Notes

Beegle: through materials mining in order to disease-gene breakthrough discovery.
1% of patients. Twenty percent presented with combined airway anomalies. The control group consisted of 150 children (matched for age and sex) without significant underlying disease. The most common presentations were chronic cough and/or noisy breathing (29%), persistent radiographic abnormalities (20%), and suspicion of aspiration of a foreign body (15%). In the majority of controls (68%), no airway anomaly was found. Other findings were malacia (22%), tracheal bronchus (1%), and subglottic stenosis (1%). A combined anomaly was found in 5%. CONCLUSION Congenital airway anomalies were seen in 71% of patients with DS, compared with 32% of controls. Combined anomalies are more frequent in DS. Complete lower airway endoscopy is recommended in patients with DS as it may influence therapeutic decision-making. © 2020 Wiley Periodicals, Inc.Biochemistry is about structure and function, but it is also about data and this is where computers come in. From my time as a graduate student and post doc, whenever I encountered data I thought, "I can work this up by hand, but I think a computer could do a better job." Since that time, I have been working at the interface of biochemistry and computers, by attracting talented students and collaborating with colleagues with complementary skills. This has resulted in several exciting projects a simulation of 2D electrophoresis and tandem mass spectrometry, the human visualization project, and two different programs that enable biochemists to search protein structures for enzyme active sites ProMOL (promol.org) and Moltimate (moltimate.appspot.com). The human side of software development for education involved finding the right students and colleagues, communicating effectively across disciplines, building and managing effective teams and the importance of serendipity throughout the process. © 2020 International Union of Biochemistry and Molecular Biology.BACKGROUND Elevated oxidative stress plays a significant role in pathophysiology of keratoconus (KC). Polymorphisms of the antioxidant enzymes as CAT and GPX-1 might alter their antioxidant enzyme capacities leading to increase in the oxidative damage induced KC. AIM To analyze the impact of CAT rs7943316 A/T and GPX-1 rs1050450 C/T single nucleotide polymorphisms (SNPs) on the risk and severity of KC among a group of Egyptian population. SUBJECT & METHODS CAT rs7943316 and GPX-1 rs1050450 SNPs were examined using polymerase chain reaction-restriction fragment length polymorphism in 100 control subjects and 150 KC patients [50 patients (KC stages 1&2), 50 patients (KC stage 3) and 50 patients (KC stage 4)]. RESULTS Patients with TT genotype of CAT rs7943316 were at high risk of developing KC. T allele of GPX-1 rs1050450 was significantly associated with KC risk (P ˂0.001). The frequency of CAT TT genotype and T allele was significantly higher among severe stages of KC compared to mild and moderate stages. GPX-1 T allele frequency was significantly higher among severe stages of KC compared to mild and moderate stages. A very significant decrease in the antioxidant enzyme activities was observed in association with these SNPs. Age of the patients, CAT and GPX-1 SNPs as well as their enzyme activities were independent predictors of KC severity. CONCLUSION Our study suggests that CAT (rs7943316) and GPX-1 (rs1050450) SNPs act as independent predictors for different grades of KC and that these SNPs might have a role in the pathogenesis of the disease. This article is protected by copyright. All rights reserved.Herein, we disclose the first gold-catalyzed 1,2-diarylation of alkenes by adopting the interplay of ligand-enabled Au(I)/Au(III) catalysis with idiosyncratic pi-activation mode of gold complexes. Selleckchem Pralsetinib Unlike the classical migratory insertion based approach to 1,2-diarylation, the present approach not only circumvents the formation of direct Ar-Arꞌ coupling and Heck-type side products but more intriguingly furnishes reactivities and selectivities complementary to that of previously known metal catalysis (Pd, Ni or Cu). Detailed investigation was carried out to underpin the mechanistic scenario; which revealed oxidative addition of aryl iodides to Au(I) complex to be the rate limiting step owing to non-innocent nature of aryl alkene. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Herein, an environmentally friendly electrochemical approach is reported that takes advantage of the captodative effect and delocalization effect to generate nitrogen-centered radicals (NCRs). By changing the reaction parameters of the electrode material and feedstock solubility, dearomatization enabled a selective dehydrogenative C-N versus N-N bond formation reaction. Hence, pyrido[1,2-a]benzimidazole and tetraarylhydrazine frameworks were prepared via a sustainable transition-metal- and exogenous oxidant-free strategy with broad generality. Bioactivity assays demonstrated that pyrido[1,2-a]benzimidazoles displayed antimicrobial activity and cytotoxicity against human cancer cells. Compound 21 exhibited good photochemical properties with a large Stokes shift (approximately 130 nm) and was successfully applied to subcellular imaging. A preliminary mechanism investigation and density functional theory (DFT) calculations revealed the possible reaction pathway. Interestingly, the hydrazine products could be converted into pyrido[1,2-a]benzimidazole cores under a complementary acidic conditions, although the former was not the intermediate en route to the latter. Consequently, this divergent synthetic route will stimulate the NCRs development in electroorganic synthesis and related biomedical sciences. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.A vibrant and sustainable research environment is essential to establish a thriving PhD program. Organization for PhD Education in Health Sciences in European System, a European platform to promote best practices in PhD education in health sciences, published a guideline entitled "Best Practices for PhD Training." The guideline includes comprehensive recommendations and suggestions on different components of the PhD program, of which supervision is an essential one. A working supervisor-student relationship based on mutual respect, responsibility, and participation is essential for the success of a PhD thesis. Supervisors should be active researchers and receive training to develop their supervising skills. They serve as role models in academic life, both scientifically and ethically. The appointment of a co-supervisor, besides the principal one, is strongly encouraged not only to increase the efficiency in monitoring the student progression but also to defuse interpersonal conflicts. Institutional regulations should include the duties and responsibilities of the supervisor.
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