Notes

Adiponectin up-regulates the particular loss of myocardial autophagic flux brought on by simply β1 -adrenergic receptor autoantibody partially dependent upon AMPK.
Rechargeable lithium-ion batteries (LIBs) have dominated the energy market from electronic devices to electric vehicles, but pursuing greater energy density remains challenging due to the limited electrode capacity. Although increasing the cut-off voltage of LIBs (>4.4V vs. Li+/Li) can enhance the energy density, the aggravated electrolyte decomposition always leads to a severe capacity fading and/or expiry of battery. Herein, we present a new durable electrolyte for high voltage LIBs. The designed electrolyte is composed of mixed linear alkyl carbonate solvent with certain cyclic carbonate additives, in which the ethylene carbonate (EC) co-solvent was successfully avoided in use to suppress the electrolyte decomposition. As a result, an extremely high cycling stability, rate capability and high-temperature storage performance were demonstrated in the case of graphite | LiNi0.6Co0.2Mn0.2O2 (NCM622) battery at 4.45 V when such electrolyte was used. We confirm that the good compatibility of electrolyte with graphite anode and the mitigated structural degradation of NCM622 cathode are responsible for the high performance at the high potential above 4.4 V. This work presents the promising applications of high voltage electrolytes for pursuing high energy LIBs and provides a straightforward guideline to study the electrodes-electrolyte interface for higher stability. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Molecular computation, a rapidly developing multidisciplinary research field, has attracted increasing attention. A series of combinational logic circuits at molecular level have been constructed, however, the development of sequential logic circuits is still in its infancy due to the lack of ideal design tools. Taking advantage of unique assembly behaviors of a cyanine dye, we constructed a two-bit molecular counter circuit that can implement fundamental sequential logic functions, including number cumulating and descending. Further introducing a guanine-rich DNA strand as the cycle index, the counter can be reused several times and eventually be scaled-up to count up to 16 numbers. The supramolecular circuit shows high programmability, flexibility and reversibility, and it is prospected that the strategy would be applied in designing other advanced molecular circuits. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The medical education system is currently facing robust challenges as a consequence of the COVID-19 pandemic. CT7001 One of them is the maintenance of interactive learning techniques such as Team-Based Learning (TBL). TBL is an interactive teaching method that is learner-centered and instructor-directed. It sequentially involves self-work followed by teamwork. After providing the reading material, students are commonly asked to solve 10-20 multiple choice questions, known as the individual readiness assurance test (iRAT). Students are then assigned to answer the same questions while working together in teams, the team readiness assurance test (tRAT). This article is protected by copyright. All rights reserved.This should help the reader understand the issue in a manner that makes the extent of the problem clear and offers enough context to enable him/her to make a judgment about the applicability of the concerns to their own setting. This article is protected by copyright. All rights reserved.In our Bachelor of Nursing programme (part-time), students are registered nurses working within various clinical and primary care settings. In light of the COVID-19 pandemic, all face-to-face teaching has been suspended since early February and our epidemiology course has moved entirely to online teaching. We needed to address the following challenges The course is offered to final year students who are simultaneously working on front line. It was thought imperative, therefore, that students graduate on-time and that the the online learning activities be flexible. This article is protected by copyright. All rights reserved.BACKGROUND Evidence on acute respiratory failure (ARF) from antipsychotics is scant, and only one population-based study examined this drug safety issue in chronic obstructive pulmonary disease patients. Antipsychotics have been frequently prescribed off-label in adults, but whether antipsychotic use carries an increased ARF risk among adult patients is uncertain. METHODS We adopted a nested case-control study analyzing 716,493 adults aged ≥ 20 years, identified from the Taiwan nationwide healthcare claims records between January 2000 and December 2013. Among the study cohort, 7,084 adults with ARF and 12,785 disease risk scored-matched randomly-selected controls were analyzed. Multivariable logistic regression models were employed to estimate odds ratios (ORs) of ARF with antipsychotic usages. RESULTS Current, recent, and recent past use of antipsychotics was associated with a 2.33-fold (95% CI=2.06-2.64), 1.79-fold (95% CI=1.43-2.25) and 1.41-fold (95% CI=1.20-1.66) increased risk of ARF, respectively, compared with nonuse, while antipsychotics discontinued > 90 days carried no risk. A dose-dependent association was observed with current therapy of antipsychotics (test for trend, P 1 defined daily dose yielded the highest risk of 6.53-fold (95% CI=3.33-12.79). The findings were robust to using carbamazepine as an active-comparator. CONCLUSIONS Antipsychotic use was associated with an increased risk of ARF in adult patients. The risk was dose-dependent and markedly higher with current use of antipsychotic agents at doses of 1 DDD and above, less than 10% of this cohort. Physicians should be vigilant about any respiratory symptoms in patients currently receiving antipsychotics at such dose. This article is protected by copyright. All rights reserved.BACKGROUND In this study, the swelling behavior of roasted coffee particles in water and particularly its impact on particle diameter is examined by applying laser-diffraction analysis and microscopy. Several potential influencing factors are investigated initial particle size, roasting degree, and temperature. Additionally, the time dependency of swelling and particle shape is evaluated at two different temperatures. RESULTS We verify that particle erosion occurs-as observed by an increase of the fine particle fraction after wetting-and it is revealed that this effect is more pronounced with a rise in temperature. The total relative increase in particle size is determined as approximately 15% based on a broad range of different sized coffee grounds. It is demonstrated that the degree of swelling is independent of both the initial particle diameter and the roasting degree. The particle shape is found to be unaffected by swelling. This research reveals that swelling is initially quick, with 60-80% of the final steady-state diameter being reached after 30 seconds and completed after four minutes of wetting, i.
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