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Bunium persicum essential oil decreased acetic acid-induced rat colitis through reductions of NF-κB path.
Publishers 333 Seventh Avenue, New York, NY 10001, USA.BACKGROUND  Previous research has found that when the location of a talker was varied and an auditory prompt indicated the location of the talker, the addition of visual information produced a significant and large improvement in speech understanding for listeners with bilateral cochlear implants (CIs) but not with a unilateral CI. Presumably, the sound-source localization ability of the bilateral CI listeners allowed them to orient to the auditory prompt and benefit from visual information for the subsequent target sentence. A-1155463 mouse PURPOSE  The goal of this project was to assess the robustness of previous research by using a different test environment, a different CI, different test material, and a different response measure. RESEARCH DESIGN  Nine listeners fit with bilateral CIs were tested in a simulation of a crowded restaurant. Auditory-visual (AV) sentence material was presented from loudspeakers and video monitors at 0, +90, and -90 degrees. Each trial started with the presentation of an auditory alerting phr is significantly underestimated in standard, auditory-only, single-speaker, test environments. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.BACKGROUND  Sensory gating is a measure used to evaluate inhibitory deficits underlying neurological disorders. However, the effects of hearing loss (HL), thought to decrease inhibition, remain unknown on gating function. PURPOSE  The goal of this study was to investigate gating performance in HL. RESEARCH DESIGN  This was a prospective, cross-sectional study with independent group comparison and correlational design. STUDY SAMPLE  Eleven adults (mean age/standard deviation = 47.546 ± 7.967 years) with normal hearing (NH) and 11 adults (mean age/standard deviation = 56.273 ± 13.871 years) with mild-moderate high-frequency HL. DATA COLLECTION AND ANALYSIS  Cortical auditory evoked potentials (CAEPs) were recorded in response to tonal pairs via high-density electroencephalography. The CAEP response to the second tone in the pair (S2) was compared with the response to the first tone in the pair (S1) within groups. Amplitude gating indices were compared between groups and correlated with auditory behavioral measures. Current density reconstructions were performed to estimate cortical gating generators. RESULTS  Amplitude gating indices were decreased and correlated with elevated auditory thresholds. Gating generators in temporal, frontal, and prefrontal regions were localized in the NH group, while HL gating was localized in mainly temporal and parietal areas. CONCLUSIONS  Reduced inhibition may be associated with compensatory cortical gating networks in HL and should be considered when utilizing gating in clinical populations. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.BACKGROUND  Cerebral microangiopathy (CM) is a general term for small ischemic changes related to small blood vessels in the brain. Immune thrombocytopenia (ITP) is a rare acquired autoimmune disease that is characterized by low platelet count and increased risk of hemorrhage. We describe vestibular testing completed on a 64-year-old patient with CM and ITP presenting with complaints of general instability and listing while walking, decreased stability in dark environments, and blurred vision with head movement. Results indicated a severe loss of horizontal semicircular canal function bilaterally with a somatosensory-dependent pattern of postural instability. PURPOSE  This case emphasizes the importance of vestibular testing to determine the level of involvement of the vestibular system in the patient's symptomatology with known CM. Due to the increased risk of severe injury in those with ITP and the unknown effects this may have on the vestibular and balance systems, what is known about the pathophysiology oduced gain bilaterally. SHA results confirmed significant gain reductions at all frequencies tested and step velocity results indicated reduced gain and reduced time constants during all prerotary and postrotary measures. SOT results indicated a somatosensory-dependent pattern (i.e., reduced equilibrium index scores and falls in conditions 4, 5, and 6). CONCLUSIONS  These findings emphasize the importance of comprehensive vestibular evaluations of patients with CM, ITP, and complaints of instability. Identification and quantification of residual peripheral vestibular function as well as central system involvement can provide significant information pertinent to falls risk reduction and vestibular rehabilitation strategies, outcomes, and goals. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.in English, German Die SARS-CoV-2-Pandemie führte bei einer Mitte 60-jährigen Patientin zu vermehrten Symptomen einer bisher undiagnostizierten wahnhaften Störung und schließlich zu einem Suizidversuch. Aufgrund der Pandemie mit spür- und sichtbaren gesellschaftlichen Veränderungen können Menschen mit bislang subklinischen psychotischen Erkrankungen erstmals mit psychiatrischen Versorgungsangeboten in Kontakt kommen. Trotz fehlender Krankheitseinsicht und Ablehnung einer medikamentösen Therapie gelangen ein therapeutischer Beziehungsaufbau sowie eine tragfähige Vermittlung in ambulante Behandlungsangebote.in English, German ZIEL Bisher gibt es keine Studien zu den Erfahrungen und zum Belastungserleben bei Pandemien von ambulant tätigem medizinischem Personal. Es sollen die Auswirkungen der COVID-19-Pandemie im Frühjahr 2020 auf niedergelassene Neurologen und Psychiater untersucht werden. METHODE Es erfolgte eine E-Mail- und Fax-gestützte Befragung von 2072 niedergelassenen Psychiatern und Neurologen mit Fragen zur subjektiven Belastung, dem Erleben von realer Gefährdung und besonderen Bedingungen der Praxisorganisation. ERGEBNISSE Der Rücklauf betrug n = 396 (19 %). Mehr als 60 % der Ärzte fühlen sich stark bis sehr stark eingeschränkt. Mehr als ein Drittel machen sich große und sehr große Sorgen und sehen zudem eine hohe oder sehr hohe Gefahr einer eigenen Infektion. Für ein weiteres Drittel trifft das eher nicht zu. 91 % hatte in der letzten Arbeitswoche März keinen wissentlichen Kontakt zu COVID-19-positiv Getesteten. Ein Drittel fühlt sich persönlich finanziell bedroht und Umsatzverluste der Praxis werden erwartet.
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