Notes

PTB area as well as leucine zip pattern One particular (APPL1) prevents myocardial ischemia/hypoxia-reperfusion damage by means of inactivation associated with apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling walkway.
Delayed healing of diabetes-related foot ulcers (DRFUs) is associated with increased macrophage and matrix metalloproteinases (MMPs) at the wound site. Whether circulating monocyte phenotype and/or MMPs are altered in association with wound healing outcome is unknown, and was investigated in this study.

Blood was obtained from 21 participants with DRFU, at initial visit (V1), week-4 (V2), and week-8 (V3) for measurement of monocyte number (CD14
), phenotype (CD16, CD163) and chemokine receptors (CCRs) by flow cytometry, and circulating MMPs and TIMP-1 by ELISA.

Six wounds healed during the study. At V1, non-classical CD16
monocytes and MMP-3 were higher in healed vs unhealed (both p < 0.05). At V3, the increased %CD16
persisted and %CCR2
was decreased in healed, but no other monocyte markers nor MMP/TIMP differed between groups. Increased wound closure rate (WCR) at V3 correlated with increased %CD16
monocytes and decreased MMP-2 at V1 or V1 + V2. Receiver operating characteristic (ROC) curves yielded an area-under-the-curve of %CD16
at V1 of 0.78 to predict ulcer healing at V3.

These results indicate that circulating monocyte phenotype and MMPs alter as DRFUs heal. The relationship of %CD16
monocytes with WCR and ROC curve suggest a predictive role of %CD16
monocytes for ulcer healing.
These results indicate that circulating monocyte phenotype and MMPs alter as DRFUs heal. The relationship of %CD16++ monocytes with WCR and ROC curve suggest a predictive role of %CD16++ monocytes for ulcer healing.
The aim of this study was to evaluate the association of nut consumption and its various types with metabolic syndrome (MetS) risk and to investigate whether lifestyle factors (physical activity and smoking status) and socioeconomic status (education and occupation) modulate the association of nut consumption and the risk of MetS.

We prospectively studied 1915 participants of the Tehran Lipid and Glucose study, among whom 591 were diagnosed with MetS during 8.9 years of follow-up. Nut consumption and its various types were assessed using a validated semi-quantitative food frequency questionnaire. Multivariable adjusted Cox regression was used to estimate Hazard Ratios (HRs) for MetS events across tertiles of nut consumption and its various types. Regarding interaction between nut consumption and physical activity levels, education levels, and smoking status on the risk of MetS, using joint classification, the effect modification of lifestyle factors and socioeconomic status on the association between nut status resulted in reduction in the risk of MetS in participants consuming nuts≥median in both educated and not-educated group (HRs 0.81, CI 0.66-0.98 for the non-educated group and HRs 0.63, CI 0.47-0.84 for the educated group).

Incorporating nuts, especially walnuts, into dietary patterns reduced the risk of MetS, especially among individuals with more physical activity levels.
Incorporating nuts, especially walnuts, into dietary patterns reduced the risk of MetS, especially among individuals with more physical activity levels.
Severe acute COVID-19 has taken on pandemic proportions with growing interest in identification of prognostic factors for mortality. Standardized bioelectrical impedance (BI) phase angle (SPhA), which is PhA adjusted by age and sex, has been related to mortality in patients with several diseases but never investigated in COVID-19. Inflammation, a consequence of COVID-19 infection, affects fluid status (hydration) and can be identified with PhA. The aim of this study was to determine the predictive role of PhA on 90 days survival of adults with COVID-19.

We studied 127 consecutive patients diagnosed with COVID-19. BI measurements determined with a 50kHz phase-sensitive BI device, body composition parameters and laboratory markers were evaluated as predictors of mortality.

Non-surviving COVID-19 patients had significantly lower PhA and SPhA values (p<0.001) and increased hydration (p<0.001) compared to surviving patients. Patients in the lowest SPhA quartile had increased (p<0.001) mortality and findings suggest that the evaluation of body composition with single-frequency phase-sensitive BI measurements should be included in the routine clinical assessment of COVID-19 patients at hospital admission to identify patients at increased mortality risk.
Low PhA ( less then 3.95°), independent of age, sex, BMI, and comorbidities, is a significant predictor of mortality risk in COVID-19. These findings suggest that the evaluation of body composition with single-frequency phase-sensitive BI measurements should be included in the routine clinical assessment of COVID-19 patients at hospital admission to identify patients at increased mortality risk.
Today synbiotics are considered as immunomodulatory agents. The current systematic review and meta-analysis investigated the effect of synbiotics and probiotics on inflammatory and oxidative stress markers in autoimmune disease.

The English literature search was performed using PubMed, Scopus, Web of Science, and the Central Cochrane Library through March 2020. Random effects models and generic inverse variance methods were used to synthesize quantitative data by STATA
.

From a total of 623 entries identified via searches, ten RCTs (n=440; 216 as intervention, 224 as controls) were included. An additional eleven studies with same intervention and different markers were also explained systematically. The pooled effect size showed that Interleukin (IL)-6 (WMD=-7.79pg/ml; 95% CI=-13.81,-1.77, P=0.011), Tumor Necrosis Factor (TNF)-α (WMD=-1.05pg/ml; 95% CI=-2.01,-0.10, P=0.030), high sensitivity C-Reactive Protein (hs-CRP) (SMD=-0.58; 95% CI=-0.79,-0.37, P<0.001), Malondialdehyde (MDA) (SMD=-0.36; 95% Crkers; although, the number of trials was too small to powerful conclusion and further investigations may be needed.
In previous studies, it's recommended that the lymph node involvement should be evaluated with enough examined lymph nodes (eLNs) in the 8th American Joint Committee on Cancer (AJCC) staging system for pancreatic cancer. This study aims to put forward a rescue staging system for pancreatic ductal adenocarcinoma (PDAC) patients with inadequate eLNs after pancreatoduodenectomy (PD).

11,224 PDAC patients undergoing PD in The Surveillance, Epidemiology, and End Results (SEER) database were included. Another Ruijin Pancreatic Disease Center (RJPDC) database consisted of 821 patients was utilized for external validation.

The proportions of patients with eLNs≥15 were 44.7% and 32.8% in SEER and RJPDC database separately. The rescue staging system was put forward relying on LNR (HR=1.83, 95% CI 1.74-1.92, P<0.001) for N staging of eLNs<15 population and pLNs for the rest. The TNM modalities were also rearranged in the rescue system for better survival coordination. Sodium butyrate The C-index of rescue staging system was 0.
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