Notes

Keeping track of global warming and also child well being: The situation with regard to getting young children in all plans.
The ratios between AOA and AOB PARs (~0.87 ± 0.51) and gene abundances (~0.25 ± 0.24), however, were predominantly less then 1, indicating an AOB-dominated community. Comparing the different NH4+ consumption pathways, total aerobic oxidation accounted for 12-26% of the total consumption, with the largest proportion in the estuary, where the system was well oxygenated, and the lowest in the adjacent sea, where inorganic N was highly depleted. This study revealed the spatiotemporal patterns of AOA and AOB potential rates and gene abundance along gradients of human influences and identified organic matter and nutrients as key environmental factors that shaped the variation of AOA and AOB along the continuum.This study investigated the effects of applying different biochars to soil on shifts in the bacterial community, the biodegradation of antibiotics, and their relationships. In total, nine biochars were applied to agricultural soil contaminated with 16 antibiotics. Clustering analysis showed that the responses of bacteria at the genus level to biochars were highly dependent on the biochar feedstock rather than the pyrolysis temperature. Among the antibiotics tested in the study, the biodegradation percentage was lower for tetracyclines (TCs, 6-14%) than sulfonamides (SAs, 8-26%) and quinolones (QLs, 8-24%). For specific individual antibiotics from the same class with similar structures, the high adsorption affinity of soil particles for antibiotics due to hydrophobic interactions (logKow) and electrostatic interactions (pKa) resulted in low biodegradation percentages for antibiotics in the soil. The biodegradation of TCs was affected more by the biochar type (effect size -10% to 42%) than those of QLs (-26% to 14%) and SAs (-24% to 22%). According to the relationships determined between the bacterial taxonomic composition and biodegradation of antibiotics, Steroidobacter from the phylum Proteobacteria has significant positive correlations with the biodegradation of all SAs (p less then 0.01), thereby indicating that Steroidobacter had a high capacity for biodegrading SAs. Significant positive correlations were also detected (p less then 0.05) between specific genera (Iamia, Parviterribacter, and Gaiella) from the phylum Actinobacteria and the biodegradation of SAs. No significant positive correlations were found between bacterial genera and the biodegradation percentages for QLs and TCs, possibly due to the specific microorganisms involved in these biodegradation processes. The results in this study provide insights into the biodegradation mechanisms of antibiotics in soil and they may facilitate the development of strategies for the bioremediation of antibiotic-contaminated soil.Tebuthiuron (TBU) is a phenylurea herbicide that is extensively used in sugarcane fields. Owing to the low degradation rate, high water solubility, and leaching potential, TBU is believed to have harmful effects on aquatic organisms, such as anuran tadpoles. Contaminant effects can be influenced by temperature since increases in temperature are often associated with increased metabolic reactions. In this study, we evaluated the influence of temperature on the negative effects of TBU in bullfrog tadpoles (Lithobates catesbeianus) through a multi-biomarker approach. Tadpoles were exposed to 0 (control) 10, 50, and 200 ng L-1 of TBU for 16 days at 25 and 32 °C. Cryptotanshinone STAT inhibitor TBU increased the transcript levels of genes involved in biotransformation (glutathione S-transferase, GST, and sulfotransferase, SULT) and antioxidant (superoxide dismutase, SOD, and catalase, CAT) enzymes. TBU exposure also increased CAT and glutathione peroxidase (GPx) activities, whereas SOD and carboxylesterase activities were decreased. The highest temperature caused a decrease in the activities of ethoxyresorufin-O-deethylase and SOD but increased the activities of GST, GPx, glucose 6-phosphate dehydrogenase, and acetylcholinesterase. No effects of temperature or TBU exposure were observed in genotoxic markers (frequencies of micronucleous and nuclear abnormalities) or in lipid peroxidation levels. Tadpoles exposed to TBU at all tested concentrations presented a higher index of biomarker responses than that of the control groups. Higher values of severity scores from histological analyses were found in the liver of tadpoles exposed to 50 and 200 ng L-1 of TBU at 32 °C compared with those of the control group at the same temperature. These results indicate that TBU and temperature increases are able to disturb the metabolic homeostasis of L. catesbeianus tadpoles after 16 days of exposure, causing substantial alterations in biomarker responses and liver morphology.With increased interest in the toxic interactions of multiple toxins, biotoxicity models have to be urgently developed for joint toxicity evaluation. This study aimed to develop an optical biosensor based on living mammary cells for monitoring of cadmium (Cd)/deoxynivalenol (DON) in water and evaluating their combined toxicity. Our previous survey found that DON and Cd appeared simultaneously in various products, and RNA seq revealed that AP-1 participated in combined toxicity of DON+Cd in HT-29 cells. Thus AP-1 site-mCherry-based biosensors were constructed, optimized, and then tested for their applicability and stable fluorescence response activities. DON+Cd2+, DON, and Cd2+ induced dose-dependent fluorescence signal in the biosensors (at environmental exposure levels). The enhanced fluorescence signal suggested that the toxicity of DON+Cd2+ was enhanced compared with that of single toxin. The advantages of the biosensors include I) The easy and visual screening of multiple toxins on the basis of environmental exposure levels; II) Potential as a broad-spectrum tool for joint toxicity evaluation of DON+Cd; III) Pollution-free and stable fluorescence response; IV) A slight effect on viability.Many aquatic ecosystems in densely populated delta areas worldwide are under stress from overexploitation and pollution. Global population growth will lead to further increasing pressures in the coming decades, while climate change may amplify the consequences for chemical and ecological water quality. In this study, we explored the effects of climatic variability on eutrophication of groundwater, streams, rivers, lakes, estuaries, and marine waters in the Netherlands. We exploited the relatively dense monitoring information from the Dutch part of the Rhine-Meuse delta to evaluate the water quality response on climatic variability, in combination with anthropogenic pressures. Our results show that water quality of all water systems in the Netherlands is affected by climate variability in several ways 1) through the process of global climate change (mainly temperature and sea level rise), 2) through changes Atlantic ocean circulation patterns (more southwestern winds), 3) through changes in continental precipitation and river discharge fluctuations, and 4) through local climatic fluctuations.
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