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The aim of this paper is to present the methodology and results of a study on the role played by an institution in higher education, the ESIC Business & Marketing School, in teaching different master's degree programmes to examine whether they respond to the demands of potential entrepreneurs who are seeking to acquire the tools and develop the skills necessary to eventually become successful. The main conclusions were that the students with the intention of achieving a higher level of entrepreneurial skills were enroled in the Executive Master of Business Administration (EMBA) programme without omitting other master's degree programmes also chosen by students with entrepreneurial concerns. It was also found that the variable with the highest impact on entrepreneurial motivation was family environment. Our data lead us to maintain that these students were not always going to start up a new business. The originality of this paper comes from our survey with 1,135 responses from the master's degree programmes taught in five cities in Spain with the inclusion of an analysis for LATAM students.COVID-19, the pandemic disease recently discovered in Wuhan (China), severely spread and affected both social and economic activity all over the world. Attempts to find an effective vaccine are challenging, time-consuming though interminable. Hence, re-proposing effective drugs is reliable and effective alternative. Taking into account the genome similarity of COVID-19 with SARS-CoV, drugs with safety profiles could be fast solution. Clinical trials encouraged the use of Chloroquine and Hydroxychloroquine for COVID-19 inhibition. One of the possible inhibition pathways is the competitive binding with the angiotension-converting enzyme-2 (ACE-2), in particular with the cellular Sialic acid (Neu5Ac). selleck products Here, we investigate the possible binding mechanism of ClQ and ClQOH with sialic acid both in the gas phase and in water using density functional theory (DFT). We investigated the binding of the neutral, monoprotonated and diprotonated ClQs and ClQOHs to sialic acid to simulate the pH effect on the cellular receptor binding. DFT results reveals that monoprotonated ClQ+ and ClQOH+, which account for more than 66% in the solution, possess high reactivity and binding towards sialic acid. The Neu5Ac-ClQ and the analogues Neu5Ac-ClQOH adducts were stabilized in water than in the gas phase. The molecular complexes stabilize by strong hydrogen bonding and π - π stacking forces. In addition, proton-transfer in Neu5Ac-ClQOH+ provides more stabilizing power and cellular recognition binding forces. These results shed light on possible recognition mechanism and help future breakthroughs for COVID-19 inhibitors.A systematic process for assessing progress toward landscape sustainability goals is developed and tested. Application of the approach builds capacity and promotes continual improvements in management practices, thus enabling timely action to address changing conditions while progressing toward locally defined goals. We consider how the approach applies to agricultural landscapes, that is farm ecosystem interactions with the environment and human well-being. We present lessons learned from applying the assessment approach in two contrasting situations large, high-input, commercial agriculture in northwestern Mexico and small, low-input family farms in the Western Highlands of Guatemala. Applying the approach reveals five attributes required for success and the means to achieve those conditions. (1) Having a capable local champion for the project is critical. (2) Implementation of the approach must be in concert with local people and organizations as well as with regional and national policies and programs. (3) Identification and engagement of key stakeholders is essential. (4) Application of the approach is not meant to be a one-time effort but rather an ongoing and systematic process. (5) Engagement and buy-in from stakeholders including multiple agency levels is essential for allocation of necessary resources and logistic support in the continuing implementation of the approach.Existing since 1964, the Committee for Mineral Processing is one of the most important units of the Austrian Mining Association. The Committee is engaged in publishing technical information concerning mineral processing, both in articles and in conferences. Since 2003 the Comittee has been performing the expert meeting for mineral processing at the Montanunversitaet of Leoben. This enables an intensive exchange of experience on different problems of mineral processing. Special efforts are made to integrate young technicians and students.Percutaneous transluminal angioplasty (PTA) is a very common interventional treatment for treating stenosis in arteriovenous fistula (AVF) used for hemodialysis vascular access. Restenosis occurs after PTA, resulting in vascular lumen loss and a decrease in blood flow. Experimental animal models have been developed to study the pathogenesis of stenosis, but there is no restenosis model after PTA of stenotic AVF in mice. Here, we describe the creation of a murine model of restenosis after angioplasty of a stenosis in an AVF. The murine restenosis model has several advantages, including the rapid development of restenotic lesions in the vessel after angioplasty and the potential to evaluate endovascular and perivascular therapeutics for treating restenosis. The protocol includes a detailed description of the partial nephrectomy procedure to induce chronic kidney disease, the AVF procedure for development of de novo stenosis and the angioplasty treatment associated with progression of restenosis. We monitored the angioplasty-treated vessel for vascular patency and hemodynamic changes for a period of 28 d using ultrasound. Vessels were collected at different time points and processed for histological analysis and immunostaining. This angioplasty model, which can be performed with basic microvascular surgery skills, could be used to identify potential endovascular and perivascular therapies to reduce restenosis after angioplasty procedures.An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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