Notes

Molecular foundation fundamental resistance to Mps1/TTK inhibitors.
Our work underlines the importance, or we should rather say inevitability of postnatal ultrasound screening for congenital developmental anomalies in the kidneys.
Conclusions Available statistical data confirm that prenatal diagnostics of congenital developmental malformations of the urinary system in the Slovak Republic is not perfect. Our work underlines the importance, or we should rather say inevitability of postnatal ultrasound screening for congenital developmental anomalies in the kidneys.
The aim is to determine the clinical and morphological dependencies, which are important for diagnostics, treatment and prediction of outcomes of pathological processes in the region of the LTM with complicated eruption, as based on the study of histopathological changes of paradental tissue (mucous membrane, walls of retromolar pocket, alveolar bone tissue).

Materials and methods The materials of the study were 34 biopsy specimens of pathologically altered soft tissue and parodontium obtained as a result of pericoronectomy, extraction of the LTM and other surgical interferences performed based on the relevant indications in 28 patients in the region of the LTM with complicated eruption. Morphological and statistical research methods were used.

Results The local pathological processes, which chronologically precede the destructive changes in the hard tissue of a tooth (caries), are developed in patients of both genders with complicated LTM eruption in soft tissue of parodontium and the adjacent bone tisental tissue.

Conclusions The found pathological changes and the correlations justify surgical tactics on paradental soft and osseous tissues that are directed on the LTM sparing.
Conclusions The found pathological changes and the correlations justify surgical tactics on paradental soft and osseous tissues that are directed on the LTM sparing.
The aim is to get a thorough argument for the babesiosis pathogenetic scenario in the coordinate system «pathogen (Babesia spp.) - carrier (ticks of the Ixodoidea superfamily of the Ixodidea family) - reservoir (a susceptible organism)» with the emphasis on the epizootic/epidemic role of the carrier.

Materials and methods The macromicroscopic method of research was used in order to maximize the clarification of the babesiosis scenario, its pathogenetic links, the connection of the latter with attacks of active stages of ixodes ticks, types of circulation of ontogenetic forms of Babesia spp. in the body of carriers and their inoculation of the pathogen into an organism susceptible to it. The use of this method helped to strengthen the diagnostic potential of the study, and increase the reliability of the results obtained. Taking this into consideration it was focused on the epizootological/epidemiological aspects of babesiosis, the role and significance of the most vulnerable epizootic link - Ixodes ticks xodes ticks) is the central figure in the epidemic/epizootic coordinate system.
Conclusions In the pathogenetic scenario of babesiosis, the carrier (Ixodes ticks) is the central figure in the epidemic/epizootic coordinate system.
The aim To assess the quality of life in women after mastectomy.

Materials and methods The study included 25 women after mastectomy. The patients were aged 31 to over 50 years and were members of a breast cancer support group at the Holy Cross Cancer Centre in Kielce. During group meetings, the patients underwent rehabilitation and worked with psychologists and social workers.

Results Most women after mastectomy who underwent breast reconstruction or wore breast prostheses reported a better quality of life. Mastectomy affects ipsilateral upper limb function and causes difficulty with activities of daily living, such as cleaning, cooking, brushing hair, bathing, and dressing.

Conclusions 1. All women who rated their health as poor experienced such negative emotions as sadness, low mood, dejection. 2. Mastectomy affects ipsilateral upper limb function. 3. Cp2SO4 Breast reconstruction after mastectomy improves patient-rated quality of life. 4. Pain in the ipsilateral upper limb is considerably more common in women with a limited range of motion. 5. All women who participated in breast cancer support group meetings found support there and the time they spent together resulted in an improved quality of life.
Conclusions 1. All women who rated their health as poor experienced such negative emotions as sadness, low mood, dejection. 2. Mastectomy affects ipsilateral upper limb function. 3. Breast reconstruction after mastectomy improves patient-rated quality of life. 4. Pain in the ipsilateral upper limb is considerably more common in women with a limited range of motion. 5. All women who participated in breast cancer support group meetings found support there and the time they spent together resulted in an improved quality of life.
The aim of the research was to study the cellular composition of the gums in children of primary school age with normal body weight and overweight for further use of this data in the early diagnostics of periodontal diseases.

Materials and methods We examined 81 children aged from 6 to 12 years. Cytological examination of gingival cytograms was performed in all examined children.

Results Based on the analysis of the quantitative content of epithelial cells in children with normal body weight, their ratio was established, which is determined by the percentage of 0 6 94 (parabasal, intermediate, superficial). The obtained data completely coincide with the percentage of the differentiated ratio of epitheliocytes of multilayered squamous epithelium in children with normal body weight with inflammation and without it in the periodontal tissues. Our cytological examinations of gingival scrape smears in overweight children in contrast to the results of the study of epithelial scrape smears in children with normal body weight have some differences. Thus, in the process of calculation, the degree of differentiation of various epitheliocytes determines their percentage as follows - 3 7 90 (parabasal, intermediate, superficial) for children with gingivitis, and 2 5 93 (parabasal, intermediate, superficial) for children without inflammation in the periodontal tissues.

Conclusions The obtained results allowed us to conclude that in overweight children, in contrast to children with normal body weight, the number of parabasal cells decreases, and the number of superficial and intermediate cells increases.
Conclusions The obtained results allowed us to conclude that in overweight children, in contrast to children with normal body weight, the number of parabasal cells decreases, and the number of superficial and intermediate cells increases.
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