Notes

RANBP10 promotes glioblastoma progression simply by regulating the FBXW7/c-Myc path.
Test of sociality in poultry is mainly based on the bird's individual ability to make quick social discriminations. In recent years, a density-related permanence (DRP) test has been developed that enables us to classify young birds (while in groups) according to their individual permanence in proximity to either a high or low density of conspecifics (HD or LD, respectively). Thus, the result of the classification depends not only on the bird's individual response but also on the outcome of the social interactions within the whole group. The birds' performance in DRP was associated with underlying differences in social responses of their individuals. Quails in homogeneous groups of LD residents responded with less compact groups and higher levels of agonistic interactions to the presence of an intruder and showed higher levels of agonistic interactions among cage-mates than the homogeneous groups of HD birds. An acute stressor also induced a higher corticosterone response in the LD birds than in their HD counterparts. The present study addressed the question of whether contrasting DRP performance by Japanese quail can also reflect underlying differences in fearfulness and social reinstatement responses. Thus, LD and HD categorized juvenile birds underwent one of the following tests tonic immobility (TI), open-field (OF), or a one-way runway. Results showed that HD birds required more inductions and developed shorter responses (P ≤ 0.05) in the TI test and walked more, faster, and greater distances in the OF (P ≤ 0.05) than their LD counterparts. No differences between groups were found in short social reinstatement responses. The present findings suggest that underlying fearfulness is lower in the HD than in the LD birds. A reduced fearfulness could be regarded as an additional favorable trait of the HD-classified quail to cope with environmental challenging situations.Colonization of the gastrointestinal tract by potentially pathogenic bacteria and their shedding in animal feces is a fundamental factor for both animal health and human food safety. This study was conducted to evaluate the efficacy of salinomycin (Sal), direct-fed microbial (DFM), and Ferulago angulata hydroalcoholic extract (FAE) against Campylobacter jejuni in broiler chickens in a 6-week pilot-scale study. A total of six hundred and seventy two 1-day-old broiler chickens were equally divided into 6 groups (each consisting of 8 replicates of 14 birds) negative control (NC; untreated and uninfected); positive control (PC; untreated, infected with C. jejuni); PC + Sal; PC + DFM; PC + 200 mg/kg of FAE (FAE200); or PC + 400 mg/kg of FAE (FAE400). All these groups (except NC) were challenged with C. jejuni on day 15. The results showed that all experimental treatments improved (P less then 0.05) average daily gain compared with the PC group, and the best value was observed in the NC and FAE400 groups throughout the entire experimental period (day 1-42). The overall feed conversion ratio and mortality rate, as well as the population of C. jejuni (day 24 and 42) and Coliforms (day 42) in the ileum and cecum, were higher (P less then 0.05) in broiler chickens fed with the PC diet than for chickens in the other groups, except those in the FAE200 group. Immune responses revealed that among challenged birds, those that were fed diets DFM and FAE400 had significantly higher IgG (day 24 and 42), IgA (day 24), IL-6 (day 24), and gamma interferon (day 24 and 42) concentrations than the PC group. In conclusion, dietary FAE, especially at a high level of inclusion in broiler diet (400 mg/kg), could beneficially influence the immune status, as well as improve growth performance and intestinal microflora under Campylobacter challenge, which was comparable to those of Sal and DFM supplements.An experiment was conducted to evaluate effects of dietary phytase and inositol supplementation on phytate degradation in gizzard and ileal digesta contents of broilers from 1 to 43 d of age. One thousand nine hundred and twenty Yield Plus × Ross 708 male chicks were placed in 64 floor pens (30 birds/pen). Each pen received 1 of 8 dietary treatments from 1 to 43 d of age. Treatment 1 was formulated to contain 0.165 and 0.150% lower calcium and phosphorus, respectively, than treatment 7. Treatments 2 to 6 were formulated by adding phytase at 500, 1,500, 4,500, 13,500, and 40,500 phytase units (FTU)/kg, respectively, to treatment 1. Treatment 8 was established by adding inositol to treatment 7 based on the maximum inositol liberation in treatment 6. At 15, 29, and 43 d of age, gizzard contents, ileal digesta, and blood were collected for analysis of inositol and inositol phosphate (IP) 2, 3, 4, 5, and 6 concentrations. Increasing phytase from 0 to 40,500 FTU/kg resulted in log-quadratic reductions (P less then 0.01) of inositol pentaphosphate and inositol hexakisphosphate concentrations in the gizzard and ileal digesta contents of broilers at 15, 29, and 43 d of age. The increase in phytase doses in treatments 1 to 6 reduced IP3 and IP4 concentrations in a log-quadratic manner (P less then 0.05) at each collection period in gizzard contents but only at 43 d of age in the ileal digesta of broilers (P less then 0.01). BIBO 3304 price Log-quadratic increases (P less then 0.05) of inositol concentrations were observed in gizzard and ileal digesta contents when increasing phytase activity from 0 to 40,500 FTU/kg at each collection period, which translated to a log-quadratic increase (P less then 0.01) in plasma inositol concentration of broilers at 15, 29, and 43 d of age. Phytase supplementation up to 40,500 FTU/kg may benefit broilers by reducing phytate concentrations in the gizzard and ileal digesta contents. Moreover, inositol release in the ileal digesta may translate to increased plasma inositol concentration.To elucidate the role of anti-müllerian hormone (AMH) in regulating the development of ovarian follicles in laying hens, the expressions of follicle-stimulating hormone receptor (FSHR), AMH receptor type 2 (AMHR2), steroidogenic-related genes steroidogenic acute regulatory protein (STAR), cytochrome P450 side-chain cleavage (CYP11A1), and 3β-hydroxysteroid dehydrogenase (HSD3B1) genes were measured from different sized follicles and granulosa cells. The results showed that the expressions of FSHR and AMHR2 genes were higher in small follicles and decreased after follicular selection. Oppositely, the expressions of STAR, CYP11A1, and HSD3B1 were significantly increased after follicular selection. It indicated that AMHR2 might mediate AMH suppression in the stimulating effects of follicle-stimulating hormone (FSH) on steroidogenic-related genes expression. To make sure the effects of AMH in this process, a total of 40 hens were treated (negative control, sham operation, 150 ng AMH/d or 300 ng AMH/d) for 25 d. We analyzed ovarian morphology, progesterone concentration in blood plasma, and the expressions of steroidogenic genes in ovaries and follicles.
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