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Formative years Strain and Metabolic Plasticity of Cognitive abilities: Influence on Neurogenesis along with Angiogenesis.
OBJECTIVE To investigate the effects of early intensive rehabilitation management on the recovery of motor function and activities of daily living in patients with moderate traumatic brain injury. #link# METHODS Eighty-seven patients (age range, 18-65 years) with traumatic brain injury that met the enrollment criteria were randomly divided into 2 groups. Group 1 received early and high-intensity rehabilitation management (from 7 days after injury, 7 d/wk, 4 times/d, 1 h/session) for 4 weeks; group 2 received ordinary rehabilitation (from 14 days after injury, 5 d/wk, 2 times/d, 1 h/session) for 4 weeks. The Fugl-Meyer Assessment (FMA, motor function) and Barthel Index (BI) were used to assess the daily living functional state before treatment, 3 months after injury, and 6 months after injury. Ezatiostat (GCS) was used to assess outcomes 6 months after injury. RESULTS Three months after rehabilitation, the FMA (motor function) score was significantly higher in the early intensive intervention group versus the control group (59.83 ± 11.87 vs. 44.56 ± 8.32, respectively; P 0.05). Six months after rehabilitation, the FMA score and BI score were significantly higher in the early intensive intervention group versus the control group (FMA 73.18 ± 16.55 vs. 57.86 ± 10.67, P less then 0.01; BI 87.17 ± 13.85 vs. 60.68 ± 11.98, P less then 0.01, respectively). The GCS score was higher in the early intensive intervention group versus the control group (4.24 ± 0.91 vs. 3.43 ± 0.88, P less then 0.05, respectively) 6 months after injury. CONCLUSIONS Early intensive rehabilitation management might be more beneficial for neurologic function and activities of daily living in patients with moderate traumatic brain injury. BACKGROUND Symptomatic peritumoral edema (PTE) is a known complication after radiosurgical treatment of meningiomas. Although the edema in most patients can be successfully managed conservatively with corticosteroid therapy or bevacizumab, some medically refractory cases may require surgical resection of the underlying lesion when feasible. Laser interstitial thermotherapy (LITT) continues to gain traction as an effective therapeutic modality for the treatment of radiation necrosis where its biggest impact is through the control of peritumoral edema. CASE DESCRIPTION A 56-year-old woman with neurofibromatosis 2 presented with a symptomatic, regrowing left frontotemporal lesion that had previously been radiated, then resected with confirmed recurrence of grade I meningioma, and subsequently radiated again for lesion recurrence. Given her history of 2 prior same-side craniotomies, including a complication of wound infection, she was not a candidate for further open surgical resection. Having failed conservative management, she underwent LITT with intraoperative biopsy demonstrating viable grade I meningioma. Postoperatively, she demonstrated radiographic marked, serial reduction of PTE and experienced resolution of her symptoms. CONCLUSIONS This case demonstrates that LITT may be a viable alternative treatment for patients with meningioma with symptomatic PTE who have failed medical therapy and require surgical intervention. OBJECTIVE The HOSPITAL score (HS) and LACE index (LI) are 2 validated methods for quantifying the risk of 30-day unplanned readmission after discharge. However, neither score has been validated in the neurosurgical population. This study evaluated the HS and LI in the neurosurgical population as effective predictors for 30-day unplanned readmission. METHODS We performed a prospective, cohort analysis of all consecutive adult patients admitted to the neurosurgical service between October 1, 2018 and May 1, 2019. Patient medical records were used to calculate HS and LI. HS defined groups as low risk (0-4), intermediate (5-6), and high (7-12); LI defined risk as low (1-4), moderate (5-9), and high (10-19). Data analysis used univariate and multivariate logistic regressions. RESULTS The 1242 patients included 626 women (50.4%). The average age was 57.9 years, and most patients (86.5%) underwent surgery during their admission. In multivariate logistic regression, intermediate-risk HS was not predictive of 30-day readmission (odds ratio [OR], 1.04; 95% confidence interval [CI], 0.57-1.88; P = 0.53), whereas high-risk HS did predict readmission (OR, 2.87; 95% CI, 1.49-5.54; P = 0.002). Likewise, moderate-risk LI was not predictive of 30-day unplanned readmission or mortality (OR, 1.59; 95% CI, 0.88-2.85; P = 0.12); however, high-risk LI did predict unplanned readmission or mortality (OR, 2.58; 95% CI, 1.16-5.73; P = 0.02). Both HS and LI showed poor to moderate discrimination (C = 0.62 and 0.60, respectively). CONCLUSIONS A high-risk HS and high-risk LI were predictive of 30-day unplanned readmission. Although neither score is ideal for predicting moderate risk for 30-day unplanned readmission in neurosurgical patients, both have some predictiveness that may be clinically valuable. OBJECTIVE To assess the role of the difference between the proximal junctional angle (PJA) and rod contouring angle (RCA) (PJA-RCA) in the development of postoperative proximal junctional angle (PJK) in Lenke I and II adolescent idiopathic scoliosis (AIS) patients. METHODS We performed a retrospective analysis of 84 Lenke I and II AIS patients who underwent posterior segmental spinal instrumentation and fusion between 2012 and 2018 (minimum follow-up of 1.5 years and an average follow-up of 2 years) at a single institution. The full-spine x-ray films taken at the preoperative, postoperative, and final follow-ups were measured for each patient. The radiographic parameters were compared between the PJK and non-PJK groups, and binary logistic regression with forward elimination (conditional) was also performed to identify the risk factors for the occurrence of PJK. RESULTS Among the 84 patients (mean age 14.63 ± 1.33 years), the overall incidence of PJK was 23.81%. The PJK group showed a larger preoperative pelvnd postoperative PJA-RCA were the primary contributors to PJK in patients with AIS. CONCLUSIONS Large postoperative PJA-RCA and decreased TK are risk factors for PJK in Lenke I and II AIS patients, especially those with PJA-RCA greater than 5°, and the occurrence of PJK should be highly considered.
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