Notes

Self-assembling herbal antioxidants with regard to ischemia-reperfusion injuries.
In addition to the potential benefits of telemedicine, we must not forget the limitations of this method. However, it is important to emphasize that due to its wide availability, telemedicine services can provide sufficient flexibility for both primary and specialist care (outpatient and inpatient clinical care). For that very reason, it is an urgent need to define the national professional guidelines, legal and financing possibilities in this field in a long-term sustainable way.* Orv Hetil. 2020; 161(24) 983-992. *Disclaimer We closed the writing of this manuscript on the 30th of April, 2020. The COVID-19 pandemic and related research studies still have been changing dynamically since then.Due to the remarkable development in the field of hearing implantation, almost all kinds of hearing loss can be successfully rehabilitated. The first Hungarian Codacs™ (Cochlear's direct acoustic cochlear stimulator; Cochlear, Sydney, Australia) implantation was performed at the Department of Otorhinolaryngology and Head-Neck Surgery, Clinical Centre, University of Pécs. This electromechanical middle-ear implant can be offered for patients with bilateral, severe to profound, mixed-type hearing loss. In our case, a 67-year-old male patient with bilateral advanced otosclerosis was implanted, which led to significant improvement of the hearing threshold and speech reception. Orv Hetil. 2020; 161(24) 1015-1019.Introduction Heart failure is a high mortality cardiovascular disease affecting a huge patient population. Mortality rate data and their changes are important information regarding therapy effectiveness. Aim To study the death rate of heart failure and its change in comparison with the period before 2010. Method In the year 2017, data of heart failure patients were analysed number, overall and in-hospital mortality rate, 1-6-12-month death rates. Patients reported with codes of I50 and I42 blocks of the ICD-10 (International Statistical Classification of Diseases and Related Health Problems, 10th revision) classification were collected, irrespective of whether the codes were used as principal or additional diagnoses. Only all-cause mortality data were assessed. Results The prevalence of patients treated with heart failure was 1.1%. In-hospital death rate was 3.9% of this patient population, while 1-6-12-month death rates were 5.2-12-17%. Conclusions The prevalence of heart failure was less in 2017 than the 1.6% value for the year 2009. This can be due to the fact that this study collected patients treated or visited only this one year, while the other study in 2009 assessed patients diagnosed also in the previous 5 years but not appearing at any medical visit in 2009. Mortality rate data have also shown a remarkable improvement in comparison with the year 2009, but they still remained above the values reported for Western Europe. This improvement can be explained with the better up-titration of medications offering longer survival and the better adherence of patients. Orv Hetil. 2020; 161(24) 1012-1014.Introduction and aim This study aimed to describe the modified Regnault "B" oncoplastic technique as a standard volume-displacement level II oncoplastic breast-conserving surgery and the related clinicopathological study. Method A retrospective, single-centre study was performed between April 2012 and October 2018 involving 215 breast-cancer patients. Patient characteristics and postoperative complications were recorded, and the quality of life was rated by questionnaires. Aesthetic outcomes were evaluated with BCCT.core software and a five-point Likert scale. Results The mean patient age was 53 years (range 29-81 years), with a median follow-up of 47 months (range 7-85 months). The average surgery time was 47 min (range 35-85 min) and the pathological average size of the tumours was 33 mm (range 18-58 mm). Due to positive surgical margins, 13 (6%) completion re-excisions and 3 (1.4%) mastectomies were performed. In total, 16 complications (7.4%) were recorded. The median Likert scale score was 4.2, and the median overall aesthetic outcome assessed by BCCT.core was 1.3 points. According to the quality of life questionnaire, average points of the results demonstrated a high level of patient satisfaction. Conclusion In medium- to large-breasted patients, the modified Regnault "B" technique is a safe and repeatable level II volume-displacement oncoplastic breast-conservation technique. This technique allows extended removal (20-50% of breast tissue) of T1-T3 tumours from the upper outer quadrant and the border of outer quadrants of the breast with improved aesthetic results. The advantage of this technique is that contralateral symmetrisation is not required, while disadvantage of this technique is the skin incision on the breast skin envelope that can make some difficulties when completion mastectomy is required with immediate reconstruction. Orv Hetil. 2020; 161(24) 1002-1011.Background Accurate identification of new diagnoses of human papillomavirus (HPV) associated cancers and precancers is an important step towards the development of strategies that optimize the use of HPV vaccines. The diagnosis of HPV cancers hinges on a histopathologic report, which is typically stored in the electronic medical records (EMR) as free-form, or unstructured narrative text. Previous efforts to perform surveillance for HPV cancers have relied on the manual review of pathology reports to extract diagnostic information, a process that is both labor- and resource-intensive. Natural Language Processing (NLP) can be used to automate the structuring and extraction of clinical data from unstructured narrative text in medical records and may provide a practical and effective method for identifying patients with HPV vaccine-preventable disease for surveillance and research. Objective The objective of this study was to develop and assess the accuracy of a NLP algorithm for identification of individuals witrecision). Results The NLP algorithm's performance was validated on 949 pathology reports (anal cytology = 105, anal histology = 95, cervical cytology = 449, and cervical histology = 404). NMU chemical purchase The NLP algorithm demonstrated accurate identification of abnormal cytology, histology, and positive HPV tests with accuracies greater than 0.91 in all specimens. Precision (also known as positive predictive value) was lowest for anal histology reports (0.87; 95%CI = 0.59-0.98) and highest for cervical cytology (0.98; 95%CI= 0.95-0.99). The NLP algorithm missed two out of the 15 abnormal anal histology reports, which led to the relatively low recall/sensitivity (0.68; 95%CI= 0.43-0.87). Conclusions This study outlines the development and validity testing of a freely available and easily implementable NLP algorithm that is able to automate the extraction and classification of clinical data from cervical and anal cytology and histology reports with high accuracy. Clinicaltrial N/A.
Website: https://www.selleckchem.com/products/n-nitroso-n-methylurea.html