Notes

ROS-responsive EPO nanoparticles improve ionizing radiation-induced hematopoietic damage.
Depending on the outflow depth and the occurrence of prolonged hot or cold atmospheric conditions, the onset of stratification could be likely shifted early or late. The 3D numerical simulation determined the individual effects of each operation, which strongly supported the results of the long term analysis. Since thermal stratification directly influences the reservoir's water quality regime, this study can be a helpful reference in optimizing the water quality management of the reservoir.Extreme weather events are occurring more frequently as a result of climate change. In October 2019, eastern Japan was hit by Hagibis, a large and high-speed typhoon. MK-8353 This unprecedented typhoon caused the evacuation of over 4000 people, injured more than 300 people, and damaged more than 98,000 dwellings throughout the affected area. Because floods are one of the most devastating natural disasters in Asia, providing an effective early warning system (EWS) is critical to reducing disaster impacts. However, warnings based only on natural hazard monitoring do not offer sufficient protection. Integrating natural hazard monitoring and social media data could improve warning systems to enhance the awareness of disaster managers and citizens about emergency events. We analyzed time-series data including rainfall intensity, 90-min-effective rainfall, and river water level as well as Twitter data related to disaster events during the 5-day period from 11 to 15 October, focusing on the most affected areas in Japan. The analysis included more than 60,000 tweets. Our analysis confirmed the utility of the statistical approach of outbreak detection with social media data in the early detection and local identification of multiple-flood events, and the results from the municipality-level analyses show that tweet frequencies related to the flood disaster ontological categories were significantly correlated to temporal variations in the hazard monitoring data. Thus, flood detection at the administrative level using social media data combined with current hazard monitoring data can enable a decision-driven EWS design. Interactive approaches for decision-making and knowledge production should continue to be considered in the face of climate-change-induced disasters.
Ossifying fibromyxoid tumor (OFMT) is an uncommon soft tissue neoplasm, with malignant potential and unclear histogenesis. OFMT exhibits a spectrum of histopathologic features including benign (typical), atypical and malignant subtypes. To the best of our knowledge, about 300 cases have been reported worldwide. We present the first reported case from Qatar.

A 36-year old Egyptian male, with no comorbidities was admitted electively as a day case for excision of left thigh suspected sebaceous cyst under local anesthesia. History, physical examination and soft tissue ultrasound imaging were unremarkable. Intraoperatively, the patient was found to have a hard-calcified mass adhering to the surrounding fascia which was excised en bloc. The histopathology result was of ossifying fibromyxoid tumor. The post-operative course along with 40 months follow-up were uneventful in terms of surgical complications and recurrence.

OFMT has marked features in terms of cytology. Though it is difficult to diagnose preoperatively, it should be considered in tumors involving soft tissue that demonstrate prominent ossification and calcification.

OFMT is a rare soft tissue neoplasm, and should be considered as a differential diagnosis in any subcutaneous swelling with a bony component. All OFMT patients should undergo a long course of follow-up to rule out and assess any recurrence or metastasis in the malignant variants.
OFMT is a rare soft tissue neoplasm, and should be considered as a differential diagnosis in any subcutaneous swelling with a bony component. All OFMT patients should undergo a long course of follow-up to rule out and assess any recurrence or metastasis in the malignant variants.
Chronic otitis media are still present and often overlooked. Our observation is interesting by the association of double purulent complications of chronic otitis media paravertebral abscess and lateral sinus thrombosis.

We report the case of a 54-year-old man with a long history of NPC, who presented to the hospital with severe right earache, associated with headache and 39°fever. CT scan and MRI assessed a complicated chronic otitis media of the middle ear by thrombophlebitis of the lateral sinus and posterior paravertebral abscess. He was put under antibiotic therapy and cortical mastoidectomy two weeks later. Nearly one-year follow up reveals a satisfactory recovery.

The chronic otitis media with effusion deserves careful monitoring. The early diagnosis and adequate treatment of this life-threatening lesion may result in excellent prognosis. Especially for young people in developing countries.
The chronic otitis media with effusion deserves careful monitoring. The early diagnosis and adequate treatment of this life-threatening lesion may result in excellent prognosis. Especially for young people in developing countries.Aberrant extracellular matrix (ECM) assembly surrounding implanted biomaterials is the hallmark of the foreign body response, in which implants become encapsulated in thick fibrous tissue that prevents their proper function. While macrophages are known regulators of fibroblast behavior, how their phenotype influences ECM assembly and the progression of the foreign body response is poorly understood. In this study, we used in vitro models with physiologically relevant macrophage phenotypes, as well as controlled release of macrophage-modulating cytokines from gelatin hydrogels implanted subcutaneously in vivo to investigate the role of macrophages in ECM assembly. Primary human macrophages were polarized to four distinct phenotypes, which have each been associated with fibrosis, including pro-inflammatory M1, pro-healing M2, and a hybrid M1/M2, generated by exposing macrophages to M1-and M2-promoting stimuli simultaneously. Additionally, macrophages were first polarized to M1 and then to M2 (M1→M2) to generate a phenotype typically observed during normal wound healing.
Website: https://www.selleckchem.com/products/mk-8353-sch900353.html