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Manufacturing regarding MgAl LDH@graphene oxide nanohybrids and their effect on the actual energy stability along with crystallization habits of polypropylene.
Bei etwa 40 % der Patienten kommt es zu Rezidiven der Beschwerden trotz einer konsequenten Behandlung der Erstinfektion. Die Therapie variiert je nach klinischem Bild der jeweiligen Infektion. Zudem wird in der Literatur eine Screeninguntersuchung der Patienten und ihrer engen Kontaktpersonen sowie eine bakterielle Dekolonisation der Betroffenen empfohlen. SCHLUSSFOLGERUNGEN Diese Arbeit fokussiert auf die Pathogenese und Risikofaktoren der rezidivierenden mukokutanen Infektionen durch PVL-positive S. aureus-Stämme und versucht einen diagnostischen und therapeutischen Algorithmus zur optimalen Patientenversorgung vorzuschlagen.Knowledge about the linear patterns of the skin is a key competence of dermatologists. Four major groups of linear patterns can be distinguished Langer lines, dermatomes, Blaschko lines and exogenous patterns. Langer lines run in the direction of the underlying collagen fibers (least skin tension) and play an important diagnostic role for some exanthematous skin diseases. In the thoracodorsal region, the distribution of the Langer lines gives rise to what is referred to as a 'Christmas tree pattern'. A dermatome is an area of skin that is supplied by a single spinal nerve. Disorders with a neuronal origin follow this pattern of distribution. The lines of Blaschko delineate the lines of migration of epidermal cells during embryogenesis. Exogenous linear patterns are caused by external factors. The present CME article will highlight important skin disorders that primarily present in the form of one of the aforementioned patterns. In addition, we will also address skin conditions that may secondarily follow with these patterns (or distinctly not do so) as the result of various mechanisms such as the Koebner phenomenon, reverse Koebner phenomenon, and Wolf's isotopic response. © 2020 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.in German HINTERGRUND Rezepturarzneimittel sind in Deutschland besonders im Bereich der topischen Therapie als wichtige Ergänzung zu zugelassenen Fertigarzneimitteln unverzichtbar. Bundesweit werden im ambulanten kassenärztlichen Bereich pro Quartal etwa 2 Mio. Rezepturen verordnet, 50 % davon durch Dermatologen. METHODIK Die Verordnungspraxis wurde evaluiert mittels eines Fragebogens, der an 186 niedergelassene Dermatologen sowie 1491 Apotheken in Rheinland-Pfalz und dem Saarland versendet wurde. Ziel war Erfassung und Einordnung von Verordnungsgewohnheiten und Problemen in der interdisziplinären Zusammenarbeit zur Optimierung der Patientenversorgung. ERGEBNISSE In 351 Fällen (23,5 %) wurde ein beantworteter Fragebogen von Apothekern und in 53 Fällen (28,4 %) von Dermatologen zurückgesendet. Als häufigster Beweggrund (83 %) für die Verordnung eines Rezepturarzneimittels wurde von Dermatologen die Verordnung großer Mengen angegeben, häufigste Krankheitsbilder für die Verwendung von Rezepturen waren die Schuppenflechte und Ekzeme. Die am häufigsten verordneten Wirkstoffe waren Triamcinolonacetonid (80 %), Erythromycin (78,3 %) sowie Clotrimazol (72,5 %). Apotheker gaben an, dass die Kommunikation mit Ärzten „mit Ärger verbunden“ (58 %) sei und in einem viel zu geringen Umfang stattfinde (34 %). SCHLUSSFOLGERUNGEN Rezepturarzneimittel sind wichtige Instrumente zur optimalen Patientenversorgung. Die interdisziplinäre Zusammenarbeit stellt Apotheker und Ärzte vor Probleme. Expertisen müssen besser vereint werden, beispielsweise durch intensivere Aus- und Fortbildung. Studien zum Rezepturen-Management sollten Probleme und Chancen in diesem Feld weiter untersuchen.BACKGROUND AND OBJECTIVES Anogenital warts (AGWs) are most commonly caused by low-risk human papillomavirus (HPV) types, and although they are the most frequent viral sexually transmitted infections (STIs), little is known about STI coinfections in affected patients. We therefore sought to assess STI coinfection rates in patients with AGW, specify STI coinfections and calculate the number needed to screen (NNS) for each STI. METHODS A retrospective cross-sectional study analyzing data sets from AGW patients treated in our clinic between 2008-2016. RESULTS 142/196 (72 %) patients had been variably screened for infections with HIV, HBV and HCV, Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium and HSV. The STI coinfection rate in all tested patients was 24.6 %, yielding an NNS of 4.1 to detect any STI. Of note, the coinfection rate did not differ significantly between heterosexual men, homosexual men and women, respectively. The NNS for syphilis was 8.4, for HIV 14.0, for HCV 28.5 and for HBV 39.0. The NNS for asymptomatic patients tested for HSV, Chlamydia trachomatis and Mycoplasma genitalium were 1.4, 5.3 and 12.0, respectively. CONCLUSION Due to the high prevalence of STI coinfections, AGW patients should be screened for other STIs. © 2020 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.we have read with interest the study performed by Fozouni et al. on the association between pre-transplant frailty and increased risk of early acute cellular rejection (ACR) after liver transplantation (LT). Chronic systemic inflammation, which is frequently detected in frail patients, was suspected by the Authors as the underlying pathogenic mechanism. This result was somehow unexpected since frail patients are usually clinically perceived as immunocompromised. Moreover, liver cirrhosis itself is associated with a severe immune dysfunction which is characterized by immunodeficiency and systemic inflammation. This article is protected by copyright. All rights reserved.The nuclear envelope (NE) is the central organizing unit of the eukaryotic cell serving as a genome protective barrier and mechanotransduction interface between the cytoplasm and the nucleus. read more The NE is mainly composed of a nuclear lamina and a double membrane connected at specific points where the nuclear pore complexes (NPCs) form. Physiological aging might be generically defined as a functional decline across lifespan observed from the cellular to organismal level. Therefore, during aging and premature aging, several cellular alterations occur, including nuclear-specific changes, particularly, altered nuclear transport, increased genomic instability induced by DNA damage, and telomere attrition. Here, we highlight and discuss proteins associated with nuclear transport dysfunction induced by aging, particularly nucleoporins, nuclear transport factors, and lamins. Moreover, changes in the structure of chromatin and consequent heterochromatin rearrangement upon aging are discussed. These alterations correlate with NE dysfunction, particularly lamins' alterations.
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