Notes

Any multi-site, multi-disorder resting-state magnetic resonance picture database.
The newly emerged gas sensing detection of 3-hydroxy-2-butanone (3H-2B) biomarker is deemed as an effective avenue to indirectly monitor Listeria monocytogenes (LM). However, 3H-2B sensing materials requiring critically high sensitivity and selectivity, and ppb-level detection limit, remain challenging. Here, we report the advanced gas sensors built with bismuth vanadate microdecahedron (BiVO4 MDCD) 010 facets selectively decorated with Pd nanoparticles (Pd NPs, Pd-010BiVO4 MDCDs) for boosted detection of the 3H-2B biomarker. Meanwhile, BiVO4 MDCDs with overall facets are randomly deposited with Pd NPs (Pd-BiVO4 MDCDs). Comparatively, Pd-010BiVO4 MDCD sensors show 1 order of magnitude higher response toward the 3H-2B biomarker at 200 °C. Further, Pd-010BiVO4 MDCD sensors enable to detect as low as 0.2 ppm 3H-2B and show best selectivity and stability, and fastest response and recovery. selleck products Density functional theory calculations reveal a lower adsorption energy of 3H-2B onto Pd-010BiVO4 MDCDs than those of pristine and Pd-BiVO4 MDCDs. The extraordinary Pd-010BiVO4 sensing performance is ascribed to the Pd NP-assisted synergetic effect of the preferential adsorption of 3H-2B target molecules, accumulated sensing agent of ionic oxygen species, and concentrated catalysts on the 010 facets. This strategy offers rapid and noninvasive detection of LMs and is thus of great potential in the upcoming Internet of Things.The "turn-on" mode surface-enhanced Raman scattering (SERS) aptasensor for ultrasensitive ochratoxin A (OTA) detection was developed based on the SERS "hot spots" of AuNanostar@4-MBA@Au core-shell nanostructures (AuNS@4-MBA@Au) and exonuclease III (Exo III)-assisted target cycle amplification strategy. Compared with conventional gold nanoparticles, AuNS@4-MBA@Au provides a much higher SERS enhancement factor because AuNS exhibits a larger surface roughness and the lightning rod effect, as well as an excellent electromagnetic field between the AuNS core and the Au shell, which contribute to the superstrong SERS signal. Meanwhile, Exo III-assisted target cycle amplification can be used as an effective method for the further amplified detection of OTA. Additionally, the utilization of streptavidin magnesphere paramagnetic particles offers a green, economical, and facile technology for the accumulation and separation of the signal probe AuNS@4-MBA@Au from solution. All these factors lead to a significant enhancement of detectable signals and superhigh sensitivity. As a result, the limit of detection as low as 0.25 fg mL-1 could be achieved, which was lower than that in the other reported literatures on SERS methods for OTA detection as we know. The developed SERS aptasensor also provides a promising tool for foodstuff detection.The global sanitary crisis caused by the emergence of the respiratory virus SARS-CoV-2 and the COVID-19 outbreak has revealed the urgent need for rapid, accurate, and affordable diagnostic tests to broadly and massively monitor the population in order to properly manage and control the spread of the pandemic. Current diagnostic techniques essentially rely on polymerase chain reaction (PCR) tests, which provide the required sensitivity and specificity. However, its relatively long time-to-result, including sample transport to a specialized laboratory, delays massive detection. Rapid lateral flow tests (both antigen and serological tests) are a remarkable alternative for rapid point-of-care diagnostics, but they exhibit critical limitations as they do not always achieve the required sensitivity for reliable diagnostics and surveillance. Next-generation diagnostic tools capable of overcoming all the above limitations are in demand, and optical biosensors are an excellent option to surpass such critical issues. Label-free nanophotonic biosensors offer high sensitivity and operational robustness with an enormous potential for integration in compact autonomous devices to be delivered out-of-the-lab at the point-of-care (POC). Taking the current COVID-19 pandemic as a critical case scenario, we provide an overview of the diagnostic techniques for respiratory viruses and analyze how nanophotonic biosensors can contribute to improving such diagnostics. We review the ongoing published work using this biosensor technology for intact virus detection, nucleic acid detection or serological tests, and the key factors for bringing nanophotonic POC biosensors to accurate and effective COVID-19 diagnosis on the short term.This paper reports a simple and novel conformal doping strategy for microstructured silicon diodes using enriched 10B for sidewall doping while enabling enhanced neutron sensitivity. Monte-Carlo nuclear particle (MCNP) code simulations were initially used to calculate the neutron detection efficiency in the microstructured diodes as a function of geometry and pitch. A high-temperature anneal in 10B-filled diodes results in a conformal silicon p+ layer along the side walls of the trenches in the diodes. This results in large neutron detection areas and enhanced neutron detection efficiency when compared with planar detectors. With the method discussed here, a thermal neutron detection of ∼21% efficiency is achieved, which is significantly higher than the efficiency achieved in planar detectors (∼3.5%). The higher efficiency is enabled by the 10B acting as a source for conformal doping in the trenches, resulting in lower leakage current while also enabling neutron sensitivity in the microstructured diodes.To reduce environmental impact and sensor footprint, researchers need cost-effective and small-size surface tension and viscosity measurement devices. New measurement principles are needed for such sensors. We demonstrate that a sessile droplet's mechanical vibration can be transformed to audible sound, by recording the ultrasonic Doppler frequency shift in the form of an acoustic signal. The recorded sound wave reveals a droplet's surface tension and its viscosity, through its frequency spectrum and attenuation rate of the signal, respectively. Based on such sensors, two chemical measurements inside sessile droplets are shown (I) titration of a Ni2+ and Co2+ mixture with a surface-active indicator (using surface tension) and (II) measurement of the molecular weight of a polymer in solution (using viscosity). Unlike the commercial technique, our ultrasound-based sensor is cost-effective in terms of equipment price and sample volume.
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