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Neurosteroid substitute remedy regarding catamenial epilepsy, postpartum depressive disorders and also neuroendocrine ailments in women.
P less then 0.01). CONCLUSIONS The combination of methazolamide and theophylline in the prescribed dosages is not recommended for use at high altitude as it appears to have no measurable effect on AMS and can impair aerobic performance. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Intentional weight loss can increase health risk in the long-term, despite short-term benefits, because human adipose tissue is widely contaminated with various lipophilic environmental contaminants, especially persistent organic pollutants (POPs). Recently, chronic exposure to low POPs has emerged as a new risk factor for common metabolic diseases and cardiovascular diseases. The amount of POPs released from adipocytes to the circulation increases during weight loss, thereby increasing POPs exposure of other critical organs. Possible harmful effects due to release of POPs during weight loss are opposite to those usually expected from losing weight. It is speculated that this tradeoff can explain recent puzzling findings on intensive weight loss. The presence of POPs in adipose tissue adds a challenge to weight management and an optimal strategy of weight management needs to consider both fat mass and dynamics of POPs. © 2020 WILEY Periodicals, Inc.BACKGROUND Engaging in meaningful activity is an important contributor to well-being in late life. This study aimed to develop a new measure of meaningful and enjoyable activities in people living with mild dementia. METHODS The study consisted of four phases 1) a review of measures of meaningful activity in older people; 2) interviews with people with dementia and their carers (n = 32), 3) expert opinion; and 4) feasibility testing in a pilot randomised controlled trial (n = 63). RESULTS The development process resulted in a 20-item questionnaire. The Meaningful and Enjoyable Activities Scale (MEAS) evidenced appropriate levels of internal consistency (α = 0.79). Higher scores correlated with higher functional independence (r = -.605, P  less then  .001), patient (r = .330, P = .010) and carer-rated patient quality of life (r = .505, P  less then  .001). Multiple regression analyses showed that functional independence made a significant independent contribution in predicting higher levels of meaningful activity (F[7,45] = 6.75, P  less then  .001, R2 = .512; β = -.444, P = .001). Confirmatory factor analysis indicated that a revised three-factor 9-item model provided good fit for the data (X2 = 22.74, P = 0.54, GFI = 0.93, RMSE = 0.00), with leisure-time physical activity, social engagement and mentally stimulating activities as the key dimensions. CONCLUSION Our study provides support for the construct of meaningful activity in people with mild dementia. Although we find preliminary evidence that the MEAS has adequate psychometric properties, future large scale studies are required to test its validity further and responsiveness to change. This article is protected by copyright. All rights reserved.AIMS This systematic review aimed to identify school-based interventions for ensuring mental health and well-being of adolescents, synthesize existing interventions and summarize the quality of identified studies. DESIGN A systematic review, analysis and synthesis were performed. DATA SOURCES Search was performed in Cochrane Library, PsychARTICLES, Web of Science, CINAHL and Medline. REVIEW METHODS Literature search was performed in March 2019 using inclusion and exclusion criteria. PRISMA guidelines were followed. Identified records were reviewed by title, abstract and by the full text by two independent researchers. Three authors independently made a quality assessment of the included studies. Included studies were extracted and synthesized. A systematic review was registered in PROSPERO (CRD42019128919). read more RESULTS The initial search yielded 1199 articles. Of them, 57 articles were included in the final analysis and synthesis. Only four studies were assessed as high quality. Identified themes were mental healrepresents a list of effective school interventions for the promotion of adolescents' mental well-being. This article is protected by copyright. All rights reserved.Chemists and industrialists are continuously attempting to develop greener and more environmentally benign chemical processes to extract essential oils and bioactive metabolites of high purity, finding various applications in cosmetics, detergents, nutraceuticals and pharmaceuticals. An increase preference for natural products over synthetic ones has made supercritical fluid technology a primary alternative for the generation of high-value bioactive ingredients. This effective technique requires only moderate temperatures, eliminates clean-up steps, and avoids the use of harmful organic solvents. In this context, our study was focused on the chemical analysis of Calamintha nepeta subsp. nepeta aromatic extracts obtained with supercritical Carbon Dioxide (CO2 ). The effect of different operating conditions on the capacity of the lipophilic solvent to extract the targeted volatile components was also studied. The process was carried out at fairly low constant temperature of 40 °C, and with varying the pressure from 90 to 300 bar. The chemical composition of the extracts was analyzed by gas chromatography-mass spectroscopy (GC-MS). The results showed that the composition pattern, the concentrations of individual components and the quality of the extractable analytes, are affected by pressure increase. The extraction yields varied from 0.73 % to 1.21 % (wt.) at 90 bar and 300 bar, respectively. This article is protected by copyright. All rights reserved.OBJECTIVES Most persons living with dementia (PLWD) will develop neuropsychiatric symptoms (NPS) at some point. NPS are often clustered into subsyndromes with other, related symptoms, but the evidence supporting commonly-used clusters is insufficient. We reexamine behavioral clusters in community-dwelling PLWD, and identify associated risk factors and potential contributors. METHODS This study used baseline data from a longitudinal behavioral intervention study of 250 community-dwelling older adults with dementia and their caregivers. Using exploratory factor analysis (principal component analysis), the factor structure of NPS frequency scores of the Neuropsychiatric Inventory (NPI-C) was evaluated. Multiple linear regressions assessed the association of the derived behavioral clusters with caregiver burden, caregiver depression, and quality of life of the PLWD. RESULTS Principal component analysis yielded eight behavioral clusters (factors) 1 = Aggression/Rejection of Care, 2 = Apathy/Withdrawal, 3 = Restlessness/Agitation, 4 = Anxiety, 5 = Impulsivity/Disinhibition, 6 = Psychosis, 7 = Circadian Disturbance, and 8 = Depression.
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