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ister, ChiCTR1900028457. Copyright © 2020 Yang, Chen, Shao, Yan, Yue and Jiang.This study examines the effects of focused-attention meditation on functional brain states in novice meditators. There are a number of feature metrics for functional brain states, such as functional connectivity, graph theoretical metrics, and amplitude of low frequency fluctuation (ALFF). It is necessary to choose appropriate metrics and also to specify the region of interests (ROIs) from a number of brain regions. Here, we use a Tucker3 clustering method, which simultaneously selects the feature vectors (graph theoretical metrics and fractional ALFF) and the ROIs that can discriminate between resting and meditative states based on the characteristics of the given data. In this study, breath-counting meditation, one of the most popular forms of focused-attention meditation, was used and brain activities during resting and meditation states were measured by functional magnetic resonance imaging. The results indicated that the clustering coefficients of the eight brain regions, Frontal Inf Oper L, Occipital Inf R, ParaHippocampal R, Cerebellum 10 R, Cingulum Mid R, Cerebellum Crus1 L, Occipital Inf L, and Paracentral Lobule R increased through the meditation. Our study also provided the framework of data-driven brain functional analysis and confirmed its effectiveness on analyzing neural basis of focused-attention meditation. Copyright © 2020 Miyoshi, Tanioka, Yamamoto, Yadohisa, Hiroyasu and Hiwa.Since Tulving proposed a distinction in memory between semantic and episodic memory, considerable effort has been directed towards understanding their similar and unique features. Of particular interest has been the extent to which semantic and episodic memory have a shared dependence on the hippocampus. In contrast to the definitive evidence for the link between hippocampus and episodic memory, the role of the hippocampus in semantic memory has been a topic of considerable debate. This debate stems, in part, from highly variable reports of new semantic memory learning in amnesia ranging from profound impairment to full preservation, and various degrees of deficit and ability in between. More recently, a number of significant advances in experimental methods have occurred, alongside new provocative data on the role of the hippocampus in semantic memory, making this an ideal moment to revisit this debate, to re-evaluate data, methods, and theories, and to synthesize new findings. In line with these advances, tncepts, and meaning, as well as episodes and events, are instantiated and maintained in memory and will yield new insights into our two most quintessentially human abilities memory and language. Copyright © 2020 Duff, Covington, Hilverman and Cohen.Individuals on the autism spectrum are reported to show impairments in the processing of social information, including aspects of eye-movements towards faces. Abnormalities in basic-level visual processing are also reported. In the current study, we sought to determine if the latency of saccades made towards social targets (faces) in a natural scene as opposed to inanimate targets (cars) would be related to sub-clinical autism traits (ATs) in individuals drawn from a neurotypical population. The effect of stimulus inversion was also examined given that difficulties with processing inverted faces are thought to be a function of face expertise. No group differences in saccadic latency were established for face or car targets, regardless of image orientation. However, as expected, we found that individuals with higher autism-like traits did not demonstrate a saccadic face inversion effect, but those with lower autism-like traits did. Neither group showed a car inversion effect. Thus, these results suggest that neurotypical individuals with high autism-like traits also show anomalies in detecting and orienting to faces. In particular, the reduced saccadic face inversion effect established in these participants with high ATs suggests that speed of visual processing and orienting towards faces may be associated with the social difficulties found across the broader autism spectrum. Copyright © 2020 Laycock, Wood, Wright, Crewther and Goodale.Dynamic cognitive control adjustments are important for integrating thoughts and actions that take place during dynamic changes of environmental demands and support goal-directed behavior. selleckchem We investigated, in a working memory (WM) paradigm, whether dynamic adjustments in cognitive control based on previous trial load influence the neural response to neutral or unpleasant distracters. We also investigated whether individual self-reported abilities in controlling thoughts influence this effect. Participants performed a WM change detection task with low or high WM-related cognitive demands. An unpleasant or a neutral distractive image was presented at the beginning of each trial, prior to the WM task. We tested for control adjustments that were associated with the load level of the preceding trial task (N-1) on the neural response to the subsequent distractive image. We found an effect of the prior WM task load on a parieto-occipital waveform event-related potential (ERP) that appeared between 200 and 300 ms after the neutral distracter onset. This effect was not observed for the unpleasant distracter. Individual ability for controlling thoughts may influence the effect of cognitive control adjustments on distracter processing during the unpleasant condition. These findings provide evidence that (1) dynamic cognitive control adjustments are impaired by unpleasant distracters; and (2) the ability to control unpleasant thoughts is linked to individual differences in flexible cognitive control adjustments and shielding of WM representations from unpleasant distracters. Copyright © 2020 Pacheco, Figueira, Pereira, Oliveira and David.In light of growing concerns about opioid analgesics, developing new non-pharmacologic pain control techniques has become a high priority. Adjunctive virtual reality can help reduce acute pain during painful medical procedures. However, for some especially painful medical procedures such as burn wound cleaning, clinical researchers recommend that more distracting versions of virtual reality are needed, to further amplify the potency of virtual reality analgesia. The current study with healthy volunteers explores for the first time whether interacting with virtual objects in Virtual Reality (VR) via "hands free" eye-tracking technology integrated into the VR helmet makes VR more effective/powerful than non-interactive/passive VR (no eye-tracking) for reducing pain during brief thermal pain stimuli. Method Forty eight healthy volunteers participated in the main study. Using a within-subject design, each participant received one brief thermal pain stimulus during interactive eye tracked virtual reality, and each participant received another thermal pain stimulus during non-interactive VR (treatment order randomized).
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