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Sterile protective gloves are used to reduce the risk of infection for patients and clinicians in all healthcare settings. This is particularly important in operating theatres, where surgical site infection is a common and serious complication for perioperative patients. These gloves have traditionally been made from natural rubber latex and dusted with cornstarch powder. However, frequent use of latex gloves can lead to a hypersensitivity or allergy to latex. A latex allergy causes discomfort and inconvenience, and it may reduce productivity, impose significant financial burdens and even be life threatening. There has not been sufficient evidence to ban the clinical use of latex; however, in cases of suspected latex allergy, guidelines recommend the use of either latex-free gloves or powder-free, low-protein latex gloves. The use of these alternative gloves has typically been limited to cases of allergy, because they have previously been associated with reduced dexterity and durability compared with latex gloves. This article presents four case studies, in which health professionals in a perioperative setting compare the advantages and disadvantages of using traditional latex surgical gloves with those of latex-free gloves manufactured by Cardinal Health. The findings of these case studies suggest that these latex-free gloves are equal to latex gloves in terms of establishing asepsis and providing comfort and dexterity to the wearer, without presenting the risk of developing latex sensitivity and/or allergy.Dog walking has been widely promoted by the medical profession for its potential health benefits, especially among older individuals. However, this activity has a less well-recognized risk for notable cutaneous, osseous, and even neurologic trauma. We chronicle 5 cases of dog walking gone awry, leading to minor to massive cutaneous trauma, as a precaution for providers who heartily endorse this seemingly benign pastime.No funding supported the writing of this commentary. The author has nothing to disclose.A new catalyst system based on Co(OAc)2/bisoxazolinephosphine has been developed to catalyze the direct addition of terminal alkynes to isatins under base-free conditions. Chiral propargyl alcohols with an oxindole skeleton could be prepared in up to 99% yield and 99% ee with the help of the chiral tridentate ligand. A variety of functionalized aliphatic or aromatic alkynes and isatins were utilized in this method, and gram-scale synthesis could be achieved with 1 mol % catalyst.Cognitive impairment is common in persons with opioid use disorder and associated with poor treatment outcomes, including elevated risk for relapse. Much less is known about the underlying structure of these deficits and the possible presence of cognitive phenotypes. A total of 177 adults (average 42.2 years of age, 52.0% male, 65.5% Caucasian) enrolled in a methadone maintenance treatment program completed the NIH Toolbox as part of a larger project. Cluster analyses revealed a 2-cluster solution-persons with intact cognitive function in all domains (n = 93; Intact) and those with impairments on tests of attention and executive function (n = 83; Impaired). Follow-up analyses revealed that the Impaired group was slightly older, more likely to self-identify as a racial/ethnic minority, and less likely to report consuming alcohol four or more times per week. These findings suggest the existence of distinct cognitive profiles in persons with opioid use disorder and encourage further examination, particularly studies to examine the possible benefits of routine screening for cognitive impairment as part of substance use treatment.Absract This article presents a perspective on the value of yoga and mindfulness programming in carceral settings. The authors explore this topic through interviews with two formerly incarcerated people who participated in yoga programming while incarcerated and who went on to become yoga instructors themselves. Also examined are the potential effects of yoga programming for people who are incarcerated, for those working within carceral settings, and on carceral environments generally. We share recommendations for implementing yoga programming in carceral institutions and discuss policy implications. The stories of both interviewees reflect the value and potential positive effects of yoga programming within criminal justice settings and suggest the need for sustained programming and ongoing empirical evaluation.The male mouse is underrepresented in research of the urinary tract due to the difficulty of transurethral catheterization. As a result, there is a lack of analysis of gender differences in urinary tract research. Here, we present a novel catheter design and technique that enables urethral catheterization of male mice. Our catheterization technique uses the resistance met at the level of the external urinary sphincter and prostate to guide the retraction, positioning, and advancement of the catheter into the urinary bladder. We have shown that this method can be used to reproducibly catheterize 12 male mice with minimal urogenital trauma. This method will facilitate the expansion of research into sex differences in various genitourinary conditions that require transurethral catheterization of mice.Single-molecule force spectroscopy (SMFS) techniques allow for the measurements of several static and dynamic features of macromolecules of biological origin. In particular, the atomic force microscopy (AFM), used with a variable pulling rate, provides valuable information on the folding/unfolding dynamics of proteins. this website We propose here two different models able to describe the out-of-equilibrium statistical mechanics of a chain composed of bistable units. These latter represent the protein domains, which can be either folded or unfolded. Both models are based on the Langevin approach and their implementation allows for investigating the effect of the pulling rate and of the device intrinsic elasticity on the chain unfolding response. The theoretical results (both analytical and numerical) have been compared with experimental data concerning the unfolding of the titin and filamin proteins, eventually obtaining a good agreement over a large range of the pulling rates.
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