-0.07). Training specificity was evident with greater CP 1RM increases with CP vs. handgrip training for both youth (p less then 0.0001) and adults (p less then 0.0001). Handgrip training elicited greater gains in handgrip MVICs compared with other strength tests (p less then 0.0001). In conclusion, only contralateral CP 1RM showed a training advantage for unilateral CP over unilateral handgrip training. Adults showed greater gains with lower-body testing, whereas youth showed greater gains with upper-body testing.Morris, CE, Arnett, SW, and Winchester, LJ. Comparing physical fitness in career vs. volunteer firefighters. J Strength Cond Res XX(X) 000-000, 2020-The purpose of this study was to assess the potential similarities and differences in health and physical fitness profiles between career firefighters (CFF) and volunteer firefighters (VFF). The research protocol consisted of a health and physical fitness assessment, testing the 5 components of health-related fitness using previously published and accepted protocols. The subject population consisted of a total of 138 firefighters, including 119 CFF and 19 VFF. Statistical significance was defined as a p level less than 0.05. An independent t test showed evidence of CFF having a significantly higher value/score for the following variables height (p = 0.034), V[Combining Dot Above]O2max (p = 0.006), push-ups completed (p = 0.024), and plank time (p less then 0.001). Volunteer firefighters had a significantly higher value for the following variables fat mass (p = 0.002), body fat percentage (p less then 0.001), and absolute grip strength (p = 0.029). There were no significant differences between groups for the following variables age (p = 0.299), body mass (p = 0.166), fat-free mass (p = 0.281), body mass index (p = 0.057), flexibility (p = 0.106), or relative grip strength (p = 0.887). With regard to physical fitness testing, the VFF had a significantly worse fitness profile across a number of variables than the CFF. Practical applications Despite the financial and commitment status of volunteer firefighting departments, their members perform an equally dangerous and important job as do firefighters of professional/career firefighting departments, and more attention should be directed toward developing the fitness and performance of these firefighters.
This article reviews literature on the use of optical coherence tomography (OCT) in otology and provides the reader with a timely update on its current clinical and research applications. The discussion focuses on the principles of OCT, the use of the technology for the diagnosis of middle ear disease and for the delineation of in-vivo cochlear microarchitecture and function.
Recent advances in OCT include the measurement of structural and vibratory properties of the tympanic membrane, ossicles and inner ear in healthy and diseased states. click here Accurate, noninvasive diagnosis of middle ear disease, such as otosclerosis and acute otitis media using OCT, has been validated in clinical studies, whereas inner ear OCT imaging remains at the preclinical stage. The development of recent microscopic, otoscopic and endoscopic systems to address clinical and research problems is reviewed.
OCT is a real-time, noninvasive, nonionizing, point-of-care imaging modality capable of imaging ear structures in vivo. Although current clinical systems are mainly focused on middle ear imaging, OCT has also been shown to have the ability to identify inner ear disease, an exciting possibility that will become increasingly relevant with the advent of targeted inner ear therapies.
OCT is a real-time, noninvasive, nonionizing, point-of-care imaging modality capable of imaging ear structures in vivo. Although current clinical systems are mainly focused on middle ear imaging, OCT has also been shown to have the ability to identify inner ear disease, an exciting possibility that will become increasingly relevant with the advent of targeted inner ear therapies.
To review the principles of oncolytic virotherapy and summarize the recent preliminary evidence on the efficacy of oncolytic virotherapy for cholesteatoma (CHST) treatment in vitro in human CHST cells and in a gerbil CHST model.
The use of oncolytic virotherapy for nonmalignant lesions is innovative. In-vitro results showed that oncolytic herpes simplex virus 1 (oHSV) selectively targets and kills CHST cells. In a gerbil model of CHST, local oHSV injections were associated with a decrease in CHST volume and modulation of bony changes.
Surgical treatment options for CHST are limited by high morbidity and recidivism, emphasizing the need for developing treatment alternatives. Preliminary results support the potential therapeutic effect of oncolytic virotherapy on CHST, yet further research is needed to evaluate this novel approach.
Surgical treatment options for CHST are limited by high morbidity and recidivism, emphasizing the need for developing treatment alternatives. Preliminary results support the potential therapeutic effect of oncolytic virotherapy on CHST, yet further research is needed to evaluate this novel approach.
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