Notes

The potency of immunosuppressive remedy in sufferers along with aplastic anaemia second to be able to chemoradiotherapy pertaining to cancers.
In this study, millimeter-sized chitosan/carboxymethyl cellulose (CTS/CMC) hollow capsules with molar ratio of 1/1 and 1/1.5 were successfully prepared by simple mixing and stirring of positively charged CTS and negatively charged CMC solutions under electrostatic interaction. The hollow capsule exhibited distinct removal performance for three typical dyes of methylene blue, methyl orange and acid blue-113 with different charged functional groups. The dye removal was mainly occurred on the hollow capsule membrane instead of the interior of hollow capsule. Typically, The CTS/CMC hollow capsule showed semi-permeability characteristics for methyl orange adsorption as the porous structure of the hollow capsule membrane. After the dye adsorption, the dyes also can release from the hollow capsules with different rates. The unique performance of CTS/CMC hollow capsule might have potential applications in the dye removal, the mixed dye wastewater separation and drug release.The major disadvantage of electrospun nanofibrous mats is their poor mechanical properties, which result from interfibrillar slips, porous structures, and the isotropic conformation of functional groups in fibers. In this work, we develop a tough electrospun mat without cost of both the stiffness and extensibility by combining two mutually exclusive polymers, i.e., generally "ductile" poly(vinyl alcohol) (PVA) and "stiff" α-chitin. The toughness of PVA/α-chitin is considerably higher (∼20 times) compared to PVA via intermolecular-fitted design and stoichiometric balance between hydrogen bonding donors and acceptors. Moreover, consistently oriented functional groups that are perpendicular to nanofibers improve mechanical properties. As a result, stiffness and extensibility are simultaneously increased by ∼19.3 and ∼3.8 times, respectively compared to PVA. The thermal stability with a 2.80-fold larger melting enthalpy of 823.95 ± 7.05 J g-1 than PVA. The great thermomechanical performance provides an insight for molecular design in electrospun nanofibers with chitin polymorphs.Natural cellulose is a kind of both traditional and emerging multifunctional material with high surface area, high strength, flexibility, and tunable surface chemistry, intensifying the quest for various products with properties that can mimic natural designs, functions, and properties in biomaterials, cosmetics, and food products. This review summarizes the modification methods of cellulose, preparation methods, physical and chemical properties and the possible applications of cellulose-based materials as pharmaceutical carriers. Herein, its main forms such as hydrogel, aerogel, and biomineral, and recent advances on sustainable cellulosic materials for pharmaceutical carrier applications were compared. The ongoing developments and challenges of cellulose-based materials in the biomedical field were discussed, and some possible suggestions were put forward.Native or hydrolyzed starch and yerba mate extract (10 wt.% or 20 wt.%) films prepared by extrusion and compression molding were investigated. Native starch material (TPNS) exhibited lower water vapor permeability and higher Young's Modulus (E) compared to hydrolyzed starch matrix (TPHS) but decreases in strain at break (εb) and toughness (T). The incorporation of 10 wt.% of extract in TPNS led to greater E and εb and it resulted the most hydrophobic material. Conversely, TPHS with 20 wt.% of additive resulted the film with the highest εb and T, indicating a plasticizing effect of the extract in this concentration and system. All materials disintegrated after 10 weeks of burial, contributing to waste reduction. Biofilms containing yerba mate extract showed antioxidant activity and color changes in different pH, indicating their promising role as active and smart packaging for food, in accordance with the new trends for biodegradable and functional packaging.Grafting beta-cyclodextrin (β-CD) onto cellulose nanocrystals (CNC) with the formation of well-dispersed nanoparticles (CNC-CD) and understanding their physicochemical properties are appealing but still challenging in controlled-release applications. Two immobilization methods were proposed and examined in this study; (i) copper (I) catalyzed click chemistry (CuACC) and (ii) carbodiimide coupling. Fourier-transform infrared spectroscopy (FTIR), UV-vis, elementary analysis, contact angle measurements, and thermogravimetric analysis (TGA) were conducted to elucidate the surface modifications. Phenolphthalein (PHTH) titration was used to quantify the grafting efficiency of β-CD on the CNC surface. The carbodiimide coupling in dimethyl sulfoxide was effective to introduce the highest amounts of β-CD (0.17 mmol/g sample) to the CNC in this study. The encapsulation process of bile surfactant, sodium cholate (NaC) was investigated by isothermal titration calorimeter (ITC), and the thermodynamic parameters were determined. The "molecular docking" brought by β-CD offers possible new applications of this sustainable nanohybrid system in the environmental, biomedical and pharmaceutical sectors.In this study, we tried to assess the substitute contents of HPMC used in commercial extended-release tablets directly by an innovative Raman imaging-based analysis technique and find their effects on the in vitro performance of these pharmaceuticals. Twenty-seven batches of metformin hydrochloride extended-release tablets from various sources were collected in the Chinese mainland market. read more While Raman imaging was used to qualitatively analyze the composition of the tablets, the MeO and HPO contents of HPMC were quantitatively assessed by a newly proposed calculation method based on the Raman intensity of corresponding characteristic band. Additionally, the dissolution test was performed to evaluate the relationship between HPMC substitution pattern and in vitro behavior. In sum, our findings indicate that the drug release rate can be downregulated by increasing the MeO content of HPMC, while the high HPO content would largely eliminate the variation of drug release profiles among batches.Gold nanoparticles (AuNPs) have been attracted considerable attention in cancer therapy, drug delivery and other applications due to their unique physical, chemical, and optical properties. Marine carbohydrates are important biological macromolecules that widely exist in marine algae and animals, such as alginate, carrageenan, porphyran, fucoidan, ulvan, agarose, and chitosan. Their excellent properties, such as biocompatibility, biodegradability and no irritation, make them widely used in biomedicine and nanomaterials fields. More importantly, they can be easily modified by functional groups, such as sulfation, acetylation, and carboxylation, to further extend their applications. The marine carbohydrates functionalized AuNPs can increase their biocompatibility and targeting in a green preparation method. Here, we review recent advances on marine carbohydrate-based AuNPs for cancer therapy, imaging, drug delivery and other biomedical fields. The topics of selective surface modification in different carbohydrates and further biomedical applications of AuNPs are also discussed.
Homepage: https://www.selleckchem.com/products/solcitinib.html