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FK506-binding protein 2 (FKBP13) prevent Bax-induced apoptosis in Saccharomyces cerevisiae (candida).
Introduction Although educational attainment and income are protective against tobacco use, Marginalization-related Diminished Returns (MDRs) theory posits that the protective effects of socioeconomic status (SES) indicators may be smaller for marginalized groups than mainstream social groups. We aimed to compare the effects of educational attainment and income on current smoking status of Chinese American and European American adults. Methods Data came from the National Health Interview Survey (NHIS - 2015). A total number of 28081 individuals entered our analysis. This included 420 Chinese Americans and 27661 European Americans. The independent variables were educational attainment (years of schooling) and annual income. The dependent variable was current established smoking status. Age, gender, region, and marital status were covariates. Ethnicity (Chinese American vs. European American) was the moderator. Results Overall, educational attainment and income were inversely associated with the odds of current established smoking. Ethnicity showed a significant interaction with income but not educational attainment. This finding suggested that the protective effect of income, but not educational attainment, on odds of current established smoking might be smaller for Chinese Americans than European Americans. Conclusions While educational attainment reduces the odds of current established smoking, high-income Chinese Americans remain at high risk of smoking due to a phenomenon called MDRs. In fact, high income is associated with greater smoking prevalence in Chinese Americans, rather than less. To reduce ethnic disparities in tobacco use, we need to go beyond SES inequalities by addressing structural causes of higher than expected risk of smoking in high SES ethnic minorities.Hypothesis This study aimed to examine the reliability and diagnostic discriminative accuracy of 5 different methods that quantity the craniocaudal humeral position with respect to the scapula on conventional radiographs. Methods In this retrospective, cross-sectional diagnostic study, 2 observers randomly assessed the conventional anteroposterior shoulder radiographs of 280 subjects with rotator cuff imaging for the (1) acromiohumeral (AH) interval, (2) upward migration index (UMI), (3) glenohumeral center-to-center measurement (GHCC), (4) glenohumeral arc measurement (GHa), and (5) scapular spine-humeral head center method (SHC). Reliability was assessed by means of relative consistency (intraclass correlation coefficient) and absolute consistency. Discriminative accuracy for detecting a rotator cuff tear was calculated. Results Relative consistency (intraclass correlation coefficient) for the AH interval, UMI, GHCC, GHa, and SHC was 0.961, 0.913, 0.806, 0.924, and 0.726, respectively. The AH interval had the highest absolute consistency with a random residual measurement error of 0.58 mm compared with 1.0-3.2 mm for the other measurements. The discriminative accuracy of the AH interval did not significantly differ from that of the UMI (-0.010; 95% confidence interval [CI], -0.042 to 0.022; P = .545) but was significantly better than that of the GHCC (0.112; 95% CI, 0.043-0.181; P = .001), GHa (0.074; 95% CI, 0.009-0.139; P = .027), and SHC (0.178; 95% CI, 0.100-0.256; P less then .001). Conclusion Assessment of the craniocaudal humeral position is performed with good to excellent intraobserver and interobserver reliability. The discriminative accuracy for detecting a rotator cuff tear on a single radiograph was highest for the AH interval and UMI. We recommend using the AH interval or UMI as an indirect measure of the presence of a rotator cuff tear on conventional radiographs. selleck © 2019 The Authors.Background Reverse shoulder arthroplasty (RSA) is frequently performed in the revision setting as a salvage procedure. The purpose of this study was to report the clinical outcomes and complication, reoperation, and revision rates after revision RSA (RRSA) stratified according to the primary shoulder procedure undergoing revision. Methods Four databases (Embase, MEDLINE, SPORTDiscus, and Cochrane Controlled Trials Register) were searched for eligible studies published between January 1985 and September 2017. The primary outcomes of interest included pain, active range of motion, and functional outcome scores. Secondary outcomes included complication, reoperation, and revision rates. Results A total of 43 studies (1041 shoulder arthroplasties) met the inclusion criteria, with a mean follow-up period of 43.8 months (range, 31.1-57.2 months). Pain scores improved in all groups; however, none reached statistical significance. Range of motion improved in all groups, except for external rotation in the RSA category. RRSA demonstrated significant improvements in the Simple Shoulder Test score and Constant score (CS) in the group undergoing hemiarthroplasty (HA) for fracture, CS in the group undergoing HA for other indications, and CS in the group undergoing anatomic total shoulder arthroplasty. Pooled complication rates were highest in the failed RSA group (56.2%), followed by the group undergoing HA for other indications (27.7%), total shoulder arthroplasty group (23.6%), soft-tissue repair group (20.6%), open reduction and internal fixation group (19.0%), and group undergoing HA for fracture (13.6%). Conclusions Compared with other revision indications, RRSA for failed HA demonstrated the most favorable outcomes, whereas the highest complication and revision rates were observed in the RSA subgroup. This information is useful when establishing patient expectations regarding the risks, benefits, and complication and revision rates of RRSA. © 2019 The Author(s).Background Reverse shoulder arthroplasty (RSA) has gained popularity in the treatment of proximal humeral fractures (PHFs), especially in elderly patients. The purpose of this study was to investigate the use of RSA implants for acute PHFs and risk of revision, as well as risk factors for revision. Methods RSA implants for acute PHFs were identified from the Nordic Arthroplasty Register Association registry data from 2004 to 2016. Kaplan-Meier survival analysis was used to calculate implant survival. Cox multiple regression analysis was used to calculate the adjusted revision rate for sex, age, country of operation, and year of surgery. Results The study included 1523 RSA implants for PHFs (84% women; average age, 77 years; average follow-up time, 2.5 years). The 5-year cumulative implant survival rate was 97% (confidence limits, 95.5% and 98%). Revision was performed for 33 implants (2%). The most common reason for revision was instability, occurring in 11 cases (0.7%), followed by fracture, occurring in 6 (0.
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