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Cancers immunotherapy by NC410, a new LAIR-2 Fc protein obstructing individual LAIR-collagen interaction.
After controlling for individual-level factors, geographic variation accounted for 4.00% and 13.67% of overall variance in short and long sleep duration, respectively; the corresponding estimates for difficulty initiating and maintaining sleep, daytime sleepiness, and finding sleep refreshing were 3.04%, 3.80%, and 5,08%, respectively. CONCLUSIONS There is a significant level of geographic variation in short and long sleep duration and sleep quality and this variation cannot be accounted for by differential distribution of individual characteristics across geographic areas. Future research is warranted to examine specific contextual factors that can account for this variation. OBJECTIVES We sought to examine the association of positive and negative experiences using social media (SM) and sleep disturbance in a national survey of U.S. young adults. METHODS Experiences using SM were assessed with 2 items asking participants about the percentage of time using SM that involved a negative/positive experience that they were personally involved in. Sleep disturbance was assessed using the validated PROMIS 4-item short form. Ordinal logistic regression was used to examine associations between positive and negative SM experiences and high sleep disturbance, while controlling for relevant covariates. RESULTS Although reporting high levels of negative experiences was significantly associated with greater odds of high sleep disturbance (AOR = 1.49, 95%CI = 1.18-1.89), reporting high levels of positive experiences was not associated with sleep disturbance. CONCLUSIONS These findings suggest that more robust examinations of negative SM experiences-especially as they relate to sleep disturbance-may be warranted. BACKGROUND The objective of this systematic review and meta-analysis was to investigate the associations between neighborhood socioeconomic status (nSES) and sleep duration in children aged 0-18 years. METHODS Three electronic databases were searched for relevant articles that assessed nSES and sleep duration (either subjectively or objectively). Inclusion criteria included peer-reviewed scholarly articles on the topic area that reported an association between nSES and sleep in children and adolescents. RESULTS The database searched identified 6080 potentially eligible studies, of which 1210 were selected for full-text review, and 8 met the inclusion criteria. Data included 67,677 unique participants. Studies were conducted in either the United States of America or Australia. Pooled estimates suggested that poorer nSES was associated with shorter child sleep duration (odds ratio 1.262; 95% confidence interval 1.086-1.467). This relationship between nSES and sleep was moderated by sleep assessment type (self-report versus actigraphy), child sex/gender, and child race/ethnicity. CONCLUSIONS Across studies, there is an association between nSES and child sleep duration. This study adds child sleep to the growing number of child health disparities associated with nSES. OBJECTIVES Sleep is essential for health and well-being and lack of sleep can have serious physiological consequences. This study aimed to evaluate sleep patterns and the influence of insomnia on quality of life. DESIGN The epidemiologic sleep study is a population-based study of sleep and risk factors for sleep disturbances. SETTING AND PARTICIPANTS This cross-sectional study recruited 574 men and 468 women aged 18 years or older randomly, to represent the population of Sao Paulo, according to gender, age, and socioeconomic status. MEASUREMENTS Data from polysomnography were used to assess sleep objectively and a validate questionnaire to assess quality of life. Validated questionnaires based on the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, assessed the perception of insomnia and categorized the sample as without insomnia symptoms, insomnia symptoms, and insomnia syndrome. Anthropometric data, objective sleep parameters and quality of life were assessed and the sample was distributed according to age for both genders. RESULTS Participants in both insomnia groups presented a worse perception of quality of life compared to without insomnia symptoms group in both genders. Women had a lower percentage of participants without insomnia symptoms (33.3%), and a higher percentage of insomnia symptoms (48.6%), and insomnia syndrome (18.1%) than men (42.1%, 47.2%, and 10.7%, respectively). CONCLUSIONS Women presented more insomnia complaints and had a lower perceived quality of life compared to men, especially at young ages. Men and women with insomnia symptoms or insomnia syndrome had a lower quality of life score. OBJECTIVE We investigated associations of sleep duration and social jetlag with cardiometabolic outcomes. PARTICIPANTS Boys and girls aged 8-16 years from the Hispanic Community Health Study/Study of Latino Youth. MEASUREMENTS Participants (n = 1,208) completed a clinical examination where anthropometric characteristics, health behaviors, and health history were measured. Sleep duration was calculated as the weighted average of self-reported weekday and weekend bedtimes and wake times and categorized into age-specific cutoffs for short vs. normal sleep. "Social jetlag" was defined as the absolute difference in the midpoint of the sleep period between weekdays and weekends, measured continuously and dichotomized (≥2 hours), with higher values indicating more displacement of sleep timing across the week. AZD-5462 solubility dmso Regression models tested the associations between sleep measures (separately) and cardiometabolic outcomes (e.g., healthy eating index [0-100], physical activity-minutes per week, obesity, diabetes, hypertension) after adjustment for covariates. RESULTS The average sleep duration was 9.5 hours (95% confidence interval 9.3, 9.6) and the mean social jetlag was 2.5 (2.4, 2.7) hours. Participants with social jetlag reported more physical activity (β = 34.8 [13.14], P less then .01), had a higher healthy eating index (β = 1.77 [0.87], P less then .05] and lower odds of being overweight [OR = 0.66, (95% confidence interval 0.44, 0.99)]. Short sleep duration was associated with less physical activity but did not relate to other cardiometabolic outcomes. CONCLUSIONS Social jetlag was associated with healthier behaviors and a lower odds of being overweight. Given these mixed findings, future research should further evaluate how to best characterize sleep timing differences in youth to identify health consequences.
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