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Mechanical as well as Thermodynamic Attributes associated with Non-Muscle Contractile Tissue: The Myofibroblast and also the Molecular Engine Non-Muscle Myosin Variety IIA.
The use of selective insecticides aids farmers in maintaining pest populations below the economic threshold level. The integrated use of biological and chemical control is only possible if the effects of insecticides on natural enemies are studied. Although the IOBC/WPRS standards allow us to compare these studies worldwide, the methods used are sometimes inconsistent. This study determined the effects of ready-mix insecticides applied on pupae of Trichogramma pretiosum (Riley, 1879) (Hymenoptera Trichogrammatidae) and compared the effects on emergence of two different methods of exposing T. pretiosum pupae to insecticides immersed or sprayed using a Potter tower. Both methods gave the same results, indicating that they can be compared. Moreover, it is important to go beyond IOBC/WPRS classification and study the effects of pesticides on different biological parameters of natural enemies. This additional step may increase the likelihood of successful integration of biological and chemical control. Based on the emergence reduction, Chlorantraniliprole + lambda-cyhalothrin, abamectin + chlorantraniliprole, and alpha-cypermethrin + teflubenzuron were classified as innocuous (class 1). Cypermethrin + profenofos and cyproconazole + thiamethoxam were classified as slightly harmful (class 2). Methanol + methomyl and lufenuron + profenofos were classified as harmful (class 4). Abamectin + chlorantraniliprole, although classified as innocuous, reduced the parasitism, longevity, and flight capability of the adult parasitoids. None of these insecticides altered the emergence and sex ratio of the second generation. © The Author(s) 2020. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail [email protected] Mediterranean fruit fly, Ceratitis capitata (Weidemann), is one of the most economically important tephritid species worldwide. It has spread across six geographic regions as a result of successful invasions and continues to cause substantial losses to agricultural communities. Our study examined 1,864 flies originating from 150 localities, using mitochondrial DNA sequencing methods. We tested for population structure and revealed the genetic diversity for 1,592 specimens gathered from 144 wild fly collections from 46 countries representing the entire geographic range for this species. We also include in this study 272 Sterile Insect Technique (SIT) specimens from four SIT facilities. We recovered 202 haplotypes from the current sampling and updated previously published work to reveal a total of 231 haplotypes for this pest. These data show population structure at and below the regional level for these collections, shedding light on the current demographics for this species. We observed four common haplotypes, seen among 62% of the samples sequenced that have worldwide distribution. Three haplotypes were seen in SIT flies, with one seen as the predominant haplotype. Our work showed that two of the haplotypes were private to SIT flies, not present among wild fly collections. However, a third haplotype common among wild fly collections was also seen in one SIT facility but at a low frequency based on the current sampling. We provide guidance on the interpretation of these methods for the source estimation of current and future infestations. © Published by Oxford University Press on behalf of Entomological Society of America 2020.STUDY OBJECTIVES The study objectives were to examined accidental risks associated with insomnia or hypnotic medications, and how these risk factors interact with sex and age. METHODS A population-based sample of 3413 adults (Mage = 49.0 years old; 61.5% female), with or without insomnia, were surveyed annually for five consecutive years about their sleep patterns, sleep medication usage, and road collisions. RESULTS There was a significant risk of reporting road collisions associated with insomnia (HR =1.20; 95% CI = 1.00-1.45) and daytime fatigue (HR =1.21; 95% CI = 1.01-1.47). Insomnia or its daytime consequences were perceived to have played some contributory role in 40% of the reported collisions. Both chronic (HR = 1.50; 95% CI = 1.17-1.91) and regular use of sleep medications (HR = 1.58; 95% CI = 1.16 - 2.14) were associated with higher accidental risks, as well as being young female with insomnia and reporting excessive daytime sleepiness. CONCLUSIONS Both insomnia and use of sleep medications are associated with significant risks of road collisions, possibly because of or in association with some of their residual daytime consequences (i.e., fatigue, poor concentration). The findings also highlight a new group of at risk patients, i.e. young women reporting insomnia and excessive daytime sleepiness. © Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail [email protected] DNA cis-regulatory modules (CRMs) that control the expression of specific genes is crucial for deciphering the logic of transcriptional control. Natural genetic variation can point to the possible gene regulatory function of specific sequences through their allelic associations with gene expression. However, comprehensive identification of causal regulatory sequences in brute-force association testing without incorporating prior knowledge is challenging due to limited statistical power and effects of linkage disequilibrium. Sequence variants affecting transcription factor (TF) binding at CRMs have a strong potential to influence gene regulatory function, which provides a motivation for prioritizing such variants in association testing. Here, we generate an atlas of CRMs showing predicted allelic variation in TF binding affinity in human lymphoblastoid cell lines and test their association with the expression of their putative target genes inferred from Promoter Capture Hi-C and immediate linear proximity. We reveal >1300 CRM TF-binding variants associated with target gene expression, the majority of them undetected with standard association testing. selleck chemicals llc A large proportion of CRMs showing associations with the expression of genes they contact in 3D localize to the promoter regions of other genes, supporting the notion of 'epromoters' dual-action CRMs with promoter and distal enhancer activity. © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.
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