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Natural and Synthetic Cannabinoids: Pharmacology, Employs, Unfavorable Medicine Occasions, and Substance Relationships.
05). Significant results were obtained in case of colistin against both the groups (p<0.001).

There was low antimicrobial resistance in community acquired carbapenem-resistant enterobacteraceae isolates.
There was low antimicrobial resistance in community acquired carbapenem-resistant enterobacteraceae isolates.
To determine the impact of Kisspeptin on male reproductive axis in a selected urban population.

The cross-sectional study was conducted at the Sindh Institute of Reproductive Medicine in collaboration with Aga Khan University, Karachi, from July, 2017, to February, 2018, and comprised infertile males with abnormal sperm parameters who were placed in Group A and fertile males with normal sperm parameters placed in Group B. Serum samples were estimated for Kisspeptin, follicle stimulating hormone, luteinizing hormone, testosterone and sex hormone-binding globulin using enzyme-linked immunosorbent assay. Data was analysed using SPSS 22.

Of the 313 male subjects, 178(57%) were in Group A and 135(43%) in Group B. Median Kisspeptin levels were higher among fertile males compared to infertile males (p<0.001). Mean follicle stimulating hormone, luteinizing hormone and testosterone values were higher among the fertile males (p<0.001). There was significant interaction between follicle stimulating hormone and testosterone (p<0.1).

Fertility in males depended on optimal secretion of Kisspeptin which exert edits effect on hypothalamic pituitary gonadal axis to increase male reproductive hormone production.
Fertility in males depended on optimal secretion of Kisspeptin which exert edits effect on hypothalamic pituitary gonadal axis to increase male reproductive hormone production.
To assess the predictive role of academic stress in anxiety, depression and somatisation among international students in Germany, and to explore if socio-demographic factors were of any significance in this regard.

The cross-sectional study was conducted from October 2017 to March 2018 in Germany and comprised students at universities offering programmes in the general subject category and had a strength of 1000 international students. selleck chemicals Data was collected using the Student Stress Inventory, Beck Anxiety Inventory, Major Depression Inventory, Pennebaker Inventory of Limbic Languidness and a socio-demographic questionnaire. Data was collected online, and was analysed using SPSS 21.

Of the 557 subjects, 261(46.9%) were males. The overall mean age of the sample was 25.77±3.79 years. Academic stress explained a great degree of variance in distress symptoms (p<0.05), while socio-demographic variables, except gender, were less important (p>0.05). Male students had a lower level of anxiety, depression, and somatisation (p<0.05). Age was inversely related to anxiety and somatisation (p<0.05).

There was a clear need to address the problems of higher level of psychological and somatic distress among international students.
There was a clear need to address the problems of higher level of psychological and somatic distress among international students.
We describe a novel surgical technique of slit-beam retro-illumination assisted phacoemulsification for cataract with coexisting corneal opacity.

We present two cases with cataract and coexisting opacity, who underwent slitbeam retro-illumination assisted phacoemulsification and further application of same process in 12 patients.

This technique is safe and provides excellent visualization during cataract surgery in patients with corneal opacities.
This technique is safe and provides excellent visualization during cataract surgery in patients with corneal opacities.
Vogt-Koyanagi-Harada (VKH) disease is defined as an autoimmune disorder characterized by bilateral granulomatous panuveitis with systemic manifestations, such as tinnitus, vertigo, and meningism caused by melanocyte antigen-reactive T-cells. Majority of VKH patients present at the age between 20 and 50 years. VKH is uncommon in elderly and challenging to manage. VKH is one of the important differential diagnosis of bilateral pan uveitis Case A 65 year/ female brought with chief complaint of sudden loss of vision in both eyes, headache and hearing problem for 1 month. She didn't give any history of other systemic illness, ocular surgery, ocular trauma, chronic use of medicament. Her visual acuity was hand movement with accurate projection of rays (HM) in both eyes The intraocular pressure (IOP) was 12mmHg in both eye. Slit-lamp bio microscopy revealed features of Pan uveitis in both eye. Systemic work up revealed no any other abnormalities. A diagnosis of early phase VKH was made and treated with intravenous pulse steroid therapy followed by tapering dose of oral steroid along with immunemodulator resulting in a very good visual recovery.

VKH can present in elderly. immunomodulator should be considered in elderly to prevent side effect of steroid along with recurrence of inflammation.
VKH can present in elderly. immunomodulator should be considered in elderly to prevent side effect of steroid along with recurrence of inflammation.
Pigment dispersion Syndrome (PDS) is a disorder with an onset in mid-twenties. There occurs a disruption of the iris pigment epithelium and deposition of pigment granules throughout the anterior segment. The incidence of PDS is 4-8/ 100,000. This condition is more commonly seen In Caucasians and is considered to be rare in Indians.

A 33-year-old male presented with the complaint of headache for three months. He had normal vision in both eyes with visual acuity of 6/6.

Krukenberg's spindle, a classic sign of pigment dispersion syndrome was evident on slit-lamp examination over the posterior corneal surface. Gonioscopy revealed a heavy and uniformly pigmented trabecular meshwork. OCT (Optical Coherence Tomography) demonstrated a characteristic iris configuration in the form of a mid-peripheral posterior bowing of the iris .Retinal nerve fibre layer analysis done on OCT revealed glaucomatous thinning in the right eye and a more advanced defect in the left eye. A visual field examination revealed the field to be outside normal limits in both the eyes pointing towards a diagnosis of pigment dispersion glaucoma.
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