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Strong Biomimetic Nacreous Aramid Nanofiber Blend Films using Ultrahigh Cold weather Conductivity simply by Adding Graphene Oxide and also Edge-Hydroxylated Boron Nitride Nanosheet.
The results of this study present peptides of low molecular weight, obtained from chia seeds, as a potential adjuvant option for cancer treatment.
Studies have shown persons living in recovery homes for drug and alcohol problems make significant, sustained improvements. However, there is limited information about factors associated with outcomes. This study examined how perceptions of social environment of one type of recovery home, sober living houses (SLHs), were associated with length of stay (LOS).

SLH residents and their house managers (N = 416) completed the recovery home environment scale (RHES) that assessed social model recovery characteristics and the community-oriented program evaluation scale (CPES) that evaluated perceptions of the program environment.

Scales completed by residents predicted LOS, but those completed by house managers did not. Larger discrepancies between the two groups were associated with shorter LOS. The RHES was shown to be a stronger predictor of LOS than the CPES.

Results highlight the importance of the social environment in SLHs, particularly those most closely aligned with social model recovery principles.
Results highlight the importance of the social environment in SLHs, particularly those most closely aligned with social model recovery principles.
Amyotrophic lateral sclerosis (ALS) is a degenerative neuromuscular disease with marked clinical heterogeneity. This heterogeneity can be partly captured by clinical measures, such as the forced vital capacity (FVC) and ALS Functional Rating Scale-Revised (ALSFRS-R). We aimed to further characterize the performance of these clinical measures, including their independence and additivity, in predicting mortality.

We leveraged the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT ALS) database, which includes data from 23 clinical trials (n =2050). The primary exposures were baseline FVC and ALSFRS-R. The primary outcome was 1-y mortality. We performed correlation analyses, survival analyses and assessed classification performance using receiver operator characteristic (ROC) curves.

FVC and ALSFRS-R were weakly correlated (r=0.31, p< .001). A 1-SD increase in FVC (hazard ratio [HR] 0.66; 95% confidence interval [CI] 0.59-0.74) and ALSFRS-R (HR 0.75; 95% CI 0.68-0.82) were associated with reduced risk of 1-y mortality. ROC analyses showed optimal predictive cutoffs at 80% for FVC (area under the curve [AUC] 0.69) and 38 for ALSFRS-R (AUC 0.67). After stratifying patients based on these cutoffs, we found a marked reduction (HR 0.25; 95% CI 0.19-0.33) in incident mortality for patients in the high FVC and high ALSFRS-R group relative to the low FVC and low ALSFRS-R group.

ALSFRS-R and FVC are comparable predictors of survival that are only weakly correlated. When considered together, they synergistically predict survival. As such, consideration of both measures should be a routine part of prognostication in care of patients with ALS.
ALSFRS-R and FVC are comparable predictors of survival that are only weakly correlated. When considered together, they synergistically predict survival. As such, consideration of both measures should be a routine part of prognostication in care of patients with ALS.
Identify the medication adherence determinants in older adults with multimorbidity and polypharmacy.

A cross-sectional study was conducted in a non-probabilistic sample of 245 adults ≥65 years recruited in a general medical ward of one teaching hospital. Data were collected during hospital stay using a face-to-face interview based on a set of validated questionnaires, such as the measure treatment adherence, the beliefs about medicines questionnaire-specific and the geriatric depression scale. Descriptive and multiple linear regression analysis were performed.

Participants' mean age was 78.32 (SD 6.95) years and 50.6% were women. Older adults lived with an average of 7.51 (SD 1.95) chronic conditions and had a mean of 7.95 (min. 4; max. buy Triapine 18) medications prescribed. The proportion of older adults adherent to medication was 43.7%. Depression (


β

 = -0.142; p = 0.031), beliefs about treatment necessity (


β

 = 0.306; p = 0.001) and concerns about the medication (


β

 = -0.204; p = 0.001) were found as independent determinants of adherence.

Self-reported medication non-adherence appears to be common in older adults with multimorbidity and polypharmacy. Depression, necessity and concerns should be considered when assessing medication non-adherence in practice. This study will also contribute to develop an intervention to manage adherence in older people, as part of a doctoral research project.
Self-reported medication non-adherence appears to be common in older adults with multimorbidity and polypharmacy. Depression, necessity and concerns should be considered when assessing medication non-adherence in practice. This study will also contribute to develop an intervention to manage adherence in older people, as part of a doctoral research project.
Epidemiologic evidence links ischemic stroke to age, yet the mechanisms that underlie the specific and independent effects of age on stroke remain elusive, impeding the development of targeted treatments. This study tested the hypothesis that age directly aggravates stroke outcomes and proposes inflamm-aging as a mediator and potential therapeutic target.

3months- (young) and 18-20months-old (old) mice underwent transient middle cerebral artery occlusion (tMCAO) for 30minutes followed by 48hours of reperfusion. Old animals received weekly treatment with the TNF-α neutralizing antibody adalimumab over 4weeks before tMCAO in a separate set of experiments. Plasma levels of TNF- α were assessed in patients with ischemic stroke and correlated with age and outcome.

Old mice displayed larger stroke size than young ones with increased neuromotor deficit. Immunohistochemical analysis revealed impairment of the blood-brain barrier in old mice, i.e. increased post-stroke degradation of endothelial tight junctions mechanism of age-related worsening of stroke outcomes and potential therapeutic target in this context. Thus, this work provides a basis for tailoring novel stroke therapies for the particularly vulnerable elderly population.
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