Notes

Inherited tyrosinemia sort Ⅰ: newborn verification, treatment and diagnosis.
A systematic approach to patients with suspected idiopathic normal pressure hydrocephalus (iNPH) is essential to recognize the subset of patients who may benefit from ventriculoperitoneal shunt surgery (VPS). Quantitative biomechanical analysis of gait and balance (QBAGB) may help objectify the response to the cerebrospinal fluid tap test (CSF-TT) and VPS outcome after 3 months and support identification of candidates for VPS.

We retrospectively reviewed data from all patients with probable iNPH who 1) underwent clinico-radiological and neuropsychological assessments using validated scales (iNPH Scale and iNPH Radscale) at our centre in the period from January to December 2018; and 2) had completed QBAGB before CSF-TT ('baseline'), shortly after CSF-TT, and at three months after either VPS or conservative treatment.

At the time-points 'after CSF-TT' and '3 months', patients with iNPH and VPS (n = 11) significantly improved on the Kiefer Scale score, iNPH Scale total score and gait domain score, as well as in gait velocity and step length measured by QBAGB. In contrast, patients without surgery (n = 10) had unchanged iNPH Scale scores and motor performance throughout. Using data from all patients, we calculated cut-off levels for substantial improvements in gait velocity, step length, and the iNPH Scale domain gait score at the time-point 'after CSF-TT'.

QBAGB helps to objectify the response to CSF-TT to select candidates for VPS and corroborates clinico-radiological and neuropsychological data derived from validated scales. The QBAGB cut-off values for substantial improvement after CSF-TT need further elucidation in larger, preferably prospective studies.
QBAGB helps to objectify the response to CSF-TT to select candidates for VPS and corroborates clinico-radiological and neuropsychological data derived from validated scales. The QBAGB cut-off values for substantial improvement after CSF-TT need further elucidation in larger, preferably prospective studies.
Recent studies indicated that majority of stroke with undetermined etiology (SUE) showed strong overlap with cardioembolic stroke (CE). We intended to determine the efficacy of the mono antiplatelet (MA) therapy in both stroke types after receiving successful mechanical thrombectomy (MT) recanalization in the acute stage.

178 consecutive stroke patients who received MT treatment were retrospectively analyzed. selleck For CE and SUE type stroke patients, aspirin 100 mg or clopidogrel 75 mg was added immediate for those didn`t received IV-rtPA and after 24 h for those received IV-rtPA if symptomatic intracranial hemorrhage (sICH) was not found. MA treatment outcomes included recanalized artery patency, subsequent sICH and functional independence (mRS score 0-2) were compared between two stroke types.

75 CE and 50 SUE patients were included into final analysis. Target artery was confirmed 100 % patency in the CE group and 97.5 % in the SUE group at 7 days after recanalization. Hemorrhagic transformation after 24 h was found in 10 % patients in the SUE group and in 12 % patients in the CE group (P > 0.05). sICH was confirmed in 1 patient in the SUE group and in 2 patients in the CE group. At 90 days, 45.8 % in the SUE group and 46.5 % in the CE group of patients had achieved good outcomes (P = 1.00). However, accumulative death was higher in the CE group than in the SUE group (21 % vs. 15 %; P = 0.47).

For patients considered CE or SUE stroke types, mono antiplatelet therapy after good flow restoration by thrombectomy is safe and effective.
For patients considered CE or SUE stroke types, mono antiplatelet therapy after good flow restoration by thrombectomy is safe and effective.
MS is associated with structural and functional brain alterations leading to cognitive impairments across multiple domains including attention, memory, and speed of information processing. Here, we analyzed the white matter damage and topological organization of white matter tracts in specific brain regions responsible for cognition in MS.

Brain DTI, rs-fMRI, T1, T2, and T2-FLAIR were acquired for 22 MS subjects and 22 healthy controls. Automatic brain parcellation was performed on T1-weighted images. Skull-stripped T1-weighted intensity inverted images were co-registered to the b0 image. Diffusion-weighted images were processed to perform whole brain tractography. The rs-fMRI data were processed, and the connectivity matrixes were analyzed to identify significant differences in the network of nodes between the two groups using NBS analysis. In addition, diffusion entropy maps were produced from DTI data sets using in-house software.

MS subjects exhibited significantly reduced mean FA and entropy in 38 gnificant changes compared with healthy controls.The influence of persulfate assisted hydrothermal carbonization (HTC) (160 °C-220 °C) of spirulina and hydrochar properties was assessed. The elementary composition and proximate analysis of hydrochar were investigated on the carbonization degree and basic fuel properties, and the surface functional groups and morphological characteristics of hydrochar were analyzed as well as thermal stability. Results suggested that persulfate assisted process enhanced the carbonization degree of hydrochar by oxygen reduction (1.53%-2.74%) and increase of C ratio, and HHVs increased 0.81-1.39 MJ/kg at temperature above 180 °C. The -OH and CO on hydrochar surface were significantly reduced, and C-(C, H) and C-(O, N) were weakened by persulfate addition and more C-H peaks was formed. Additionally, the persulfate addition enhanced the thermal stability of hydrochar by lowing the maximum mass loss rate. The result suggested that HTC can be conducted with persulfate at lower temperature for hydrochar biofuel production.In this work, a simple and feasible approach for converting waste vinasse generated from the alcohol industries into high value-added activated carbon (AC) was proposed. The obtained AC possessed abundant micropores with micropore volume of 0.9613 cm3/g and ultrahigh specific surface areas (2015 m2/g), indicating prominent adsorption capacity. The adsorption ability of AC to cationic methylene blue (MB) was investigated systematically. The resultant AC exhibited superior adsorption ability to MB with a maximum amount of 2251 mg/g, derived from its excellent pore textural features and abundant surface O-containing functional groups. Moreover, AC showed excellent removal efficiency for treating industrial polyacrylonitrile wastewater with 99% removal within 60 min. Our results provide great inspirations in solid waste treatment and their high value-added transformation, meanwhile exploit a promising application of AC for practical wastewater purification.
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