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This review details the currently known mutagenic consequences of cells surviving different cell death signaling pathways, with implications for potential oncogenic transformation. Understanding the mechanisms of mutagenesis associated (or not) with various cell death pathways will guide us in the development of future therapeutics to minimize therapy-related side effects associated with DNA damage.Water pollution caused by excessive nutrient and biological invasion is increasingly widespread in China, which can lead to problems with drinking water as well as serious damage to the ecosystem if not be properly treated. Aquatic plant restoration (phytoremediation) has become a promising and increasingly popular solution. In this study, eight native species of low-temperature-tolerant aquatic macrophytes were chosen to construct three combinations of aquatic macrophytes to study their purification efficiency on eutrophic water in large open tanks during autumn in Guangzhou City. The total nitrogen (TN) removal rates of group A (Vallisneria natans + Ludwigia adscendens + Monochoria vaginalis + Saururus chinensis), group B (V. natans + Ipomoea aquatica + Acorus calamus + Typha orientalis), and group C (V. natans + L. adscendens + Schoenoplectus juncoides + T. orientalis) were 79.10%, 46.39%, and 67.46%, respectively. The total phosphorus (TP) removal rates were 89.39%, 88.37%, and 91.96% in groups A, B, and C, respectively, while the chemical oxygen demand (COD) removal rates were 93.91%, 96.48%, and 92.78%, respectively. In the control group (CK), the removal rates of TN, TP, and COD were 70.42%, 86.59%, and 87.94%, respectively. The overall removal rates of TN, TP, and COD in the plant groups were only slightly higher than that in CK group, which did not show a significant advantage. This may be related to the leaf decay of some aquatic plants during the experiment, whereby the decay of V. natans was the most obvious. The results suggest that a proper amount of plant residue will not lead to a significant deterioration of water quality.This cross-sectional study utilizes data from a nationwide web-based survey aimed to identify the factors affecting the emotional well-being of Brazilian adolescents aged 12-17 during the period of school closures and confinement. Data collection took place from 27 June to 17 September 2020. We used the "virtual snowball" sampling method, and students from private and public schools were included. A total of 9470 adolescents were analyzed. A hierarchical logistic regression model was used to find the factors associated with reporting at least two of three self-reported problems-sadness, irritability, and sleep problems. The main proximal factor was loneliness (AdjOR = 8.12 p less then 0.001). Problems related to school closures also played an important role. Regular intake of fruits and vegetables, as well as physical activity, demonstrated a positive influence on emotional well-being, while excessive screen time (AdjOR = 2.05, p less then 0.001) and alcohol consumption negatively affected outcomes (AdjOR = 1.73, p less then 0.001). As for distal variables, less affluent adolescents were the most affected, and males reported fewer emotional problems than females. Uncertainty regarding the disease in a context of socioeconomic vulnerability, together with rises in unhealthy behaviors and isolation from their immediate social circles, have negatively affected adolescents' emotional status throughout the COVID-19 pandemic.Adhesion to intestinal mucus is the first step for microbiota colonization in early life. Polyamines are polycations with important physiological functions in both procaryotic and eucaryotic cells. However, their role in intestinal mucus adhesion is not known. The objective of the present study was to evaluate whether exogenous polyamines (putrescine, spermidine, spermine, and their combination) would alter the adhesive properties of Lacticaseibacillus rhamnosus GG (LGG), Bifidobacterium animalis subs. read more lactis Bb12, Cronobacter sakazakii, and Escherichia coli. Human intestinal mucus was isolated from healthy infants (0-6-month-old and 6-12-month-old) and healthy adults (25-52 years old). Spermidine significantly increased Bb12 adhesion (p less then 0.05) in the mucus of infants (0-6 months) but reduced the adhesion of LGG in adult mucus (p less then 0.05) with no significant effect in any of the infant groups. Spermine was more effective than polyamine combinations in reducing C. sakazakii (p less then 0.05) adhesion in early infant mucus (0-6 months). The adhesion ability of E. coli remained unaffected by exogenous polyamines at any age in the concentrations tested. Our data suggest that polyamines may modulate the bacterial adhesion to mucus depending on the bacterial strain and depending at what age the mucus has been generated.Public-private partnerships (PPP) represent an alternative model of health management focused on improving the quality of health services, particularly in emerging countries. To date, a systematic method to improve the perceived quality of health services by healthcare users in Peru has not been established. The purpose of this study was to evaluate the quality of health services in two PPP hospitals in Peru using the Kano model. A prospective cross-sectional descriptive observational study was carried out through a health service satisfaction survey using the Kano model methodology, measuring six categories of attributes. A total of 250 users of the health services were surveyed in the two PPP hospitals, located in Lima and Callao, using non-probability convenience sampling. Of the 31 attributes evaluated by the patients, 27 (81%) were classified as having a one-dimensional-type attribute, 3 (10%) were reported as mandatory, and 1 (3%) was considered as inverse. These results suggest that the presence of most of the attributes evaluated was relevant to maintaining the level of user satisfaction and that the absence of these attributes generated dissatisfaction in the users. The results showed that the users' evaluation of health services was multidimensional-namely, their evaluation was focused not only on the interaction space between the patient and medical personnel but also addressed other interaction services.
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