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The purpose of the study was to determine if association exists between evidence-based provider training and clinician proficiency in electronic health record (EHR) use and if so, which EHR use metrics and vendor-defined indices exhibited association.

We studied ambulatory clinicians' EHR use data published in the Epic Systems Signal report to assess proficiency between training participants (n = 133) and nonparticipants (n = 14). Data were collected in May 2019 and November 2019 on nonsurgeon clinicians from 6 primary care, 7 urgent care, and 27 specialty care clinics. EHR use training occurred from August 5 to August 15, 2019, prior to EHR upgrade and organizational instance alignment. Analytics performed were descriptive statistics, paired t-tests, multivariate correlations, and hierarchal multiple regression.

For number of appointments per 30-day reporting period, trained clinicians sustained an average increase of 16 appointments (P < .05), whereas nontrained clinicians incurred a decrease of 8 appointments. Only the trained clinician group achieved postevent improvement in the vendor-defined Proficiency score with an effect size characterized as moderate to large (dCohen = 0.625).

Controversies exist on the return of investment from formal EHR training for clinician users. Previously published literature has mostly focused on qualitative data indicators of EHR training success. The findings of our EHR use training study identified EHR use metrics and vendor-defined indices with the capacity for translation into productivity and generated revenue measurements.

One EHR use metric and 1 vendor-defined index indicated improved proficiency among trained clinicians.
One EHR use metric and 1 vendor-defined index indicated improved proficiency among trained clinicians.Glioblastoma multiforme (GBM) are the most common and among the deadliest brain tumors in adults. Current mainstay treatments are insufficient to treat this tumor, and therefore, more effective therapies are desperately needed. Immunotherapy, which takes advantage of the body's natural defense mechanism, is an exciting emerging field in neuro-oncology. Adoptive cell therapy with chimeric antigen receptor (CAR) T cells provides a treatment strategy based on using patients' own selected and genetically engineered cells that target tumor-associated antigens. These cells are harvested from patients, modified to target specific proteins expressed by the tumor, and re-introduced into the patient with the goal of destroying tumor cells. NB 598 order Here, we review the history of CAR T-cell therapy, and describe the characteristics of various generations of CAR T therapies, and the challenges inherent to treatment of GBM. Finally, we describe recent and current CAR T clinical trials designed to combat GBM.
Antibiotic overuse results in adverse clinical outcomes. This study quantified the independent contributions of practice- and individual patient-level antibiotic prescribing to antibiotic treatment non-response in respiratory tract infections (RTIs) in primary care.

RTI episodes with antibiotic prescribed in 2018 were extracted from an Australian national general practice database. Practices were classified into tertiles by total antibiotic prescriptions per patient and ratios of broad- to narrow-spectrum antibiotic prescriptions. The association between practice- and individual patient-level antibiotic prescribing in the previous year and antibiotic treatment non-response (defined as prescription of a different antibiotic) ≤30 days after the initial RTI episode was quantified using generalized estimating equations.

Of 84 597 RTI episodes with antibiotics prescribed in 558 practices, 5570 (6.6%) episodes of treatment non-response were identified. Patients with high individual-level antibiotic prescribinresponse in patients with lower individual-level antibiotic use. The measure of practice-level antibiotic prescribing could potentially guide the improvement of antibiotic treatment.
Spine surgery is indicated for select patients with mechanical instability, pain, and/or malignant epidural spinal cord compression, with or without neurological compromise. Stereotactic body radiotherapy (SBRT) is an option for durable local control (LC) for metastatic spine disease.

To determine factors associated with LC and progression-free survival (PFS) for patients receiving postoperative stereotactic spine radiosurgery.

We analyzed consecutive patients from 2013 to 2019 treated with surgical intervention followed by SBRT. Surgical interventions included laminectomy and vertebrectomy. SBRT included patients treated with 1 to 5 fractions of radiosurgery. We analyzed LC, PFS, overall survival (OS), and toxicity. Univariate and multivariate analyses were performed.

A total of 63 patients were treated with a median follow-up of 12.5 mo. Approximately 75% of patients underwent vertebrectomy and 25% underwent laminectomy. One-year cumulative incidence of local failure was 19%. LC was significantly imry to radiosurgery. Preoperative embolization and higher radiotherapy dose were associated with improved LC warranting further study.
Early diagnosis of cognitive impairment may confer important advantages. Yet the prevalence of memory-related diagnoses among older adults with early symptoms of cognitive impairment is unknown.

A retrospective, longitudinal cohort design using 2000-2014 Health and Retirement Survey - Medicare Linked data. We leveraged within-individual variation to examine the relationship between incident cognitive impairment and receipt of diagnosis among 1,225 individuals aged 66 or older. Receipt of a memory-related diagnosis was determined by ICD-9-CM codes. Incident cognitive impairment was defined as the first assessment wherein the subject's modified Telephone Interview of Cognitive Status score was less than 12.

The unadjusted prevalence of memory-related diagnosis at cognitive impairment was 12.0%. Incident cognitive impairment was associated with a 7.3% (95% CI, 5.6% to 9.0%; p<0.001) higher adjusted probability of any memory-related diagnosis overall, yielding 9.8% adjusted prevalence of diagnosis. The increase in likelihood of diagnosis associated with cognitive decline was significantly higher among non-Hispanic Whites than non-Hispanic Blacks (8.
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