Notes

The dual-targeted prolyl aminopeptidase PAP1 is linked to proline piling up as a result of strain and during plant pollen development.
BACKGROUND Universities around the world, including Malaysia, have attracted many international students from different countries. Research has reported that acculturative stress resulting from international students' attempts to adjust to the cultures of host countries is one of the most challenging issues that affects their lives in general and academic lives in particular. OBJECTIVE This study aims to examine the effectiveness of an educational intervention on acculturative stress among new postgraduate international students joining Malaysian public universities. METHODS A cluster randomized controlled trial design with Malaysian public universities as the unit of randomization will be used in this study. Public universities will be randomized in a 11 ratio to be either in the intervention (educational program) or control group (waiting list). Participants in the intervention group will receive 7 sessions in 9 hours delivered by an expert in psychology and the researcher. The control group will receive thtion of acculturative stress and achieve a higher level of adjustment. Results will have implications for international students, policy makers at universities, the Malaysian Ministry of Higher Education, and future research. TRIAL REGISTRATION Clinical Trials Registry India CTRI/2018/01/011223; http//ctri.nic.in/Clinicaltrials/showallp.php?mid1= 21978&EncHid=&userName=Muhamad%20Hanafiah%20Juni. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) PRR1-10.2196/12950. ©Musheer Abdulwahid Al-Jaberi, Muhamad Hanafiah Juni, Hayati Kadir Shahar, Siti Irma Fadhilah Ismail, Murad Abdu Saeed, Lim Poh Ying. Originally published in JMIR Research Protocols (http//www.researchprotocols.org), 27.02.2020.BACKGROUND Promotion of physical activity, healthy eating, adequate sleep, and reduced sedentary behavior in adolescents is a major priority globally given the current increase in population health challenges of noncommunicable diseases and risk factors such as obesity. Adolescents are highly engaged with mobile technology, but the challenge is to engage them with mobile health (mHealth) technology. Recent innovations in mobile technology provide opportunities to promote a healthy lifestyle in adolescents. An increasingly utilized approach to facilitate increased engagement with mHealth technology is to involve potential users in the creation of the technology. OBJECTIVE This study aimed to describe the process of and findings from co-designing and prototyping components of the PEGASO Fit for Future (F4F) mHealth intervention for adolescents from different cultural backgrounds. METHODS A total of 74 adolescents aged 13 to 16 years from Spain, Italy, and the United Kingdom participated in the co-design of the io Ascolese, Sarah Atkinson, Kim Bul, Carme Carrion, Conxa Castell, Valentina Ciociola, Laura Condon, Mireia Espallargues, Janet Hanley, Nithiya Jesuthasan, Claudio L Lafortuna, Alexandra Lang, Federica Prinelli, Elisa Puidomenech Puig, Sarah A Tabozzi, Brian McKinstry. Originally published in JMIR mHealth and uHealth (http//mhealth.jmir.org), 02.03.2020.BACKGROUND HealthMindr is a mobile phone HIV prevention app for men who have sex with men (MSM). In a previous pilot study, HealthMindr was found to be acceptable among users and to demonstrate preliminary effectiveness for increasing pre-exposure prophylaxis (PrEP) uptake among MSM. PrEP is a highly effective HIV prevention intervention; however, uptake remains low. OBJECTIVE The aim of this study will be to assess the efficacy of a mobile app for increasing PrEP uptake among MSM in the southern United States. METHODS In this randomized controlled trial, we will assess the efficacy of HealthMindr for increasing PrEP uptake among MSM in the following three southern US cities Atlanta, Georgia; Jackson, Mississippi; and Washington, DC. In total, 657 men will be recruited and randomized to intervention and control arms in a 21 ratio. Participants in the intervention arm will receive access to the full HealthMindr app, with information and resources about PrEP (eg, frequently asked questions, risk assessment toola D Castel, Leandro A Mena, Samuel M Jenness, Aaron J Siegler, Patrick S Sullivan. Originally published in JMIR Research Protocols (http//www.researchprotocols.org), 21.02.2020.BACKGROUND Many rehabilitation clinics adopted serious games to support their physiotherapy sessions. Serious games can monitor and provide feedback on exercises and are expected to improve therapy and help professionals deal with more patients. However, there is little understanding of the impacts of serious games on the actual work of physiotherapists. selleck chemical OBJECTIVE This study aimed to understand the impact of an electromyography-based serious game on the practical work of physiotherapists. METHODS This study used observation sessions in an outpatient rehabilitation clinic that recently started using a serious game based on electromyography sensors. In total, 44 observation sessions were performed, involving 3 physiotherapists and 22 patients. Observation sessions were documented by audio recordings or fieldnotes and were analyzed for themes with thematic analysis. RESULTS The findings of this study showed that physiotherapists played an important role in enabling the serious game to work. Physiotherapists briefed patients, calibrated the system, prescribed exercises, and supported patients while they played the serious game, all of which amounted to relevant labor. CONCLUSIONS The results of this work challenge the idea that serious games reduce the work of physiotherapists and call for an overall analysis of the different impacts a serious game can have. Adopting a serious game that creates more work can be entirely acceptable, provided the clinical outcomes or other advantages enabled by the serious game are strong; however, those impacts will have to be assessed on a case-by-case basis. Moreover, this work motivates the technology development community to better investigate physiotherapists and their context, offering implications for technology design. ©João Almeida, Francisco Nunes. Originally published in JMIR Rehabilitation and Assistive Technology (http//rehab.jmir.org), 21.02.2020.
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